ENSG00000116830

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369466 ENSG00000116830 HEK293_OSMI2_2hA HEK293_TMG_2hB TTF2 protein_coding protein_coding 30.99517 15.40719 42.49646 0.6276934 0.5555108 1.463143 4.839968 3.3637084 5.757322 0.004611071 0.1465073 0.77356618 0.1778458 0.2190000 0.13563333 -0.083366667 3.530418e-04 4.578341e-07 FALSE TRUE
ENST00000427271 ENSG00000116830 HEK293_OSMI2_2hA HEK293_TMG_2hB TTF2 protein_coding protein_coding 30.99517 15.40719 42.49646 0.6276934 0.5555108 1.463143 2.997631 2.9553450 2.998466 0.567926442 0.2451154 0.02082806 0.1130375 0.1898000 0.07073333 -0.119066667 4.768771e-04 4.578341e-07 FALSE TRUE
ENST00000480701 ENSG00000116830 HEK293_OSMI2_2hA HEK293_TMG_2hB TTF2 protein_coding processed_transcript 30.99517 15.40719 42.49646 0.6276934 0.5555108 1.463143 3.651139 1.6098722 4.329459 0.017302739 0.1030484 1.42163521 0.1248125 0.1047333 0.10186667 -0.002866667 9.681231e-01 4.578341e-07   FALSE
MSTRG.1904.12 ENSG00000116830 HEK293_OSMI2_2hA HEK293_TMG_2hB TTF2 protein_coding   30.99517 15.40719 42.49646 0.6276934 0.5555108 1.463143 5.927591 3.4050875 7.780721 0.557219283 0.4197419 1.18983422 0.2008000 0.2230333 0.18320000 -0.039833333 7.314383e-01 4.578341e-07 FALSE TRUE
MSTRG.1904.13 ENSG00000116830 HEK293_OSMI2_2hA HEK293_TMG_2hB TTF2 protein_coding   30.99517 15.40719 42.49646 0.6276934 0.5555108 1.463143 1.879109 0.4499678 2.500319 0.110412601 0.4586308 2.44826615 0.0525875 0.0292000 0.05913333 0.029933333 2.023518e-01 4.578341e-07 FALSE TRUE
MSTRG.1904.6 ENSG00000116830 HEK293_OSMI2_2hA HEK293_TMG_2hB TTF2 protein_coding   30.99517 15.40719 42.49646 0.6276934 0.5555108 1.463143 10.212725 1.7848292 17.394619 0.406548228 0.9869004 3.27755178 0.2759292 0.1141667 0.40890000 0.294733333 4.578341e-07 4.578341e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116830 E001 0.8513531 0.0178151312 6.081423e-01 7.279839e-01 1 117060101 117060311 211 + 0.209 0.307 0.728
ENSG00000116830 E002 0.3666179 0.0321415917 5.140924e-01 6.488386e-01 1 117060312 117060313 2 + 0.082 0.180 1.315
ENSG00000116830 E003 0.8083770 0.0640953122 1.747746e-01 2.944153e-01 1 117060314 117060314 1 + 0.150 0.404 1.893
ENSG00000116830 E004 2.0003262 0.0144572936 9.089204e-01 9.461372e-01 1 117060315 117060325 11 + 0.456 0.484 0.139
ENSG00000116830 E005 2.0003262 0.0144572936 9.089204e-01 9.461372e-01 1 117060326 117060328 3 + 0.456 0.484 0.139
ENSG00000116830 E006 42.4726652 0.0121156069 8.217956e-03 2.433593e-02 1 117060329 117060361 33 + 1.669 1.459 -0.715
ENSG00000116830 E007 49.6047145 0.0052346710 9.597208e-05 5.031583e-04 1 117060362 117060374 13 + 1.746 1.488 -0.878
ENSG00000116830 E008 84.3034217 0.0003219666 1.640947e-07 1.599549e-06 1 117060455 117060557 103 + 1.966 1.743 -0.752
ENSG00000116830 E009 0.7300267 0.0459659187 6.474172e-02 1.346226e-01 1 117060558 117060561 4 + 0.082 0.406 2.903
ENSG00000116830 E010 90.0270693 0.0005597124 5.506727e-09 7.132729e-08 1 117062387 117062473 87 + 2.000 1.751 -0.838
ENSG00000116830 E011 78.7952101 0.0009595143 5.835916e-05 3.233496e-04 1 117073661 117073727 67 + 1.927 1.747 -0.605
ENSG00000116830 E012 277.1199999 0.0008862502 1.586828e-11 3.196042e-10 1 117074870 117075294 425 + 2.468 2.292 -0.590
ENSG00000116830 E013 364.3795151 0.0007272794 2.704176e-13 7.233804e-12 1 117075295 117075859 565 + 2.585 2.419 -0.552
ENSG00000116830 E014 153.2378682 0.0002465256 1.443361e-03 5.451039e-03 1 117076180 117076294 115 + 2.191 2.101 -0.303
ENSG00000116830 E015 0.9190056 0.0153012292 6.302741e-02 1.317527e-01 1 117076295 117076389 95 + 0.150 0.484 2.308
ENSG00000116830 E016 174.5284573 0.0002635727 2.660480e-02 6.516855e-02 1 117076641 117076823 183 + 2.236 2.181 -0.185
ENSG00000116830 E017 6.6353777 0.0261126532 8.594315e-01 9.133205e-01 1 117077895 117077915 21 + 0.869 0.853 -0.063
ENSG00000116830 E018 166.3173036 0.0044931139 1.800751e-03 6.601777e-03 1 117077916 117078043 128 + 2.235 2.106 -0.433
ENSG00000116830 E019 140.7198152 0.0002330822 5.419941e-06 3.827313e-05 1 117079568 117079649 82 + 2.168 2.026 -0.477
ENSG00000116830 E020 71.3761776 0.0007120008 7.367695e-04 3.031817e-03 1 117081828 117081830 3 + 1.878 1.727 -0.512
ENSG00000116830 E021 157.9267014 0.0002771118 1.073621e-05 7.084690e-05 1 117081831 117081947 117 + 2.214 2.084 -0.435
ENSG00000116830 E022 11.1260494 0.0016556983 9.494803e-01 9.723773e-01 1 117081948 117082031 84 + 1.054 1.071 0.060
ENSG00000116830 E023 178.0938133 0.0006737155 2.856287e-02 6.913793e-02 1 117084018 117084168 151 + 2.246 2.189 -0.191
ENSG00000116830 E024 154.8149445 0.0045448793 2.032160e-01 3.302509e-01 1 117086417 117086522 106 + 2.182 2.133 -0.164
ENSG00000116830 E025 170.8089948 0.0002442765 2.390495e-01 3.730044e-01 1 117088801 117088982 182 + 2.217 2.193 -0.082
ENSG00000116830 E026 160.4695003 0.0002771727 2.414755e-01 3.759105e-01 1 117090055 117090208 154 + 2.191 2.166 -0.085
ENSG00000116830 E027 134.8920310 0.0002285710 3.691713e-01 5.136047e-01 1 117090532 117090623 92 + 2.114 2.095 -0.064
ENSG00000116830 E028 129.9253397 0.0008804198 1.210914e-01 2.214986e-01 1 117091328 117091410 83 + 2.104 2.058 -0.155
ENSG00000116830 E029 191.6167218 0.0029249761 8.345513e-02 1.649647e-01 1 117091817 117091950 134 + 2.276 2.219 -0.191
ENSG00000116830 E030 172.8772762 0.0002519161 1.631123e-02 4.341327e-02 1 117092731 117092786 56 + 2.232 2.171 -0.205
ENSG00000116830 E031 227.3774196 0.0009188701 1.433238e-01 2.525303e-01 1 117092787 117092901 115 + 2.343 2.311 -0.106
ENSG00000116830 E032 131.4167110 0.0007642965 8.544935e-02 1.681306e-01 1 117095309 117095324 16 + 2.112 2.062 -0.170
ENSG00000116830 E033 154.2138340 0.0026401335 7.101671e-02 1.450274e-01 1 117095325 117095367 43 + 2.184 2.123 -0.205
ENSG00000116830 E034 102.1976160 0.0032667124 5.901402e-01 7.130621e-01 1 117096149 117096170 22 + 1.975 2.008 0.112
ENSG00000116830 E035 204.0674696 0.0011740636 7.499691e-02 1.515293e-01 1 117096171 117096299 129 + 2.263 2.327 0.212
ENSG00000116830 E036 189.2229498 0.0005168924 7.802353e-03 2.328140e-02 1 117097351 117097433 83 + 2.222 2.308 0.287
ENSG00000116830 E037 11.5520000 0.0014670466 3.595017e-01 5.038284e-01 1 117098206 117098238 33 + 1.038 1.140 0.370
ENSG00000116830 E038 46.3832485 0.0004529170 9.495776e-01 9.724249e-01 1 117098246 117098832 587 + 1.645 1.659 0.047
ENSG00000116830 E039 182.0389596 0.0022546137 1.300665e-03 4.978724e-03 1 117098833 117098907 75 + 2.192 2.313 0.404
ENSG00000116830 E040 245.0038624 0.0001729515 6.370489e-08 6.720889e-07 1 117101380 117101562 183 + 2.314 2.452 0.461
ENSG00000116830 E041 369.7327862 0.0002157582 9.317536e-25 9.955889e-23 1 117101563 117102193 631 + 2.462 2.672 0.698
ENSG00000116830 E042 144.2541374 0.0115603523 2.724413e-04 1.267608e-03 1 117102194 117102266 73 + 2.045 2.282 0.792
ENSG00000116830 E043 240.7550544 0.0043962673 6.608111e-13 1.671188e-11 1 117102267 117102995 729 + 2.240 2.531 0.972
ENSG00000116830 E044 176.8387457 0.0021887882 1.088506e-03 4.264676e-03 1 117102996 117104721 1726 + 2.177 2.301 0.413
ENSG00000116830 E045 17.4442125 0.0076398085 1.089475e-03 4.268209e-03 1 117104722 117104793 72 + 1.113 1.418 1.071
ENSG00000116830 E046 270.8277290 0.0010048684 2.652413e-22 2.185697e-20 1 117104794 117107474 2681 + 2.302 2.564 0.872
ENSG00000116830 E047 0.2987644 0.0273802656 5.769319e-01   1 117118047 117118159 113 + 0.150 0.000 -8.581
ENSG00000116830 E048 2.4346970 0.0060759380 3.782212e-01 5.225021e-01 1 117118160 117119290 1131 + 0.456 0.610 0.727
ENSG00000116830 E049 2.5767597 0.0177368732 5.874678e-02 1.244774e-01 1 117120794 117121806 1013 + 0.388 0.709 1.509
ENSG00000116830 E050 0.9641468 0.0122519185 4.844553e-01 6.224560e-01 1 117139815 117139877 63 + 0.308 0.180 -1.009