ENSG00000116793

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393357 ENSG00000116793 HEK293_OSMI2_2hA HEK293_TMG_2hB PHTF1 protein_coding protein_coding 10.96488 9.283932 12.03827 0.5595601 0.47549 0.3744651 1.6335012 1.47834159 1.8286893 0.17676346 0.12503347 0.3049720 0.14645833 0.160766667 0.1518667 -0.00890000 9.334261e-01 2.710518e-08 FALSE TRUE
ENST00000412670 ENSG00000116793 HEK293_OSMI2_2hA HEK293_TMG_2hB PHTF1 protein_coding protein_coding 10.96488 9.283932 12.03827 0.5595601 0.47549 0.3744651 3.4268477 4.05189704 3.0048861 0.45042465 0.13316884 -0.4300502 0.32860833 0.433766667 0.2495333 -0.18423333 7.410588e-06 2.710518e-08 FALSE TRUE
ENST00000481652 ENSG00000116793 HEK293_OSMI2_2hA HEK293_TMG_2hB PHTF1 protein_coding processed_transcript 10.96488 9.283932 12.03827 0.5595601 0.47549 0.3744651 0.5090994 0.94862310 0.3355678 0.08002028 0.14367039 -1.4719948 0.05097083 0.103966667 0.0273000 -0.07666667 1.911871e-02 2.710518e-08 FALSE TRUE
ENST00000493212 ENSG00000116793 HEK293_OSMI2_2hA HEK293_TMG_2hB PHTF1 protein_coding processed_transcript 10.96488 9.283932 12.03827 0.5595601 0.47549 0.3744651 0.3514529 0.02671264 0.7688057 0.02671264 0.09785938 4.4069148 0.02892083 0.002866667 0.0637000 0.06083333 2.710518e-08 2.710518e-08   FALSE
MSTRG.1846.10 ENSG00000116793 HEK293_OSMI2_2hA HEK293_TMG_2hB PHTF1 protein_coding   10.96488 9.283932 12.03827 0.5595601 0.47549 0.3744651 1.2128629 0.30507027 1.3866535 0.30507027 0.12112995 2.1482286 0.10037083 0.029733333 0.1150667 0.08533333 1.551927e-01 2.710518e-08 FALSE TRUE
MSTRG.1846.7 ENSG00000116793 HEK293_OSMI2_2hA HEK293_TMG_2hB PHTF1 protein_coding   10.96488 9.283932 12.03827 0.5595601 0.47549 0.3744651 2.3533122 0.71527702 3.3424825 0.41409900 0.26853193 2.2086257 0.19913750 0.083066667 0.2794000 0.19633333 3.409213e-01 2.710518e-08 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116793 E001 3.0122672 0.0291062410 2.091784e-01 3.375373e-01 1 113696831 113697201 371 - 0.685 0.467 -0.992
ENSG00000116793 E002 0.3332198 0.0326480083 8.028641e-01   1 113697202 113697204 3 - 0.105 0.142 0.488
ENSG00000116793 E003 24.2929890 0.0079648974 3.978754e-02 9.063137e-02 1 113697205 113697489 285 - 1.323 1.494 0.590
ENSG00000116793 E004 45.8324478 0.0005003133 8.461136e-03 2.494028e-02 1 113697490 113697725 236 - 1.605 1.740 0.457
ENSG00000116793 E005 28.1010274 0.0008179837 2.894354e-01 4.301107e-01 1 113698262 113698387 126 - 1.429 1.498 0.237
ENSG00000116793 E006 20.2143031 0.0013163775 1.096697e-02 3.108454e-02 1 113699704 113699799 96 - 1.229 1.422 0.674
ENSG00000116793 E007 2.8494006 0.0056324756 8.148823e-01 8.827092e-01 1 113699875 113699988 114 - 0.574 0.611 0.165
ENSG00000116793 E008 10.2537103 0.0347375179 1.285923e-01 2.321927e-01 1 113699989 113700192 204 - 0.953 1.155 0.734
ENSG00000116793 E009 11.1019299 0.0090208827 1.162084e-01 2.145686e-01 1 113700193 113700243 51 - 1.003 1.171 0.607
ENSG00000116793 E010 44.1800948 0.0005677905 4.830094e-02 1.061619e-01 1 113700794 113700949 156 - 1.605 1.708 0.350
ENSG00000116793 E011 3.7759639 0.1264554813 1.729163e-02 4.558844e-02 1 113703823 113704080 258 - 0.376 0.863 2.192
ENSG00000116793 E012 37.2438795 0.0006481724 8.270599e-02 1.637841e-01 1 113704081 113704167 87 - 1.531 1.630 0.336
ENSG00000116793 E013 43.5459018 0.0005555239 1.814047e-02 4.743227e-02 1 113704666 113704797 132 - 1.584 1.708 0.423
ENSG00000116793 E014 15.0857155 0.0033139826 3.602878e-09 4.816218e-08 1 113705765 113705889 125 - 0.881 1.427 1.965
ENSG00000116793 E015 119.3908445 0.0002600036 1.491194e-11 3.018832e-10 1 113705890 113706162 273 - 1.971 2.183 0.709
ENSG00000116793 E016 81.2059989 0.0035337134 8.182276e-02 1.624238e-01 1 113706594 113706722 129 - 1.875 1.956 0.273
ENSG00000116793 E017 104.5577979 0.0004305204 3.987942e-01 5.425325e-01 1 113710254 113710475 222 - 2.009 2.039 0.099
ENSG00000116793 E018 53.9794305 0.0024288778 7.709857e-01 8.521641e-01 1 113711746 113711835 90 - 1.730 1.746 0.053
ENSG00000116793 E019 84.1735863 0.0003587939 9.179401e-01 9.521413e-01 1 113711940 113712113 174 - 1.927 1.931 0.015
ENSG00000116793 E020 71.0153405 0.0003717428 1.126975e-01 2.094821e-01 1 113713279 113713438 160 - 1.886 1.820 -0.220
ENSG00000116793 E021 6.1194162 0.0026618238 7.062547e-01 8.044361e-01 1 113713439 113715212 1774 - 0.831 0.878 0.183
ENSG00000116793 E022 60.7924767 0.0003964730 7.580122e-03 2.271986e-02 1 113724759 113724893 135 - 1.842 1.721 -0.406
ENSG00000116793 E023 0.4428904 0.4832511863 2.159094e-01 3.454971e-01 1 113725335 113725668 334 - 0.000 0.259 10.442
ENSG00000116793 E024 3.3244535 0.0054377367 2.989837e-03 1.023464e-02 1 113725669 113725961 293 - 0.375 0.831 2.071
ENSG00000116793 E025 46.6408187 0.0004624581 2.525384e-01 3.889013e-01 1 113726418 113726458 41 - 1.703 1.645 -0.197
ENSG00000116793 E026 57.7486915 0.0008208705 6.752104e-03 2.057948e-02 1 113726459 113726574 116 - 1.828 1.701 -0.427
ENSG00000116793 E027 27.2483360 0.0008179205 2.396220e-01 3.736639e-01 1 113738110 113738125 16 - 1.487 1.409 -0.267
ENSG00000116793 E028 60.1038584 0.0024468048 4.255563e-03 1.385706e-02 1 113738126 113738268 143 - 1.850 1.707 -0.482
ENSG00000116793 E029 47.3987887 0.0005244475 5.259669e-05 2.947316e-04 1 113738730 113738799 70 - 1.771 1.562 -0.710
ENSG00000116793 E030 7.0277593 0.0023404610 1.911497e-04 9.260857e-04 1 113749522 113749589 68 - 1.059 0.568 -1.952
ENSG00000116793 E031 45.0718255 0.0005179869 2.539278e-07 2.385694e-06 1 113757699 113757755 57 - 1.767 1.487 -0.952
ENSG00000116793 E032 40.5532908 0.0019490148 1.429911e-05 9.162916e-05 1 113758659 113758733 75 - 1.715 1.453 -0.892
ENSG00000116793 E033 18.2821869 0.0049393385 1.414749e-01 2.500395e-01 1 113758734 113758848 115 - 1.335 1.206 -0.453
ENSG00000116793 E034 7.4879654 0.0022601530 7.123202e-03 2.154497e-02 1 113758849 113759022 174 - 1.048 0.719 -1.262
ENSG00000116793 E035 54.6573459 0.0058801194 1.163755e-03 4.518010e-03 1 113759023 113759489 467 - 1.826 1.629 -0.665