ENSG00000116786

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375793 ENSG00000116786 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHM2 protein_coding protein_coding 40.25346 68.99421 21.96095 3.266687 0.6139278 -1.651087 14.704750 24.2522175 7.744071 7.8847384 0.9796444 -1.6456856 0.37825417 0.342700000 0.35366667 0.01096667 9.617777e-01 4.122396e-06 FALSE TRUE
ENST00000375799 ENSG00000116786 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHM2 protein_coding protein_coding 40.25346 68.99421 21.96095 3.266687 0.6139278 -1.651087 2.042296 0.2073771 4.941669 0.1043701 1.1485638 4.5096428 0.06744167 0.002933333 0.22800000 0.22506667 4.122396e-06 4.122396e-06 FALSE TRUE
ENST00000477849 ENSG00000116786 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHM2 protein_coding processed_transcript 40.25346 68.99421 21.96095 3.266687 0.6139278 -1.651087 8.145473 18.8485048 1.924226 2.3030657 0.2753448 -3.2853870 0.16115000 0.274433333 0.08720000 -0.18723333 2.505143e-05 4.122396e-06 FALSE TRUE
ENST00000642363 ENSG00000116786 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHM2 protein_coding protein_coding 40.25346 68.99421 21.96095 3.266687 0.6139278 -1.651087 1.628104 3.8357013 0.000000 3.8357013 0.0000000 -8.5871029 0.02995000 0.050900000 0.00000000 -0.05090000 9.893106e-01 4.122396e-06 FALSE TRUE
MSTRG.366.3 ENSG00000116786 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHM2 protein_coding   40.25346 68.99421 21.96095 3.266687 0.6139278 -1.651087 7.596773 10.1738970 5.663495 5.3352187 0.5542585 -0.8439801 0.21287917 0.154066667 0.25693333 0.10286667 7.647796e-01 4.122396e-06 FALSE TRUE
MSTRG.366.5 ENSG00000116786 HEK293_OSMI2_2hA HEK293_TMG_2hB PLEKHM2 protein_coding   40.25346 68.99421 21.96095 3.266687 0.6139278 -1.651087 5.906945 11.4227653 1.143402 3.9732182 1.1434020 -3.3092071 0.14335417 0.171133333 0.05013333 -0.12100000 1.658457e-01 4.122396e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116786 E001 5.414565 0.0044895783 9.933908e-19 5.494742e-17 1 15684320 15684389 70 + 1.308 0.138 -5.697
ENSG00000116786 E002 9.226585 0.0200693437 6.133301e-12 1.321282e-10 1 15684390 15684537 148 + 1.415 0.580 -3.158
ENSG00000116786 E003 6.902548 0.0104053957 7.586115e-04 3.110145e-03 1 15684538 15684540 3 + 1.112 0.692 -1.608
ENSG00000116786 E004 18.735816 0.0162470398 2.573098e-03 8.983557e-03 1 15684541 15684555 15 + 1.424 1.126 -1.046
ENSG00000116786 E005 111.518811 0.0025339487 3.183828e-02 7.554125e-02 1 15684556 15684618 63 + 2.026 1.939 -0.291
ENSG00000116786 E006 201.872681 0.0015953462 5.441813e-04 2.325173e-03 1 15716237 15716343 107 + 2.299 2.192 -0.357
ENSG00000116786 E007 227.774697 0.0008317006 2.865428e-04 1.325148e-03 1 15716707 15716816 110 + 2.345 2.246 -0.328
ENSG00000116786 E008 204.873195 0.0003284880 5.224128e-03 1.654096e-02 1 15717893 15717992 100 + 2.281 2.208 -0.245
ENSG00000116786 E009 233.169724 0.0003672989 4.371403e-04 1.917278e-03 1 15718538 15718625 88 + 2.347 2.258 -0.296
ENSG00000116786 E010 362.578095 0.0019540067 4.816624e-05 2.725004e-04 1 15719734 15719920 187 + 2.553 2.445 -0.358
ENSG00000116786 E011 67.377129 0.0068075748 3.923657e-01 5.363212e-01 1 15721329 15721388 60 + 1.783 1.739 -0.149
ENSG00000116786 E012 371.896047 0.0019678739 1.780037e-04 8.695117e-04 1 15725317 15725545 229 + 2.557 2.459 -0.326
ENSG00000116786 E013 180.478573 0.0002108806 1.040401e-03 4.098837e-03 1 15727014 15727068 55 + 2.239 2.147 -0.306
ENSG00000116786 E014 204.701949 0.0006820723 3.157046e-01 4.584809e-01 1 15727069 15727191 123 + 2.237 2.215 -0.075
ENSG00000116786 E015 794.829941 0.0013359244 9.112795e-01 9.476545e-01 1 15727192 15727832 641 + 2.803 2.813 0.034
ENSG00000116786 E016 306.691696 0.0004408348 8.485144e-01 9.059611e-01 1 15728079 15728148 70 + 2.396 2.400 0.013
ENSG00000116786 E017 292.632159 0.0001811742 7.671828e-01 8.494724e-01 1 15728267 15728357 91 + 2.363 2.379 0.053
ENSG00000116786 E018 248.351075 0.0001758615 6.225624e-02 1.304311e-01 1 15728669 15728733 65 + 2.257 2.317 0.200
ENSG00000116786 E019 253.699032 0.0001811907 2.098786e-01 3.384047e-01 1 15729102 15729190 89 + 2.282 2.324 0.141
ENSG00000116786 E020 264.646160 0.0001945563 4.680111e-01 6.074410e-01 1 15729797 15729844 48 + 2.342 2.332 -0.036
ENSG00000116786 E021 367.026864 0.0008477377 2.098323e-02 5.355369e-02 1 15729845 15729929 85 + 2.514 2.466 -0.161
ENSG00000116786 E022 483.812960 0.0001442796 2.682888e-03 9.322513e-03 1 15730532 15730722 191 + 2.633 2.584 -0.161
ENSG00000116786 E023 293.200568 0.0002008973 5.998297e-01 7.211637e-01 1 15731192 15731257 66 + 2.361 2.383 0.072
ENSG00000116786 E024 277.849688 0.0002039844 1.782854e-02 4.677030e-02 1 15731889 15731949 61 + 2.297 2.368 0.237
ENSG00000116786 E025 351.209242 0.0001464331 3.113566e-02 7.416770e-02 1 15731950 15732048 99 + 2.408 2.466 0.195
ENSG00000116786 E026 519.600545 0.0001484679 3.795001e-03 1.256799e-02 1 15732350 15732529 180 + 2.574 2.638 0.214
ENSG00000116786 E027 174.190188 0.0015870087 5.677257e-02 1.210712e-01 1 15732612 15732614 3 + 2.087 2.169 0.275
ENSG00000116786 E028 432.243648 0.0002402852 3.575611e-04 1.609305e-03 1 15732615 15732728 114 + 2.477 2.563 0.287
ENSG00000116786 E029 1471.399893 0.0018146297 6.196883e-11 1.130241e-09 1 15733797 15734769 973 + 2.957 3.109 0.504