ENSG00000116752

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369541 ENSG00000116752 HEK293_OSMI2_2hA HEK293_TMG_2hB BCAS2 protein_coding protein_coding 64.63463 36.38489 107.7377 3.113866 3.748988 1.56585 53.889155 33.3434582 85.82002 2.4285796 3.508124 1.363646 0.8443875 0.91860000 0.7963667 -0.1222333 0.000177413 0.000177413 FALSE TRUE
MSTRG.1862.3 ENSG00000116752 HEK293_OSMI2_2hA HEK293_TMG_2hB BCAS2 protein_coding   64.63463 36.38489 107.7377 3.113866 3.748988 1.56585 3.561078 0.6112432 11.09495 0.6112432 2.151434 4.159901 0.0453125 0.01516667 0.1037667 0.0886000 0.077372276 0.000177413 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116752 E001 0.4418608 0.0245487151 3.237745e-01 4.671052e-01 1 114545208 114545217 10 - 0.212 0.000 -9.534
ENSG00000116752 E002 0.9265960 0.0598357130 4.917778e-01 6.290441e-01 1 114545218 114545348 131 - 0.312 0.177 -1.058
ENSG00000116752 E003 0.1451727 0.0428884243 1.000000e+00   1 114546204 114546234 31 - 0.083 0.000 -7.947
ENSG00000116752 E004 0.6674587 0.0319112401 8.502299e-01 9.071038e-01 1 114547923 114547960 38 - 0.212 0.178 -0.319
ENSG00000116752 E005 1.0425102 0.0123042212 3.425789e-01 4.865801e-01 1 114547961 114548115 155 - 0.354 0.177 -1.323
ENSG00000116752 E006 2.7504027 0.0089719851 2.052274e-01 3.326977e-01 1 114548116 114548197 82 - 0.618 0.400 -1.060
ENSG00000116752 E007 18.8229712 0.0052404104 1.671844e-08 1.976942e-07 1 114566332 114566590 259 - 1.404 0.781 -2.275
ENSG00000116752 E008 375.8609799 0.0023809871 1.940350e-03 7.041484e-03 1 114567557 114567883 327 - 2.517 2.616 0.327
ENSG00000116752 E009 569.5152608 0.0016961704 2.992676e-04 1.376669e-03 1 114567884 114568113 230 - 2.700 2.790 0.300
ENSG00000116752 E010 584.8072349 0.0001693179 3.752376e-04 1.678263e-03 1 114568114 114568256 143 - 2.720 2.783 0.208
ENSG00000116752 E011 482.9705317 0.0001254963 1.907910e-01 3.147381e-01 1 114569992 114570072 81 - 2.649 2.679 0.099
ENSG00000116752 E012 381.4664491 0.0001568592 4.134102e-01 5.569097e-01 1 114570700 114570750 51 - 2.560 2.551 -0.027
ENSG00000116752 E013 20.2792154 0.0151517915 3.130036e-01 4.555221e-01 1 114574132 114574378 247 - 1.266 1.381 0.401
ENSG00000116752 E014 667.5424752 0.0001146615 5.916165e-03 1.838944e-02 1 114575590 114575751 162 - 2.810 2.778 -0.106
ENSG00000116752 E015 451.5178105 0.0001559371 1.512287e-05 9.644783e-05 1 114576688 114576758 71 - 2.652 2.582 -0.235
ENSG00000116752 E016 464.3941279 0.0004896399 1.237428e-03 4.767296e-03 1 114581299 114581391 93 - 2.660 2.604 -0.186
ENSG00000116752 E017 337.7061207 0.0014321492 4.106263e-03 1.344114e-02 1 114581499 114581656 158 - 2.526 2.457 -0.232