ENSG00000116731

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311066 ENSG00000116731 HEK293_OSMI2_2hA HEK293_TMG_2hB PRDM2 protein_coding protein_coding 9.104141 9.120601 9.540378 0.05137468 0.2987318 0.06484798 0.6228150 0.1406830 1.39759852 0.14068304 0.31416214 3.2236470 0.06602917 0.01536667 0.14570000 0.13033333 0.0477699410 0.0003453167 FALSE TRUE
ENST00000413440 ENSG00000116731 HEK293_OSMI2_2hA HEK293_TMG_2hB PRDM2 protein_coding protein_coding 9.104141 9.120601 9.540378 0.05137468 0.2987318 0.06484798 4.5545628 3.4045116 5.63486863 0.31444091 0.13174566 0.7252608 0.49857917 0.37313333 0.59123333 0.21810000 0.0003453167 0.0003453167 FALSE TRUE
ENST00000491134 ENSG00000116731 HEK293_OSMI2_2hA HEK293_TMG_2hB PRDM2 protein_coding nonsense_mediated_decay 9.104141 9.120601 9.540378 0.05137468 0.2987318 0.06484798 0.1940652 0.6048283 0.00000000 0.31590072 0.00000000 -5.9421116 0.02136667 0.06646667 0.00000000 -0.06646667 0.1433553371 0.0003453167   FALSE
ENST00000505823 ENSG00000116731 HEK293_OSMI2_2hA HEK293_TMG_2hB PRDM2 protein_coding protein_coding 9.104141 9.120601 9.540378 0.05137468 0.2987318 0.06484798 1.4714983 3.0870579 0.33294401 0.09837068 0.18227533 -3.1748534 0.16367917 0.33843333 0.03393333 -0.30450000 0.0110131102 0.0003453167 FALSE FALSE
MSTRG.340.5 ENSG00000116731 HEK293_OSMI2_2hA HEK293_TMG_2hB PRDM2 protein_coding   9.104141 9.120601 9.540378 0.05137468 0.2987318 0.06484798 0.8495914 0.5324159 0.80271697 0.27049545 0.25309956 0.5833535 0.09220000 0.05860000 0.08513333 0.02653333 0.7832496191 0.0003453167 FALSE TRUE
MSTRG.340.6 ENSG00000116731 HEK293_OSMI2_2hA HEK293_TMG_2hB PRDM2 protein_coding   9.104141 9.120601 9.540378 0.05137468 0.2987318 0.06484798 0.7149882 1.1573912 0.09126406 0.04336362 0.09126406 -3.5270940 0.07924167 0.12696667 0.00980000 -0.11716667 0.0135009441 0.0003453167 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116731 E001 0.0000000       1 13700188 13700197 10 +      
ENSG00000116731 E002 1.1739533 0.0116718781 5.374508e-03 1.694743e-02 1 13700198 13700221 24 + 0.558 0.000 -13.266
ENSG00000116731 E003 1.3556576 0.0106357923 3.758906e-02 8.656336e-02 1 13700222 13700229 8 + 0.558 0.122 -3.008
ENSG00000116731 E004 1.8027153 0.0079064514 5.260886e-02 1.138024e-01 1 13700230 13700239 10 + 0.630 0.217 -2.331
ENSG00000116731 E005 2.7949747 0.0056299380 6.604748e-02 1.367890e-01 1 13700240 13700300 61 + 0.746 0.361 -1.816
ENSG00000116731 E006 0.2214452 0.0403464439 3.749973e-01   1 13704855 13705645 791 + 0.000 0.122 10.998
ENSG00000116731 E007 2.2058543 0.0082141487 1.702119e-03 6.289964e-03 1 13715541 13715614 74 + 0.746 0.122 -3.817
ENSG00000116731 E008 3.4873107 0.0655925473 4.008003e-01 5.444758e-01 1 13731000 13731017 18 + 0.770 0.516 -1.100
ENSG00000116731 E009 10.7223876 0.0029111318 5.478364e-01 6.778157e-01 1 13731018 13731117 100 + 1.148 0.975 -0.629
ENSG00000116731 E010 11.7062254 0.0120443133 9.128305e-01 9.487738e-01 1 13732779 13732855 77 + 1.148 1.046 -0.369
ENSG00000116731 E011 6.6841978 0.0192054182 6.917623e-01 7.931790e-01 1 13732856 13732882 27 + 0.912 0.856 -0.216
ENSG00000116731 E012 0.0000000       1 13738750 13738784 35 +      
ENSG00000116731 E013 0.0000000       1 13738785 13738940 156 +      
ENSG00000116731 E014 12.8122711 0.0013886720 2.325997e-01 3.655478e-01 1 13742005 13742157 153 + 1.138 1.135 -0.008
ENSG00000116731 E015 5.8258486 0.0036839209 4.212742e-01 5.644051e-01 1 13749361 13749402 42 + 0.837 0.835 -0.009
ENSG00000116731 E016 5.3517356 0.0033743646 3.458187e-01 4.899548e-01 1 13749403 13749414 12 + 0.794 0.814 0.078
ENSG00000116731 E017 5.6086829 0.0029950481 5.306618e-01 6.632248e-01 1 13749415 13749423 9 + 0.837 0.814 -0.092
ENSG00000116731 E018 7.0511335 0.0095341271 5.785909e-01 7.036534e-01 1 13749424 13749434 11 + 0.930 0.892 -0.143
ENSG00000116731 E019 7.9315191 0.0065693927 9.205964e-01 9.538939e-01 1 13749435 13749435 1 + 1.006 0.910 -0.359
ENSG00000116731 E020 24.4459996 0.0157201401 2.383744e-01 3.722577e-01 1 13749436 13749487 52 + 1.518 1.294 -0.776
ENSG00000116731 E021 0.1515154 0.0434483000 6.258555e-01   1 13769039 13769117 79 + 0.123 0.000 -11.992
ENSG00000116731 E022 1.0663564 0.0116831985 4.298112e-01 5.724697e-01 1 13769118 13769173 56 + 0.420 0.217 -1.331
ENSG00000116731 E023 1.0373134 0.0125448329 9.854095e-03 2.840536e-02 1 13771726 13772214 489 + 0.517 0.000 -14.995
ENSG00000116731 E024 39.2343640 0.0065115072 1.141875e-03 4.443903e-03 1 13773078 13773188 111 + 1.757 1.420 -1.150
ENSG00000116731 E025 0.2998086 0.0293176014 8.441727e-01   1 13773189 13773671 483 + 0.123 0.122 -0.012
ENSG00000116731 E026 754.6171363 0.0063941120 7.161072e-20 4.471469e-18 1 13778418 13782831 4414 + 3.018 2.710 -1.023
ENSG00000116731 E027 225.7301347 0.0003287435 3.578134e-19 2.079346e-17 1 13786515 13788079 1565 + 2.306 2.389 0.276
ENSG00000116731 E028 31.1666569 0.0012760088 4.410768e-10 6.976761e-09 1 13816427 13816570 144 + 1.320 1.609 0.992
ENSG00000116731 E029 231.5711338 0.0031604906 1.676383e-40 6.014881e-38 1 13823159 13825079 1921 + 2.166 2.479 1.045