ENSG00000116698

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347615 ENSG00000116698 HEK293_OSMI2_2hA HEK293_TMG_2hB SMG7 protein_coding protein_coding 34.03765 39.16253 32.13191 3.154367 0.358896 -0.2853868 9.6609079 8.7910714 9.282135 0.8326297 0.6595059 0.07833091 0.28747500 0.2240000 0.28856667 0.06456667 8.485057e-02 2.090465e-20 FALSE TRUE
ENST00000419169 ENSG00000116698 HEK293_OSMI2_2hA HEK293_TMG_2hB SMG7 protein_coding protein_coding 34.03765 39.16253 32.13191 3.154367 0.358896 -0.2853868 0.8691983 0.0000000 2.343977 0.0000000 0.3887372 7.87895632 0.02893333 0.0000000 0.07273333 0.07273333 2.090465e-20 2.090465e-20 FALSE TRUE
ENST00000444547 ENSG00000116698 HEK293_OSMI2_2hA HEK293_TMG_2hB SMG7 protein_coding nonsense_mediated_decay 34.03765 39.16253 32.13191 3.154367 0.358896 -0.2853868 0.8383684 0.5718326 2.094041 0.3455744 0.1155332 1.85448695 0.02385417 0.0137000 0.06526667 0.05156667 2.131203e-01 2.090465e-20 TRUE FALSE
ENST00000515829 ENSG00000116698 HEK293_OSMI2_2hA HEK293_TMG_2hB SMG7 protein_coding protein_coding 34.03765 39.16253 32.13191 3.154367 0.358896 -0.2853868 17.5338155 26.6042148 13.140491 1.2024497 1.1443911 -1.01708034 0.50237083 0.6830667 0.40960000 -0.27346667 6.279377e-05 2.090465e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116698 E001 3.1208050 0.0079896796 7.205171e-02 1.467440e-01 1 183470793 183471414 622 + 0.717 0.493 -0.993
ENSG00000116698 E002 3.4613125 0.0045234773 4.466337e-02 9.958033e-02 1 183471415 183471454 40 + 0.772 0.533 -1.026
ENSG00000116698 E003 7.8837495 0.0024956075 8.194862e-03 2.427817e-02 1 183471455 183471586 132 + 1.062 0.828 -0.877
ENSG00000116698 E004 10.9025358 0.0016532025 1.310503e-03 5.012130e-03 1 183472216 183472408 193 + 1.197 0.947 -0.910
ENSG00000116698 E005 4.6510546 0.0041694227 2.299031e-01 3.623409e-01 1 183472409 183472477 69 + 0.797 0.692 -0.424
ENSG00000116698 E006 4.2071201 0.0050486565 5.050453e-02 1.100585e-01 1 183472478 183472490 13 + 0.821 0.604 -0.896
ENSG00000116698 E007 4.4285653 0.0062671245 8.094905e-02 1.610184e-01 1 183472491 183472498 8 + 0.821 0.636 -0.758
ENSG00000116698 E008 4.4285653 0.0062671245 8.094905e-02 1.610184e-01 1 183472499 183472499 1 + 0.821 0.636 -0.758
ENSG00000116698 E009 4.5758143 0.0151378759 6.506461e-02 1.351418e-01 1 183472500 183472501 2 + 0.843 0.636 -0.843
ENSG00000116698 E010 4.5758143 0.0151378759 6.506461e-02 1.351418e-01 1 183472502 183472502 1 + 0.843 0.636 -0.843
ENSG00000116698 E011 25.8016262 0.0007766417 1.072763e-05 7.079932e-05 1 183472503 183472526 24 + 1.536 1.308 -0.788
ENSG00000116698 E012 39.8176584 0.0032064080 4.928969e-04 2.133083e-03 1 183472527 183472566 40 + 1.678 1.538 -0.477
ENSG00000116698 E013 72.7682348 0.0073279285 5.200844e-05 2.917633e-04 1 183472567 183472649 83 + 1.946 1.786 -0.540
ENSG00000116698 E014 0.0000000       1 183472932 183472990 59 +      
ENSG00000116698 E015 9.0177199 0.0132661399 3.022846e-03 1.033344e-02 1 183473721 183473898 178 + 1.135 0.848 -1.061
ENSG00000116698 E016 16.9228192 0.0362064358 9.382718e-05 4.929362e-04 1 183501131 183501267 137 + 1.431 1.033 -1.409
ENSG00000116698 E017 11.7241667 0.0113919681 1.951013e-04 9.428675e-04 1 183502253 183502287 35 + 1.260 0.932 -1.189
ENSG00000116698 E018 10.5011100 0.0017636550 5.225844e-04 2.244130e-03 1 183502288 183502299 12 + 1.197 0.916 -1.026
ENSG00000116698 E019 9.6444583 0.0018307858 1.748970e-03 6.437106e-03 1 183502300 183502303 4 + 1.156 0.900 -0.943
ENSG00000116698 E020 20.0444043 0.0009931944 1.294219e-06 1.049507e-05 1 183502304 183502391 88 + 1.469 1.172 -1.035
ENSG00000116698 E021 46.7763576 0.0004923045 1.904989e-08 2.230359e-07 1 183512837 183512840 4 + 1.785 1.571 -0.729
ENSG00000116698 E022 71.6468432 0.0017947286 8.521773e-13 2.116723e-11 1 183512841 183512868 28 + 1.984 1.731 -0.854
ENSG00000116698 E023 0.0000000       1 183512869 183513356 488 +      
ENSG00000116698 E024 153.7466268 0.0157686783 1.294394e-05 8.376688e-05 1 183515874 183515991 118 + 2.293 2.084 -0.697
ENSG00000116698 E025 0.8878743 0.0131216310 2.598518e-03 9.060783e-03 1 183515992 183516086 95 + 0.492 0.000 -16.972
ENSG00000116698 E026 11.7952543 0.0015407396 2.590684e-04 1.212923e-03 1 183517626 183517687 62 + 1.243 0.961 -1.018
ENSG00000116698 E027 189.8138345 0.0057943029 1.428299e-09 2.056913e-08 1 183517688 183517820 133 + 2.377 2.182 -0.652
ENSG00000116698 E028 0.4804688 0.0222385757 3.973147e-01 5.410754e-01 1 183518616 183518682 67 + 0.231 0.115 -1.218
ENSG00000116698 E029 178.6259771 0.0023637660 2.047001e-13 5.568613e-12 1 183526596 183526767 172 + 2.346 2.163 -0.610
ENSG00000116698 E030 6.0004964 0.0027453529 1.552834e-02 4.168801e-02 1 183527626 183527731 106 + 0.958 0.718 -0.934
ENSG00000116698 E031 130.0172136 0.0056875558 3.755179e-08 4.149358e-07 1 183527956 183528027 72 + 2.210 2.025 -0.619
ENSG00000116698 E032 188.7402210 0.0063069124 1.073161e-07 1.084073e-06 1 183528892 183529042 151 + 2.362 2.194 -0.562
ENSG00000116698 E033 207.7797631 0.0006237848 1.482595e-12 3.532552e-11 1 183529398 183529533 136 + 2.377 2.261 -0.387
ENSG00000116698 E034 230.4426772 0.0021432016 2.443181e-10 4.031135e-09 1 183533164 183533326 163 + 2.428 2.301 -0.426
ENSG00000116698 E035 259.7945742 0.0046986159 4.083978e-06 2.962882e-05 1 183533676 183533832 157 + 2.469 2.362 -0.357
ENSG00000116698 E036 188.4824382 0.0050173869 8.340348e-06 5.642445e-05 1 183537145 183537215 71 + 2.335 2.221 -0.380
ENSG00000116698 E037 183.8228689 0.0057982744 4.369006e-06 3.151083e-05 1 183538380 183538440 61 + 2.332 2.201 -0.435
ENSG00000116698 E038 209.4775227 0.0063446851 5.329088e-05 2.981894e-04 1 183540984 183541103 120 + 2.375 2.269 -0.353
ENSG00000116698 E039 339.0211670 0.0025143511 9.340589e-07 7.799482e-06 1 183542076 183542364 289 + 2.566 2.493 -0.245
ENSG00000116698 E040 82.0651492 0.0003028855 4.622488e-08 5.020159e-07 1 183542365 183542502 138 + 1.991 1.851 -0.469
ENSG00000116698 E041 245.0420539 0.0005462521 8.980336e-06 6.035539e-05 1 183544353 183544497 145 + 2.407 2.371 -0.121
ENSG00000116698 E042 433.6212664 0.0018693503 1.789825e-02 4.691874e-02 1 183544930 183545312 383 + 2.626 2.638 0.040
ENSG00000116698 E043 388.1815087 0.0002275045 4.109423e-01 5.545355e-01 1 183545966 183546337 372 + 2.548 2.606 0.193
ENSG00000116698 E044 17.2473426 0.0026593820 1.684748e-01 2.861848e-01 1 183547103 183547252 150 + 1.277 1.231 -0.161
ENSG00000116698 E045 3.5042651 0.0044186218 8.038076e-05 4.297052e-04 1 183548941 183549207 267 + 0.885 0.344 -2.466
ENSG00000116698 E046 189.2921194 0.0008979335 7.143013e-01 8.105506e-01 1 183549208 183549288 81 + 2.221 2.306 0.283
ENSG00000116698 E047 307.6767952 0.0013021884 8.422213e-01 9.016620e-01 1 183549764 183549923 160 + 2.435 2.514 0.266
ENSG00000116698 E048 0.5169874 0.0217020345 7.649107e-01 8.478393e-01 1 183549924 183550088 165 + 0.131 0.205 0.782
ENSG00000116698 E049 287.9547415 0.0001536953 2.093361e-02 5.344830e-02 1 183550751 183550834 84 + 2.379 2.503 0.413
ENSG00000116698 E050 281.2520097 0.0001890870 3.281266e-04 1.493324e-03 1 183550835 183550921 87 + 2.349 2.503 0.513
ENSG00000116698 E051 318.2395750 0.0006253596 1.021491e-01 1.937809e-01 1 183551045 183551190 146 + 2.429 2.540 0.370
ENSG00000116698 E052 1194.4905014 0.0011892614 1.678347e-14 5.357333e-13 1 183551818 183552976 1159 + 2.936 3.147 0.699
ENSG00000116698 E053 1816.4400795 0.0127363027 2.666881e-13 7.141096e-12 1 183552977 183554193 1217 + 2.967 3.381 1.377
ENSG00000116698 E054 0.0000000       1 183597769 183597855 87 +      
ENSG00000116698 E055 0.0000000       1 183598011 183598246 236 +