ENSG00000116691

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000235332 ENSG00000116691 HEK293_OSMI2_2hA HEK293_TMG_2hB MIIP protein_coding protein_coding 41.87468 65.51444 21.11235 4.584782 0.3149923 -1.633263 27.893714 46.894501 12.685787 3.4674661 0.7873675 -1.8853765 0.6399917 0.7155333 0.6002667 -0.11526667 0.0326148274 0.0008297028 FALSE TRUE
ENST00000466860 ENSG00000116691 HEK293_OSMI2_2hA HEK293_TMG_2hB MIIP protein_coding processed_transcript 41.87468 65.51444 21.11235 4.584782 0.3149923 -1.633263 5.587732 7.274487 3.818990 0.9911133 0.2073208 -0.9278635 0.1482417 0.1100667 0.1808000 0.07073333 0.0008297028 0.0008297028 TRUE FALSE
ENST00000478749 ENSG00000116691 HEK293_OSMI2_2hA HEK293_TMG_2hB MIIP protein_coding processed_transcript 41.87468 65.51444 21.11235 4.584782 0.3149923 -1.633263 3.253943 4.039083 2.207128 0.1937498 0.6535926 -0.8689030 0.0884500 0.0619000 0.1048000 0.04290000 0.5585608950 0.0008297028 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116691 E001 22.801646 0.0008464939 6.567985e-01 7.662798e-01 1 12019466 12019497 32 + 1.236 1.271 0.126
ENSG00000116691 E002 96.597194 0.0003288852 7.514121e-01 8.378571e-01 1 12019498 12019552 55 + 1.890 1.872 -0.061
ENSG00000116691 E003 278.245630 0.0002248478 8.687753e-01 9.196492e-01 1 12021645 12021840 196 + 2.336 2.328 -0.027
ENSG00000116691 E004 330.685530 0.0002089920 3.879211e-01 5.320347e-01 1 12022095 12022221 127 + 2.424 2.399 -0.081
ENSG00000116691 E005 441.744209 0.0002903445 7.892494e-01 8.651029e-01 1 12022222 12022442 221 + 2.539 2.531 -0.029
ENSG00000116691 E006 167.138571 0.0011527394 8.455968e-01 9.039884e-01 1 12022833 12022863 31 + 2.122 2.111 -0.038
ENSG00000116691 E007 225.500546 0.0010674577 2.956867e-01 4.368370e-01 1 12022864 12022917 54 + 2.271 2.234 -0.124
ENSG00000116691 E008 8.025549 0.0328885093 2.038434e-01 3.310093e-01 1 12028721 12029032 312 + 0.988 0.804 -0.701
ENSG00000116691 E009 294.831973 0.0010309750 6.977077e-03 2.116348e-02 1 12029033 12029095 63 + 2.418 2.340 -0.261
ENSG00000116691 E010 279.962452 0.0014938130 5.117090e-02 1.112470e-01 1 12029096 12029141 46 + 2.383 2.321 -0.205
ENSG00000116691 E011 279.420016 0.0003991080 6.520940e-01 7.628299e-01 1 12029223 12029281 59 + 2.343 2.328 -0.051
ENSG00000116691 E012 153.281468 0.0059226285 4.787226e-06 3.423911e-05 1 12029282 12029764 483 + 2.241 2.026 -0.719
ENSG00000116691 E013 340.339201 0.0001892810 7.658578e-02 1.540293e-01 1 12029765 12029894 130 + 2.385 2.424 0.131
ENSG00000116691 E014 60.235071 0.0004429149 2.925758e-02 7.050185e-02 1 12029895 12030027 133 + 1.766 1.645 -0.408
ENSG00000116691 E015 339.007640 0.0021638306 3.930757e-03 1.294797e-02 1 12030028 12030124 97 + 2.344 2.436 0.305
ENSG00000116691 E016 9.340661 0.0422870414 4.087362e-01 5.523532e-01 1 12031127 12031265 139 + 1.015 0.891 -0.466
ENSG00000116691 E017 377.882454 0.0001960360 2.137792e-05 1.316340e-04 1 12031266 12031403 138 + 2.384 2.481 0.322
ENSG00000116691 E018 24.939875 0.0078965248 3.413544e-01 4.852520e-01 1 12031541 12031721 181 + 1.381 1.293 -0.307
ENSG00000116691 E019 376.324416 0.0007054322 3.947734e-05 2.278683e-04 1 12031722 12032045 324 + 2.376 2.480 0.345