ENSG00000116679

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000422754 ENSG00000116679 HEK293_OSMI2_2hA HEK293_TMG_2hB IVNS1ABP protein_coding protein_coding 23.07795 14.93645 29.09089 0.7669134 0.9168771 0.9612606 1.5413075 0.3931549 2.4186451 0.32124528 0.4020686 2.5907453 0.06235417 0.02496667 0.08246667 0.057500000 1.920606e-01 3.55375e-17 FALSE TRUE
ENST00000459929 ENSG00000116679 HEK293_OSMI2_2hA HEK293_TMG_2hB IVNS1ABP protein_coding processed_transcript 23.07795 14.93645 29.09089 0.7669134 0.9168771 0.9612606 0.4844376 0.9204933 0.2928991 0.11504603 0.2928991 -1.6191586 0.03214167 0.06256667 0.01016667 -0.052400000 9.018996e-02 3.55375e-17 FALSE TRUE
ENST00000475046 ENSG00000116679 HEK293_OSMI2_2hA HEK293_TMG_2hB IVNS1ABP protein_coding retained_intron 23.07795 14.93645 29.09089 0.7669134 0.9168771 0.9612606 7.2271231 6.5650769 7.9527026 0.48099270 0.7081139 0.2762504 0.33907500 0.43870000 0.27270000 -0.166000000 2.759992e-04 3.55375e-17 FALSE TRUE
ENST00000480769 ENSG00000116679 HEK293_OSMI2_2hA HEK293_TMG_2hB IVNS1ABP protein_coding retained_intron 23.07795 14.93645 29.09089 0.7669134 0.9168771 0.9612606 5.5396769 3.0153449 6.8927421 0.09796116 0.3685796 1.1900700 0.23450417 0.20296667 0.23746667 0.034500000 5.352680e-01 3.55375e-17 FALSE TRUE
MSTRG.2748.4 ENSG00000116679 HEK293_OSMI2_2hA HEK293_TMG_2hB IVNS1ABP protein_coding   23.07795 14.93645 29.09089 0.7669134 0.9168771 0.9612606 4.2776525 2.9237719 5.5474519 0.10335650 0.6231180 0.9216669 0.18971667 0.19676667 0.19043333 -0.006333333 9.596857e-01 3.55375e-17 FALSE TRUE
MSTRG.2748.5 ENSG00000116679 HEK293_OSMI2_2hA HEK293_TMG_2hB IVNS1ABP protein_coding   23.07795 14.93645 29.09089 0.7669134 0.9168771 0.9612606 1.2187560 0.0000000 2.4563534 0.00000000 0.2878593 7.9462357 0.03959583 0.00000000 0.08443333 0.084433333 3.553750e-17 3.55375e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116679 E001 18.064503 0.0477617306 4.554826e-02 1.012003e-01 1 185296388 185296670 283 - 1.142 1.422 0.980
ENSG00000116679 E002 15.427477 0.0088868615 2.864406e-02 6.929583e-02 1 185296671 185296738 68 - 1.117 1.324 0.730
ENSG00000116679 E003 38.028929 0.0178862334 8.280211e-01 8.919081e-01 1 185296739 185297014 276 - 1.598 1.586 -0.038
ENSG00000116679 E004 120.455090 0.0003006443 1.355492e-02 3.720465e-02 1 185297015 185297770 756 - 2.050 2.126 0.256
ENSG00000116679 E005 104.147187 0.0027436212 1.485052e-04 7.404820e-04 1 185297771 185297957 187 - 1.946 2.102 0.524
ENSG00000116679 E006 57.158570 0.0005267226 3.037475e-03 1.037559e-02 1 185297958 185297974 17 - 1.700 1.835 0.456
ENSG00000116679 E007 65.962536 0.0005405428 1.171278e-05 7.661592e-05 1 185297975 185297987 13 - 1.735 1.922 0.633
ENSG00000116679 E008 330.422790 0.0005424215 1.835207e-12 4.307900e-11 1 185297988 185298288 301 - 2.450 2.595 0.481
ENSG00000116679 E009 4.523211 0.0344614221 1.299444e-01 2.340897e-01 1 185298405 185299709 1305 - 0.638 0.875 0.958
ENSG00000116679 E010 275.712714 0.0002785167 2.594129e-03 9.047813e-03 1 185299710 185299883 174 - 2.413 2.474 0.204
ENSG00000116679 E011 190.459539 0.0002475512 1.297733e-02 3.585881e-02 1 185299999 185300096 98 - 2.253 2.313 0.200
ENSG00000116679 E012 122.169767 0.0009910615 1.470298e-01 2.576411e-01 1 185300097 185300130 34 - 2.067 2.112 0.151
ENSG00000116679 E013 128.900094 0.0011039678 2.793910e-01 4.191429e-01 1 185300217 185300245 29 - 2.096 2.128 0.106
ENSG00000116679 E014 189.687659 0.0002915937 3.323643e-01 4.760083e-01 1 185300246 185300343 98 - 2.269 2.290 0.070
ENSG00000116679 E015 3.440760 0.1357817246 9.272233e-01 9.582150e-01 1 185300344 185300436 93 - 0.612 0.646 0.147
ENSG00000116679 E016 196.078063 0.0002466551 8.039206e-01 8.752342e-01 1 185300437 185300558 122 - 2.297 2.287 -0.035
ENSG00000116679 E017 0.000000       1 185300559 185300918 360 -      
ENSG00000116679 E018 206.784796 0.0005868350 9.984882e-02 1.902506e-01 1 185300972 185301196 225 - 2.338 2.290 -0.158
ENSG00000116679 E019 4.218854 0.0036542024 1.158145e-03 4.499091e-03 1 185301197 185301433 237 - 0.871 0.349 -2.382
ENSG00000116679 E020 166.245639 0.0030469190 8.344053e-01 8.963385e-01 1 185301434 185301563 130 - 2.226 2.213 -0.043
ENSG00000116679 E021 16.790754 0.0011090007 1.926536e-04 9.324421e-04 1 185301564 185301714 151 - 1.360 1.020 -1.209
ENSG00000116679 E022 138.871458 0.0022857892 6.054053e-01 7.257990e-01 1 185305536 185305643 108 - 2.153 2.128 -0.081
ENSG00000116679 E023 120.623732 0.0060522561 3.828176e-10 6.127379e-09 1 185305644 185306484 841 - 2.193 1.861 -1.115
ENSG00000116679 E024 48.748182 0.0004886622 4.098080e-09 5.422707e-08 1 185306485 185306625 141 - 1.805 1.480 -1.105
ENSG00000116679 E025 7.075858 0.0195494395 6.256040e-03 1.928483e-02 1 185306750 185307013 264 - 1.033 0.633 -1.572
ENSG00000116679 E026 100.026264 0.0002793840 2.263762e-01 3.580601e-01 1 185307014 185307079 66 - 1.986 2.025 0.131
ENSG00000116679 E027 84.832292 0.0003971671 2.675946e-01 4.059172e-01 1 185307080 185307139 60 - 1.914 1.953 0.131
ENSG00000116679 E028 130.391261 0.0003471473 3.207824e-01 4.639453e-01 1 185307489 185307662 174 - 2.132 2.096 -0.119
ENSG00000116679 E029 3.021630 0.0202534116 5.764419e-01 7.018735e-01 1 185307680 185308017 338 - 0.638 0.541 -0.437
ENSG00000116679 E030 75.507241 0.0003908607 2.108997e-01 3.396060e-01 1 185308800 185308875 76 - 1.906 1.851 -0.187
ENSG00000116679 E031 86.564364 0.0004756346 4.117684e-02 9.321100e-02 1 185309003 185309172 170 - 1.974 1.889 -0.285
ENSG00000116679 E032 98.075503 0.0087741550 5.253635e-04 2.254378e-03 1 185309383 185309511 129 - 2.070 1.856 -0.721
ENSG00000116679 E033 150.435812 0.0002689026 6.679657e-12 1.431656e-10 1 185311095 185311322 228 - 2.256 2.041 -0.717
ENSG00000116679 E034 99.925491 0.0021154256 4.953575e-09 6.471553e-08 1 185316953 185318670 1718 - 2.094 1.837 -0.863