ENSG00000116668

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367500 ENSG00000116668 HEK293_OSMI2_2hA HEK293_TMG_2hB SWT1 protein_coding protein_coding 1.1932 0.3178367 1.911886 0.02710853 0.1921483 2.551473 0.6804841 0.1209969 0.88616538 0.12099689 0.25118946 2.774232 0.4153542 0.3333333 0.49543333 0.1621000 0.64394200 0.01590602 FALSE TRUE
ENST00000367501 ENSG00000116668 HEK293_OSMI2_2hA HEK293_TMG_2hB SWT1 protein_coding protein_coding 1.1932 0.3178367 1.911886 0.02710853 0.1921483 2.551473 0.2558504 0.0000000 0.85104951 0.00000000 0.36576799 6.428024 0.1761458 0.0000000 0.42063333 0.4206333 0.01590602 0.01590602 FALSE TRUE
ENST00000450350 ENSG00000116668 HEK293_OSMI2_2hA HEK293_TMG_2hB SWT1 protein_coding protein_coding 1.1932 0.3178367 1.911886 0.02710853 0.1921483 2.551473 0.1052252 0.0000000 0.12213166 0.00000000 0.07053053 3.723904 0.0740750 0.0000000 0.05750000 0.0575000 0.71144436 0.01590602 FALSE FALSE
MSTRG.2740.3 ENSG00000116668 HEK293_OSMI2_2hA HEK293_TMG_2hB SWT1 protein_coding   1.1932 0.3178367 1.911886 0.02710853 0.1921483 2.551473 0.1516405 0.1968399 0.05253934 0.09955719 0.05253934 -1.725678 0.3344250 0.6666667 0.02643333 -0.6402333 0.27944987 0.01590602 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116668 E001 0.5975289 0.033697025 5.821298e-01 0.7065422297 1 185157080 185157164 85 + 0.190 0.000 -9.423
ENSG00000116668 E002 0.2987644 0.027870228 1.000000e+00   1 185157167 185157231 65 + 0.105 0.000 -8.421
ENSG00000116668 E003 1.7873873 0.065984541 8.477391e-01 0.9054508386 1 185157232 185157314 83 + 0.350 0.408 0.330
ENSG00000116668 E004 0.4418608 0.024169613 8.938974e-01 0.9361559324 1 185157482 185157626 145 + 0.150 0.000 -9.005
ENSG00000116668 E005 3.5715549 0.078611653 3.655417e-01 0.5098491992 1 185160833 185160840 8 + 0.590 0.408 -0.891
ENSG00000116668 E006 5.1268879 0.113812354 3.393441e-01 0.4832500139 1 185160841 185160925 85 + 0.710 0.527 -0.805
ENSG00000116668 E007 6.0979541 0.003099748 7.299426e-01 0.8220093446 1 185166572 185166652 81 + 0.732 0.806 0.297
ENSG00000116668 E008 3.4375681 0.004945282 4.039582e-01 0.5477288227 1 185168340 185168398 59 + 0.523 0.686 0.723
ENSG00000116668 E009 12.8297965 0.004095936 1.685625e-01 0.2862901566 1 185174372 185174804 433 + 1.053 0.900 -0.568
ENSG00000116668 E010 8.5933266 0.002776560 4.119555e-02 0.0932433230 1 185174805 185175113 309 + 0.918 0.611 -1.239
ENSG00000116668 E011 5.5916790 0.002954260 4.700200e-02 0.1038315674 1 185180391 185180450 60 + 0.764 0.405 -1.640
ENSG00000116668 E012 6.1451996 0.002838482 2.499639e-01 0.3858714737 1 185181946 185182057 112 + 0.784 0.611 -0.721
ENSG00000116668 E013 5.4842846 0.024593863 7.044000e-02 0.1440748603 1 185184243 185184344 102 + 0.754 0.406 -1.594
ENSG00000116668 E014 9.2486069 0.001912133 2.181736e-02 0.0552963068 1 185184743 185184931 189 + 0.953 0.611 -1.370
ENSG00000116668 E015 7.0448289 0.002822711 4.558856e-02 0.1012748359 1 185190549 185190642 94 + 0.848 0.520 -1.386
ENSG00000116668 E016 8.1895196 0.002146932 5.787836e-01 0.7037909655 1 185202654 185202799 146 + 0.864 0.806 -0.227
ENSG00000116668 E017 7.4780392 0.002410563 7.988635e-01 0.8716669325 1 185204700 185204863 164 + 0.822 0.806 -0.061
ENSG00000116668 E018 8.2154276 0.003533570 7.843984e-01 0.8616902200 1 185206625 185206763 139 + 0.839 0.900 0.234
ENSG00000116668 E019 11.2436343 0.001555957 2.002461e-01 0.3265330562 1 185214507 185214655 149 + 1.003 0.855 -0.556
ENSG00000116668 E020 14.0448379 0.001350883 4.293780e-01 0.5721024136 1 185221849 185222036 188 + 1.079 1.011 -0.248
ENSG00000116668 E021 9.0947096 0.002146932 8.454266e-01 0.9038829666 1 185231577 185231708 132 + 0.903 0.900 -0.014
ENSG00000116668 E022 7.9298251 0.002242626 7.564422e-02 0.1525356311 1 185271323 185271389 67 + 0.794 1.042 0.941
ENSG00000116668 E023 9.2700912 0.002005935 4.355458e-03 0.0141364159 1 185276604 185276668 65 + 0.822 1.173 1.301
ENSG00000116668 E024 33.9755773 0.020108439 6.968016e-05 0.0003784604 1 185290674 185291781 1108 + 1.350 1.686 1.152