ENSG00000116584

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313667 ENSG00000116584 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF2 protein_coding protein_coding 17.56176 25.27542 10.26348 1.050614 0.6582197 -1.299381 0.9069225 0.000000 0.7746764 0.0000000 0.4544135 6.294026 0.0655750 0.0000000 0.07686667 0.07686667 0.10784829 6.244823e-05 FALSE TRUE
ENST00000313695 ENSG00000116584 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF2 protein_coding protein_coding 17.56176 25.27542 10.26348 1.050614 0.6582197 -1.299381 2.6983039 4.718793 1.5123558 0.5729561 0.4344892 -1.635166 0.1464750 0.1875333 0.14343333 -0.04410000 0.65467567 6.244823e-05 FALSE TRUE
ENST00000361247 ENSG00000116584 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF2 protein_coding protein_coding 17.56176 25.27542 10.26348 1.050614 0.6582197 -1.299381 7.3057319 11.357582 4.2895908 1.2155690 0.2046822 -1.402654 0.4019375 0.4471667 0.42033333 -0.02683333 0.85451517 6.244823e-05 FALSE TRUE
ENST00000470541 ENSG00000116584 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF2 protein_coding protein_coding 17.56176 25.27542 10.26348 1.050614 0.6582197 -1.299381 2.7128001 6.992307 0.3093361 0.4567476 0.3093361 -4.454683 0.1158833 0.2790333 0.02673333 -0.25230000 0.03185864 6.244823e-05 FALSE TRUE
MSTRG.2344.6 ENSG00000116584 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF2 protein_coding   17.56176 25.27542 10.26348 1.050614 0.6582197 -1.299381 0.9416692 0.000000 0.9925406 0.0000000 0.5377319 6.647517 0.0820250 0.0000000 0.10363333 0.10363333 0.12039897 6.244823e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116584 E001 1.5383150 0.0099139461 2.024099e-01 3.292431e-01 1 155946851 155946853 3 - 0.176 0.430 1.759
ENSG00000116584 E002 1.8672684 0.0136196795 4.202097e-01 5.634332e-01 1 155946854 155946854 1 - 0.301 0.463 0.929
ENSG00000116584 E003 2.1638547 0.0111841269 2.617144e-01 3.993958e-01 1 155946855 155946855 1 - 0.301 0.522 1.217
ENSG00000116584 E004 33.3241290 0.0173837704 1.264466e-04 6.432063e-04 1 155946856 155946921 66 - 1.146 1.561 1.444
ENSG00000116584 E005 155.7606068 0.0070621151 8.238433e-06 5.579873e-05 1 155946922 155947080 159 - 1.935 2.194 0.868
ENSG00000116584 E006 515.9694315 0.0032566742 1.049642e-09 1.550621e-08 1 155947081 155947941 861 - 2.493 2.701 0.693
ENSG00000116584 E007 73.7274052 0.0005363663 8.855116e-01 9.307710e-01 1 155947942 155948015 74 - 1.803 1.813 0.034
ENSG00000116584 E008 18.8163335 0.0009913398 2.382818e-01 3.721437e-01 1 155950269 155950298 30 - 1.146 1.269 0.435
ENSG00000116584 E009 142.6996146 0.0010767351 2.275913e-01 3.595168e-01 1 155950299 155950482 184 - 2.049 2.111 0.206
ENSG00000116584 E010 266.4528566 0.0013446788 3.404330e-02 7.984304e-02 1 155950829 155951272 444 - 2.303 2.385 0.272
ENSG00000116584 E011 129.9712042 0.0004810042 9.122495e-01 9.483850e-01 1 155951483 155951533 51 - 2.045 2.059 0.044
ENSG00000116584 E012 109.9875153 0.0018674381 7.347954e-01 8.256740e-01 1 155951741 155951776 36 - 1.982 1.986 0.011
ENSG00000116584 E013 116.3431706 0.0019159545 9.433610e-01 9.684716e-01 1 155951919 155951986 68 - 1.996 2.016 0.069
ENSG00000116584 E014 132.1270273 0.0030376978 7.368322e-01 8.271892e-01 1 155952116 155952235 120 - 2.044 2.076 0.108
ENSG00000116584 E015 102.0807089 0.0131721509 3.617574e-01 5.061734e-01 1 155952628 155952731 104 - 1.899 1.975 0.256
ENSG00000116584 E016 101.6818837 0.0003238109 1.666788e-01 2.838721e-01 1 155952732 155952802 71 - 1.898 1.970 0.243
ENSG00000116584 E017 82.5246173 0.0003662726 7.934384e-01 8.679269e-01 1 155952803 155952828 26 - 1.854 1.860 0.018
ENSG00000116584 E018 108.2900421 0.0002827138 4.430068e-01 5.845671e-01 1 155954902 155954969 68 - 1.942 1.989 0.156
ENSG00000116584 E019 161.1965863 0.0004940759 6.311762e-01 7.462502e-01 1 155957713 155957882 170 - 2.122 2.155 0.110
ENSG00000116584 E020 92.9123581 0.0004063139 7.445218e-01 8.328380e-01 1 155958320 155958396 77 - 1.887 1.917 0.102
ENSG00000116584 E021 159.6590090 0.0002049138 8.616200e-01 9.147687e-01 1 155961661 155961909 249 - 2.129 2.151 0.075
ENSG00000116584 E022 0.7426990 0.0304367743 8.723940e-01 9.219396e-01 1 155961910 155961938 29 - 0.176 0.214 0.348
ENSG00000116584 E023 1.4758462 0.0091804202 2.711280e-01 4.098315e-01 1 155961939 155962104 166 - 0.176 0.395 1.569
ENSG00000116584 E024 100.2910203 0.0003480742 6.994650e-01 7.991954e-01 1 155962105 155962222 118 - 1.922 1.954 0.109
ENSG00000116584 E025 2.2572590 0.0067514807 6.988615e-03 2.119440e-02 1 155962223 155962592 370 - 0.741 0.314 -2.088
ENSG00000116584 E026 101.6736756 0.0045357895 8.733891e-01 9.226361e-01 1 155962593 155962718 126 - 1.945 1.955 0.035
ENSG00000116584 E027 128.9233752 0.0045369833 2.345181e-01 3.677751e-01 1 155962933 155963126 194 - 2.078 2.043 -0.117
ENSG00000116584 E028 59.7371327 0.0006028244 2.329705e-02 5.837034e-02 1 155963127 155963139 13 - 1.789 1.693 -0.325
ENSG00000116584 E029 78.7934471 0.0003653458 1.545984e-01 2.678759e-01 1 155963140 155963183 44 - 1.872 1.827 -0.153
ENSG00000116584 E030 116.4081479 0.0010689714 3.959751e-02 9.028644e-02 1 155964988 155965128 141 - 2.053 1.992 -0.205
ENSG00000116584 E031 34.8169796 0.0133530467 1.306491e-02 3.606399e-02 1 155965129 155965131 3 - 1.623 1.442 -0.622
ENSG00000116584 E032 67.9235870 0.0025569747 9.334921e-05 4.907381e-04 1 155965303 155965323 21 - 1.903 1.725 -0.602
ENSG00000116584 E033 97.1994773 0.0003527966 6.094227e-07 5.301860e-06 1 155965324 155965412 89 - 2.053 1.881 -0.579
ENSG00000116584 E034 98.9658304 0.0032444777 5.585199e-05 3.109039e-04 1 155965631 155965760 130 - 2.055 1.890 -0.553
ENSG00000116584 E035 72.6979695 0.0003785139 2.660768e-03 9.254880e-03 1 155966416 155966479 64 - 1.889 1.773 -0.393
ENSG00000116584 E036 74.7245102 0.0004659916 2.218078e-04 1.057181e-03 1 155966820 155966887 68 - 1.919 1.774 -0.488
ENSG00000116584 E037 3.8061554 0.0045494692 4.595121e-01 5.996349e-01 1 155968220 155968808 589 - 0.699 0.598 -0.432
ENSG00000116584 E038 2.5410723 0.1257954154 7.224255e-02 1.470654e-01 1 155968809 155969155 347 - 0.741 0.393 -1.612
ENSG00000116584 E039 84.7017489 0.0016640685 9.230764e-07 7.717301e-06 1 155969156 155969247 92 - 2.009 1.811 -0.666
ENSG00000116584 E040 71.7246654 0.0004335432 1.892561e-06 1.480469e-05 1 155969248 155969300 53 - 1.937 1.745 -0.646
ENSG00000116584 E041 0.7728880 0.0153787590 2.048468e-01 3.322086e-01 1 155969534 155969729 196 - 0.000 0.267 12.166
ENSG00000116584 E042 7.8041464 0.0024104497 1.448269e-01 2.545957e-01 1 155969969 155971063 1095 - 1.000 0.841 -0.602
ENSG00000116584 E043 0.8126288 0.2014433675 2.598601e-01 3.973278e-01 1 155972255 155972349 95 - 0.000 0.272 11.299
ENSG00000116584 E044 4.5288824 0.0986456411 3.416057e-01 4.855181e-01 1 155978067 155978169 103 - 0.778 0.636 -0.591
ENSG00000116584 E045 62.8065563 0.0077128804 1.987187e-02 5.121906e-02 1 155978365 155978594 230 - 1.836 1.709 -0.428
ENSG00000116584 E046 1.8047745 0.3946794011 8.025442e-01 8.742264e-01 1 155978913 155979113 201 - 0.477 0.370 -0.572
ENSG00000116584 E047 2.6132703 0.0055920512 6.491022e-06 4.503423e-05 1 155983107 155983200 94 - 0.903 0.214 -3.462
ENSG00000116584 E048 0.1472490 0.0430507405 1.967019e-01   1 155984394 155984433 40 - 0.176 0.000 -12.351
ENSG00000116584 E049 0.6362506 0.4993923419 2.203888e-01 3.508688e-01 1 155985332 155985374 43 - 0.400 0.084 -2.829
ENSG00000116584 E050 0.6362506 0.4993923419 2.203888e-01 3.508688e-01 1 155985375 155985449 75 - 0.400 0.084 -2.829
ENSG00000116584 E051 0.7834997 0.1232541472 3.270871e-02 7.721770e-02 1 155989234 155989351 118 - 0.478 0.084 -3.241
ENSG00000116584 E052 0.0000000       1 155989352 155989499 148 -      
ENSG00000116584 E053 0.0000000       1 155989991 155990073 83 -      
ENSG00000116584 E054 0.4804688 0.0210936763 1.810014e-01 3.024678e-01 1 155990841 155991212 372 - 0.301 0.083 -2.240
ENSG00000116584 E055 0.3268771 0.0300400810 5.123926e-01   1 155996095 155996627 533 - 0.176 0.083 -1.239
ENSG00000116584 E056 0.0000000       1 156002441 156002564 124 -      
ENSG00000116584 E057 0.4804688 0.0210936763 1.810014e-01 3.024678e-01 1 156003643 156003729 87 - 0.301 0.083 -2.240
ENSG00000116584 E058 0.1515154 0.0431092191 1.965173e-01   1 156006931 156007070 140 - 0.176 0.000 -12.351