ENSG00000116580

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368331 ENSG00000116580 HEK293_OSMI2_2hA HEK293_TMG_2hB GON4L protein_coding protein_coding 16.06769 16.27202 14.08841 0.614332 0.6689069 -0.2077472 1.6144511 1.1771920 1.5264911 0.07499194 0.81694562 0.3720861 0.104566667 0.072733333 0.11310000 0.0403666667 9.923082e-01 9.610281e-07 FALSE TRUE
ENST00000437809 ENSG00000116580 HEK293_OSMI2_2hA HEK293_TMG_2hB GON4L protein_coding protein_coding 16.06769 16.27202 14.08841 0.614332 0.6689069 -0.2077472 4.4891646 5.2852561 2.9565818 0.65842074 0.57127735 -0.8358989 0.276100000 0.325366667 0.20690000 -0.1184666667 2.116927e-01 9.610281e-07 FALSE TRUE
ENST00000460075 ENSG00000116580 HEK293_OSMI2_2hA HEK293_TMG_2hB GON4L protein_coding retained_intron 16.06769 16.27202 14.08841 0.614332 0.6689069 -0.2077472 1.5037068 1.1652437 1.0036799 0.02687390 0.08726131 -0.2133577 0.089900000 0.071900000 0.07103333 -0.0008666667 1.000000e+00 9.610281e-07 FALSE TRUE
ENST00000473267 ENSG00000116580 HEK293_OSMI2_2hA HEK293_TMG_2hB GON4L protein_coding retained_intron 16.06769 16.27202 14.08841 0.614332 0.6689069 -0.2077472 3.1063308 5.4490562 1.2646754 0.92092567 0.16204922 -2.0985216 0.180058333 0.332600000 0.08910000 -0.2435000000 9.610281e-07 9.610281e-07 TRUE FALSE
MSTRG.2339.1 ENSG00000116580 HEK293_OSMI2_2hA HEK293_TMG_2hB GON4L protein_coding   16.06769 16.27202 14.08841 0.614332 0.6689069 -0.2077472 0.8618630 1.1717913 0.2653510 0.18451083 0.26535096 -2.1016317 0.053545833 0.072800000 0.01810000 -0.0547000000 1.532596e-01 9.610281e-07 TRUE TRUE
MSTRG.2339.10 ENSG00000116580 HEK293_OSMI2_2hA HEK293_TMG_2hB GON4L protein_coding   16.06769 16.27202 14.08841 0.614332 0.6689069 -0.2077472 0.1274255 0.0000000 0.8111192 0.00000000 0.81111919 6.3595198 0.008833333 0.000000000 0.05536667 0.0553666667 8.287685e-01 9.610281e-07 FALSE TRUE
MSTRG.2339.2 ENSG00000116580 HEK293_OSMI2_2hA HEK293_TMG_2hB GON4L protein_coding   16.06769 16.27202 14.08841 0.614332 0.6689069 -0.2077472 0.7452544 0.2468980 1.1215625 0.13797505 0.22322203 2.1390485 0.049312500 0.014966667 0.08106667 0.0661000000 9.428739e-02 9.610281e-07 TRUE TRUE
MSTRG.2339.8 ENSG00000116580 HEK293_OSMI2_2hA HEK293_TMG_2hB GON4L protein_coding   16.06769 16.27202 14.08841 0.614332 0.6689069 -0.2077472 0.8216754 0.1304298 1.3203243 0.05098012 0.25898695 3.2438572 0.058125000 0.008266667 0.09586667 0.0876000000 2.964727e-05 9.610281e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116580 E001 65.2907811 0.0023138865 2.257660e-01 3.573025e-01 1 155745764 155748518 2755 - 1.782 1.843 0.208
ENSG00000116580 E002 10.1740867 0.0105080843 8.979537e-01 9.388639e-01 1 155749568 155749658 91 - 1.051 1.039 -0.042
ENSG00000116580 E003 5.0229846 0.0060334842 5.315223e-01 6.639543e-01 1 155749659 155749661 3 - 0.821 0.739 -0.324
ENSG00000116580 E004 7.2340451 0.0633683526 6.415793e-01 7.545740e-01 1 155749662 155749716 55 - 0.950 0.886 -0.245
ENSG00000116580 E005 52.6932915 0.0134178668 1.102564e-08 1.348902e-07 1 155749717 155749941 225 - 1.428 1.876 1.525
ENSG00000116580 E006 74.8974163 0.0082911732 1.624219e-12 3.841490e-11 1 155749942 155750331 390 - 1.576 2.024 1.513
ENSG00000116580 E007 38.5803767 0.0005684270 6.721216e-08 7.058674e-07 1 155750332 155750340 9 - 1.388 1.710 1.101
ENSG00000116580 E008 51.6663855 0.0004828860 6.041457e-11 1.103805e-09 1 155750341 155750392 52 - 1.497 1.839 1.161
ENSG00000116580 E009 31.5548635 0.0006878331 1.550790e-05 9.864436e-05 1 155750393 155750403 11 - 1.332 1.614 0.968
ENSG00000116580 E010 48.2803139 0.0102794783 2.456868e-05 1.493203e-04 1 155750404 155750452 49 - 1.497 1.804 1.043
ENSG00000116580 E011 72.5334336 0.0005029588 2.867564e-09 3.907012e-08 1 155750453 155750623 171 - 1.704 1.964 0.877
ENSG00000116580 E012 58.1280074 0.0045857010 3.853151e-03 1.273007e-02 1 155750624 155750733 110 - 1.671 1.838 0.562
ENSG00000116580 E013 74.0052516 0.0081595592 1.860231e-03 6.789910e-03 1 155751767 155751869 103 - 1.760 1.948 0.635
ENSG00000116580 E014 4.4599147 0.0036079578 1.099945e-01 2.055326e-01 1 155751870 155751959 90 - 0.842 0.624 -0.891
ENSG00000116580 E015 144.2209439 0.0039761778 6.054145e-06 4.230064e-05 1 155751960 155752258 299 - 2.043 2.237 0.649
ENSG00000116580 E016 61.5312453 0.0004436664 3.650687e-06 2.682017e-05 1 155752259 155752438 180 - 1.662 1.879 0.733
ENSG00000116580 E017 69.2339020 0.0005474760 9.036388e-05 4.767508e-04 1 155752439 155752587 149 - 1.737 1.911 0.589
ENSG00000116580 E018 3.9053478 0.0837697714 7.487444e-01 8.358911e-01 1 155752588 155752590 3 - 0.723 0.656 -0.280
ENSG00000116580 E019 124.1872032 0.0026272571 3.131018e-05 1.854558e-04 1 155753204 155753414 211 - 1.992 2.161 0.568
ENSG00000116580 E020 13.2197762 0.0016163114 5.537893e-01 6.828818e-01 1 155754017 155754374 358 - 1.121 1.179 0.206
ENSG00000116580 E021 88.2111560 0.0003495709 3.710079e-04 1.662205e-03 1 155754375 155754488 114 - 1.863 2.003 0.470
ENSG00000116580 E022 3.7424572 0.0856019795 6.473134e-01 7.589998e-01 1 155756541 155756957 417 - 0.725 0.624 -0.423
ENSG00000116580 E023 82.8342512 0.0003957198 1.454461e-02 3.946518e-02 1 155756958 155757077 120 - 1.861 1.961 0.335
ENSG00000116580 E024 3.0449974 0.1773942710 4.707360e-01 6.099580e-01 1 155757078 155757179 102 - 0.667 0.521 -0.654
ENSG00000116580 E025 96.0894627 0.0015659957 6.359944e-02 1.326923e-01 1 155757180 155757323 144 - 1.936 2.014 0.262
ENSG00000116580 E026 73.5415884 0.0083769612 1.200151e-01 2.200115e-01 1 155757891 155758034 144 - 1.811 1.908 0.326
ENSG00000116580 E027 82.5167243 0.0006270194 3.030125e-04 1.391827e-03 1 155760444 155760641 198 - 1.827 1.976 0.504
ENSG00000116580 E028 94.9161349 0.0003419486 2.130932e-04 1.020111e-03 1 155762190 155762374 185 - 1.897 2.038 0.470
ENSG00000116580 E029 123.6268346 0.0036357974 3.088287e-01 4.510923e-01 1 155763312 155763564 253 - 2.068 2.116 0.160
ENSG00000116580 E030 1.8811779 0.0077432998 7.028954e-02 1.438417e-01 1 155764427 155764583 157 - 0.599 0.293 -1.628
ENSG00000116580 E031 1.8843114 0.0098461226 2.256473e-01 3.571606e-01 1 155764584 155764783 200 - 0.561 0.358 -1.044
ENSG00000116580 E032 16.8825107 0.0042405333 3.690162e-01 5.134435e-01 1 155764784 155764999 216 - 1.209 1.291 0.288
ENSG00000116580 E033 209.0017649 0.0006362936 1.151751e-01 2.131026e-01 1 155765000 155765448 449 - 2.295 2.340 0.151
ENSG00000116580 E034 299.7673681 0.0001825313 9.037480e-02 1.757105e-01 1 155765449 155766503 1055 - 2.492 2.461 -0.103
ENSG00000116580 E035 40.8684972 0.0118906824 5.872433e-01 7.105679e-01 1 155766504 155766535 32 - 1.643 1.609 -0.113
ENSG00000116580 E036 55.7863743 0.0088617524 6.299437e-01 7.452335e-01 1 155766536 155766652 117 - 1.767 1.741 -0.087
ENSG00000116580 E037 23.4388973 0.0008621615 1.966342e-01 3.220353e-01 1 155766653 155766709 57 - 1.433 1.346 -0.303
ENSG00000116580 E038 0.6674587 0.0239752166 3.000679e-01 4.417013e-01 1 155767086 155767424 339 - 0.299 0.121 -1.626
ENSG00000116580 E039 22.3278910 0.0274357123 2.958700e-01 4.370126e-01 1 155767425 155767541 117 - 1.411 1.313 -0.341
ENSG00000116580 E040 38.6667518 0.0014313871 7.704204e-02 1.547547e-01 1 155771067 155771217 151 - 1.646 1.548 -0.334
ENSG00000116580 E041 56.1538581 0.0004110742 8.574446e-03 2.522483e-02 1 155773066 155773210 145 - 1.816 1.697 -0.403
ENSG00000116580 E042 1.3565881 0.1384288238 1.533552e-01 2.662379e-01 1 155773211 155773420 210 - 0.520 0.214 -1.856
ENSG00000116580 E043 1.2618922 0.1250618092 1.941545e-01 3.189862e-01 1 155774807 155774962 156 - 0.475 0.216 -1.627
ENSG00000116580 E044 3.0302382 0.0066440329 8.544972e-03 2.515257e-02 1 155774963 155775001 39 - 0.775 0.359 -1.949
ENSG00000116580 E045 43.1532552 0.0005152413 5.252141e-02 1.136509e-01 1 155775002 155775169 168 - 1.692 1.593 -0.338
ENSG00000116580 E046 15.4256773 0.0018187679 7.816006e-01 8.596885e-01 1 155775170 155775173 4 - 1.218 1.198 -0.073
ENSG00000116580 E047 29.8032046 0.0055058912 8.985521e-01 9.392978e-01 1 155776395 155776481 87 - 1.473 1.486 0.044
ENSG00000116580 E048 66.9286674 0.0136551785 6.715271e-02 1.386230e-01 1 155777622 155777820 199 - 1.888 1.768 -0.404
ENSG00000116580 E049 55.2597460 0.0022417943 9.946141e-04 3.939673e-03 1 155783986 155784089 104 - 1.829 1.663 -0.562
ENSG00000116580 E050 0.7415677 0.2071773167 8.093669e-01 8.789359e-01 1 155784090 155784374 285 - 0.220 0.286 0.497
ENSG00000116580 E051 3.5039823 0.0491913382 1.857190e-01 3.084062e-01 1 155784375 155785333 959 - 0.520 0.758 1.033
ENSG00000116580 E052 41.4728786 0.0005323462 3.883269e-03 1.281617e-02 1 155785334 155785374 41 - 1.701 1.548 -0.521
ENSG00000116580 E053 60.3177582 0.0004361770 1.294442e-04 6.564451e-04 1 155795050 155795151 102 - 1.869 1.699 -0.574
ENSG00000116580 E054 75.7802297 0.0003639887 2.862548e-06 2.151736e-05 1 155804949 155805141 193 - 1.975 1.790 -0.626
ENSG00000116580 E055 59.7965560 0.0105563596 2.125619e-05 1.309742e-04 1 155813634 155813804 171 - 1.912 1.635 -0.934
ENSG00000116580 E056 56.0887672 0.0304422462 4.304347e-03 1.399666e-02 1 155814330 155814449 120 - 1.876 1.623 -0.855
ENSG00000116580 E057 53.7790187 0.0245079574 1.122097e-03 4.377454e-03 1 155815805 155815900 96 - 1.866 1.592 -0.925
ENSG00000116580 E058 1.1749974 0.0169931021 2.410700e-02 6.003286e-02 1 155815901 155816211 311 - 0.520 0.121 -2.852
ENSG00000116580 E059 38.3593085 0.0102790249 1.924567e-04 9.316314e-04 1 155816212 155816262 51 - 1.720 1.452 -0.916
ENSG00000116580 E060 48.3794198 0.0004932308 3.710698e-08 4.102840e-07 1 155820606 155820656 51 - 1.820 1.544 -0.937
ENSG00000116580 E061 53.3257358 0.0030493725 8.014598e-08 8.292417e-07 1 155821474 155821548 75 - 1.867 1.579 -0.978
ENSG00000116580 E062 69.1268605 0.0003896880 2.160186e-17 1.009474e-15 1 155822286 155822446 161 - 2.006 1.643 -1.225
ENSG00000116580 E063 33.9547410 0.0007901636 2.574381e-07 2.414639e-06 1 155822447 155822476 30 - 1.680 1.370 -1.063
ENSG00000116580 E064 34.7956828 0.0017511995 1.711363e-04 8.399505e-04 1 155826837 155826869 33 - 1.659 1.431 -0.779
ENSG00000116580 E065 56.9870511 0.0006090514 1.818419e-10 3.068716e-09 1 155826870 155827028 159 - 1.899 1.600 -1.013
ENSG00000116580 E066 1.2576127 0.0103231174 1.390584e-01 2.467841e-01 1 155831535 155831620 86 - 0.475 0.215 -1.628
ENSG00000116580 E067 1.5929088 0.0089494855 1.860815e-01 3.088403e-01 1 155832832 155832950 119 - 0.520 0.293 -1.266
ENSG00000116580 E068 124.1333134 0.0002568115 2.165223e-18 1.144198e-16 1 155853276 155853806 531 - 2.226 1.950 -0.923
ENSG00000116580 E069 0.5503986 0.0205780117 5.876319e-01 7.108974e-01 1 155853807 155853809 3 - 0.124 0.215 0.959
ENSG00000116580 E070 21.6939359 0.0008753677 5.534790e-03 1.737844e-02 1 155857147 155857158 12 - 1.449 1.247 -0.700
ENSG00000116580 E071 27.9784128 0.0008349251 5.095857e-05 2.866204e-04 1 155857159 155857295 137 - 1.584 1.320 -0.909
ENSG00000116580 E072 1.9293377 0.0077736999 7.074489e-02 1.445783e-01 1 155859304 155859400 97 - 0.599 0.293 -1.628