ENSG00000116406

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000439962 ENSG00000116406 HEK293_OSMI2_2hA HEK293_TMG_2hB EDEM3 protein_coding nonsense_mediated_decay 10.69874 2.848441 15.92448 0.2456665 0.2677087 2.478851 0.4362188 0.9143505 0.00000000 0.3431333 0.00000000 -6.530368 0.14182083 0.30410000 0.0000000000 -0.3041000 2.421710e-09 2.033385e-18 TRUE TRUE
ENST00000466392 ENSG00000116406 HEK293_OSMI2_2hA HEK293_TMG_2hB EDEM3 protein_coding retained_intron 10.69874 2.848441 15.92448 0.2456665 0.2677087 2.478851 0.2675399 0.9039579 0.01128472 0.2244361 0.01128472 -5.424238 0.08520833 0.30750000 0.0007333333 -0.3067667 2.033385e-18 2.033385e-18 FALSE TRUE
ENST00000686225 ENSG00000116406 HEK293_OSMI2_2hA HEK293_TMG_2hB EDEM3 protein_coding protein_coding 10.69874 2.848441 15.92448 0.2456665 0.2677087 2.478851 1.7855548 0.2010136 3.41916000 0.2010136 1.43426079 4.022448 0.14258333 0.08516667 0.2140000000 0.1288333 3.124314e-01 2.033385e-18 FALSE TRUE
ENST00000687113 ENSG00000116406 HEK293_OSMI2_2hA HEK293_TMG_2hB EDEM3 protein_coding protein_coding 10.69874 2.848441 15.92448 0.2456665 0.2677087 2.478851 4.9386986 0.5256086 7.94048538 0.2653602 0.88076883 3.891792 0.36760000 0.19973333 0.4987000000 0.2989667 4.240239e-01 2.033385e-18 FALSE TRUE
MSTRG.2737.18 ENSG00000116406 HEK293_OSMI2_2hA HEK293_TMG_2hB EDEM3 protein_coding   10.69874 2.848441 15.92448 0.2456665 0.2677087 2.478851 1.3560923 0.0000000 2.24510148 0.0000000 0.30012828 7.817049 0.07475417 0.00000000 0.1404000000 0.1404000 7.739010e-09 2.033385e-18 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116406 E001 0.1482932 0.0414427549 5.375580e-02   1 184690237 184690492 256 - 0.000 0.285 13.135
ENSG00000116406 E002 0.1482932 0.0414427549 5.375580e-02   1 184690493 184690502 10 - 0.000 0.285 15.691
ENSG00000116406 E003 0.4782907 0.0215457808 9.451707e-04 3.772220e-03 1 184690503 184690517 15 - 0.000 0.578 17.488
ENSG00000116406 E004 0.4782907 0.0215457808 9.451707e-04 3.772220e-03 1 184690518 184690518 1 - 0.000 0.578 17.488
ENSG00000116406 E005 0.6298062 0.0182344037 5.235677e-03 1.657310e-02 1 184690519 184690539 21 - 0.047 0.578 4.614
ENSG00000116406 E006 3.7371721 0.0757590487 7.281952e-04 3.000313e-03 1 184690540 184690570 31 - 0.374 1.077 3.000
ENSG00000116406 E007 7.5130644 0.0538401928 3.499410e-07 3.193260e-06 1 184690571 184690586 16 - 0.531 1.394 3.311
ENSG00000116406 E008 46.0168797 0.0566005326 3.536244e-06 2.605619e-05 1 184690587 184690668 82 - 1.316 2.039 2.459
ENSG00000116406 E009 73.1782801 0.0379686138 7.057413e-08 7.377805e-07 1 184690669 184690820 152 - 1.533 2.205 2.265
ENSG00000116406 E010 44.4350940 0.0351663786 8.470625e-07 7.146486e-06 1 184690821 184690851 31 - 1.340 1.967 2.134
ENSG00000116406 E011 123.1759239 0.0166330521 4.264348e-15 1.481511e-13 1 184690852 184691353 502 - 1.766 2.404 2.139
ENSG00000116406 E012 18.2994136 0.0133743680 8.034251e-08 8.311389e-07 1 184691354 184691371 18 - 0.974 1.601 2.208
ENSG00000116406 E013 91.4512855 0.0092790966 1.264348e-08 1.529547e-07 1 184691372 184691730 359 - 1.703 2.149 1.498
ENSG00000116406 E014 98.1164476 0.0065499602 7.235532e-03 2.183557e-02 1 184691731 184691983 253 - 1.782 2.031 0.839
ENSG00000116406 E015 44.6715115 0.0025523997 4.310230e-01 5.736205e-01 1 184691984 184692011 28 - 1.484 1.514 0.105
ENSG00000116406 E016 79.9220304 0.0003431732 2.096868e-01 3.381796e-01 1 184692012 184692145 134 - 1.711 1.872 0.545
ENSG00000116406 E017 186.5171874 0.0006333246 8.724321e-04 3.517786e-03 1 184692146 184692912 767 - 2.066 2.277 0.706
ENSG00000116406 E018 120.4921419 0.0003052385 3.909915e-01 5.349407e-01 1 184692913 184693365 453 - 1.904 1.960 0.189
ENSG00000116406 E019 29.0978175 0.0418963280 7.805676e-01 8.590011e-01 1 184693366 184693373 8 - 1.303 1.369 0.228
ENSG00000116406 E020 52.3507096 0.0004596482 9.270039e-01 9.580627e-01 1 184693374 184693432 59 - 1.542 1.642 0.341
ENSG00000116406 E021 159.2992870 0.0026113358 9.550757e-03 2.766059e-02 1 184693433 184694043 611 - 2.034 2.004 -0.100
ENSG00000116406 E022 124.4097194 0.0011272774 2.343496e-06 1.795719e-05 1 184694044 184694472 429 - 1.942 1.789 -0.517
ENSG00000116406 E023 0.1472490 0.0440309801 8.427577e-01   1 184701497 184701529 33 - 0.047 0.000 -11.962
ENSG00000116406 E024 0.1472490 0.0440309801 8.427577e-01   1 184701530 184701541 12 - 0.047 0.000 -11.962
ENSG00000116406 E025 0.1472490 0.0440309801 8.427577e-01   1 184701542 184701544 3 - 0.047 0.000 -11.962
ENSG00000116406 E026 76.1897494 0.0159449543 9.476591e-04 3.780240e-03 1 184702811 184702996 186 - 1.738 1.528 -0.716
ENSG00000116406 E027 0.6955713 0.0168440716 7.710498e-02 1.548475e-01 1 184702997 184703659 663 - 0.089 0.457 3.034
ENSG00000116406 E028 76.5784318 0.0025542487 3.149497e-06 2.344727e-05 1 184706643 184706808 166 - 1.743 1.501 -0.824
ENSG00000116406 E029 40.6795286 0.0005506339 3.292643e-06 2.443422e-05 1 184708153 184708210 58 - 1.484 1.117 -1.284
ENSG00000116406 E030 63.9385959 0.0004045883 3.288708e-08 3.674211e-07 1 184708211 184708344 134 - 1.672 1.332 -1.166
ENSG00000116406 E031 40.1228535 0.0162347580 5.116380e-04 2.203366e-03 1 184710394 184710450 57 - 1.473 1.150 -1.130
ENSG00000116406 E032 56.1710275 0.0069057312 1.005861e-04 5.245898e-04 1 184710451 184710547 97 - 1.612 1.351 -0.897
ENSG00000116406 E033 5.9508109 0.0026593895 1.687370e-02 4.465498e-02 1 184710548 184710550 3 - 0.735 0.286 -2.253
ENSG00000116406 E034 77.0389871 0.0005128084 4.837088e-08 5.232225e-07 1 184711723 184711877 155 - 1.748 1.461 -0.977
ENSG00000116406 E035 0.7415557 0.1338270142 6.752588e-01 7.805920e-01 1 184711878 184712432 555 - 0.163 0.284 1.020
ENSG00000116406 E036 58.8752100 0.0995040272 1.056009e-02 3.011239e-02 1 184712433 184712598 166 - 1.637 1.306 -1.140
ENSG00000116406 E037 10.1962032 0.0105090656 7.051415e-01 8.035600e-01 1 184713523 184716887 3365 - 0.874 1.013 0.518
ENSG00000116406 E038 43.5828017 0.0247940147 5.850600e-02 1.240774e-01 1 184716888 184717012 125 - 1.492 1.371 -0.418
ENSG00000116406 E039 39.4832999 0.0005707958 2.033006e-03 7.328874e-03 1 184717540 184717623 84 - 1.457 1.272 -0.645
ENSG00000116406 E040 0.1472490 0.0440309801 8.427577e-01   1 184718838 184719161 324 - 0.047 0.000 -11.962
ENSG00000116406 E041 50.3176323 0.0004720474 3.853667e-05 2.230093e-04 1 184719162 184719245 84 - 1.564 1.313 -0.865
ENSG00000116406 E042 0.6017953 0.1417161455 8.466748e-01 9.047017e-01 1 184719246 184719442 197 - 0.163 0.000 -13.679
ENSG00000116406 E043 60.7132269 0.0004781603 9.143043e-08 9.347664e-07 1 184719443 184719568 126 - 1.649 1.313 -1.157
ENSG00000116406 E044 0.1451727 0.0435256641 8.414010e-01   1 184719569 184720509 941 - 0.047 0.000 -11.963
ENSG00000116406 E045 0.5848434 0.0274316385 7.884446e-01 8.645826e-01 1 184720510 184721288 779 - 0.163 0.000 -13.937
ENSG00000116406 E046 54.3989646 0.0004493752 3.686765e-06 2.706213e-05 1 184721289 184721386 98 - 1.600 1.313 -0.989
ENSG00000116406 E047 50.6901629 0.0012150125 7.919782e-07 6.723333e-06 1 184723751 184723856 106 - 1.574 1.226 -1.206
ENSG00000116406 E048 0.8147197 0.0149243776 1.536374e-02 4.131287e-02 1 184725055 184726254 1200 - 0.089 0.579 3.616
ENSG00000116406 E049 57.0959594 0.0028133504 1.119811e-07 1.127590e-06 1 184726255 184726389 135 - 1.627 1.249 -1.305
ENSG00000116406 E050 0.1472490 0.0440309801 8.427577e-01   1 184732783 184732836 54 - 0.047 0.000 -11.962
ENSG00000116406 E051 64.3972722 0.0025837971 3.330643e-09 4.481076e-08 1 184732837 184732990 154 - 1.682 1.271 -1.414
ENSG00000116406 E052 0.4449813 0.0213894901 3.404324e-01 4.843893e-01 1 184732991 184734339 1349 - 0.089 0.285 2.030
ENSG00000116406 E053 43.5588586 0.0046510868 9.528723e-05 4.998859e-04 1 184734531 184734643 113 - 1.510 1.225 -0.991
ENSG00000116406 E054 0.4396707 0.0327270956 1.000000e+00 1.000000e+00 1 184736950 184737024 75 - 0.128 0.000 -13.532
ENSG00000116406 E055 28.2850077 0.0011266339 1.009171e-04 5.261716e-04 1 184737025 184737064 40 - 1.334 0.972 -1.298
ENSG00000116406 E056 43.0654279 0.0004961683 4.821005e-05 2.727239e-04 1 184737611 184737711 101 - 1.503 1.226 -0.963
ENSG00000116406 E057 0.1472490 0.0440309801 8.427577e-01   1 184737712 184737736 25 - 0.047 0.000 -11.962
ENSG00000116406 E058 0.9556260 0.0159626497 3.269742e-02 7.719684e-02 1 184744635 184746749 2115 - 0.128 0.579 3.031
ENSG00000116406 E059 24.9832754 0.0036724394 4.099650e-04 1.812542e-03 1 184749547 184749592 46 - 1.281 0.927 -1.282
ENSG00000116406 E060 57.3787107 0.0028009545 1.091792e-08 1.336586e-07 1 184754489 184754907 419 - 1.631 1.201 -1.487