ENSG00000116237

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343813 ENSG00000116237 HEK293_OSMI2_2hA HEK293_TMG_2hB ICMT protein_coding protein_coding 90.31842 87.97666 94.13486 11.46878 2.178553 0.09759762 46.975320 47.7862176 46.376134 5.65948780 0.4221348 -0.04320283 0.53125833 0.545166667 0.49300000 -0.052166667 7.473258e-02 6.484463e-28 FALSE TRUE
ENST00000489498 ENSG00000116237 HEK293_OSMI2_2hA HEK293_TMG_2hB ICMT protein_coding nonsense_mediated_decay 90.31842 87.97666 94.13486 11.46878 2.178553 0.09759762 14.525999 6.2978836 25.371765 3.59780279 1.1681449 2.00856442 0.15577083 0.078500000 0.27040000 0.191900000 5.170498e-01 6.484463e-28 FALSE TRUE
ENST00000495791 ENSG00000116237 HEK293_OSMI2_2hA HEK293_TMG_2hB ICMT protein_coding processed_transcript 90.31842 87.97666 94.13486 11.46878 2.178553 0.09759762 12.071191 17.3832719 2.545798 5.28431094 2.5457977 -2.76668377 0.13300833 0.190566667 0.02603333 -0.164533333 5.728160e-02 6.484463e-28   FALSE
MSTRG.192.6 ENSG00000116237 HEK293_OSMI2_2hA HEK293_TMG_2hB ICMT protein_coding   90.31842 87.97666 94.13486 11.46878 2.178553 0.09759762 8.327446 9.8651810 11.214210 0.83005755 0.5289753 0.18473487 0.09412917 0.114900000 0.11903333 0.004133333 9.250945e-01 6.484463e-28 TRUE FALSE
MSTRG.192.9 ENSG00000116237 HEK293_OSMI2_2hA HEK293_TMG_2hB ICMT protein_coding   90.31842 87.97666 94.13486 11.46878 2.178553 0.09759762 4.806993 0.1468454 5.958669 0.08547358 0.4492551 5.24999394 0.04712500 0.001466667 0.06313333 0.061666667 6.484463e-28 6.484463e-28 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116237 E001 18.750615 0.0165820865 9.527936e-02 1.832955e-01 1 6219236 6221118 1883 - 1.191 1.359 0.586
ENSG00000116237 E002 2.577488 0.0111043689 7.290415e-02 1.481711e-01 1 6221119 6221192 74 - 0.372 0.676 1.467
ENSG00000116237 E003 2.946106 0.0095862792 1.152983e-04 5.923022e-04 1 6221193 6221196 4 - 0.127 0.799 3.966
ENSG00000116237 E004 85.505837 0.0052071937 1.765075e-24 1.839319e-22 1 6221197 6221313 117 - 1.516 2.114 2.020
ENSG00000116237 E005 1309.199529 0.0031304310 5.798392e-17 2.565362e-15 1 6221314 6221897 584 - 2.972 3.199 0.755
ENSG00000116237 E006 542.644634 0.0001396222 3.491054e-15 1.229380e-13 1 6221898 6222160 263 - 2.661 2.792 0.437
ENSG00000116237 E007 1660.472312 0.0003448835 4.305283e-05 2.463597e-04 1 6222161 6223437 1277 - 3.193 3.242 0.162
ENSG00000116237 E008 272.170501 0.0001615888 1.935734e-04 9.363195e-04 1 6223438 6223490 53 - 2.389 2.477 0.294
ENSG00000116237 E009 3325.434970 0.0005241188 1.073118e-07 1.084073e-06 1 6223491 6224598 1108 - 3.491 3.542 0.170
ENSG00000116237 E010 1993.670681 0.0018287269 4.826468e-06 3.449503e-05 1 6224599 6225262 664 - 3.348 3.254 -0.313
ENSG00000116237 E011 1029.018319 0.0015221814 4.244154e-10 6.734022e-09 1 6231902 6232119 218 - 3.081 2.948 -0.444
ENSG00000116237 E012 640.339910 0.0008813803 1.848276e-17 8.755949e-16 1 6233474 6233643 170 - 2.893 2.727 -0.553
ENSG00000116237 E013 60.195490 0.0058817279 5.794149e-02 1.231071e-01 1 6234405 6234511 107 - 1.845 1.735 -0.373
ENSG00000116237 E014 367.878981 0.0022386515 3.720786e-18 1.909758e-16 1 6234886 6234970 85 - 2.692 2.435 -0.855
ENSG00000116237 E015 147.576391 0.0024913543 4.349937e-16 1.721501e-14 1 6234971 6234974 4 - 2.318 2.009 -1.035
ENSG00000116237 E016 2.259248 0.0099407306 3.410260e-01 4.849529e-01 1 6235500 6235716 217 - 0.607 0.458 -0.702
ENSG00000116237 E017 242.855619 0.0057885949 1.300205e-19 7.935563e-18 1 6235717 6236019 303 - 2.567 2.162 -1.352