ENSG00000116213

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000270708 ENSG00000116213 HEK293_OSMI2_2hA HEK293_TMG_2hB WRAP73 protein_coding protein_coding 51.40494 71.12535 38.5482 4.507105 0.7109258 -0.8835289 10.627164 13.3483623 7.373889 0.5634467 0.7599601 -0.8552905 0.21052917 0.188333333 0.19173333 0.00340000 1.000000e+00 2.51351e-12 FALSE TRUE
ENST00000378322 ENSG00000116213 HEK293_OSMI2_2hA HEK293_TMG_2hB WRAP73 protein_coding protein_coding 51.40494 71.12535 38.5482 4.507105 0.7109258 -0.8835289 22.061433 34.6102975 13.585122 2.4101898 0.3620009 -1.3485291 0.41700417 0.486233333 0.35230000 -0.13393333 2.513510e-12 2.51351e-12 FALSE TRUE
ENST00000465916 ENSG00000116213 HEK293_OSMI2_2hA HEK293_TMG_2hB WRAP73 protein_coding protein_coding 51.40494 71.12535 38.5482 4.507105 0.7109258 -0.8835289 1.573000 0.3961411 3.443213 0.3961411 0.7662864 3.0878866 0.03503333 0.005033333 0.08930000 0.08426667 2.217587e-02 2.51351e-12 FALSE FALSE
ENST00000469643 ENSG00000116213 HEK293_OSMI2_2hA HEK293_TMG_2hB WRAP73 protein_coding retained_intron 51.40494 71.12535 38.5482 4.507105 0.7109258 -0.8835289 1.646548 0.5212085 2.405202 0.2610732 0.2731315 2.1847935 0.03820417 0.007766667 0.06223333 0.05446667 8.202960e-02 2.51351e-12 FALSE TRUE
MSTRG.174.3 ENSG00000116213 HEK293_OSMI2_2hA HEK293_TMG_2hB WRAP73 protein_coding   51.40494 71.12535 38.5482 4.507105 0.7109258 -0.8835289 12.393750 19.5986584 8.838733 1.2591209 0.5253790 -1.1479480 0.23491667 0.275533333 0.22896667 -0.04656667 8.522998e-02 2.51351e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116213 E001 0.772888 0.0162888862 1.807073e-01 3.020787e-01 1 3630767 3630769 3 - 0.000 0.271 10.059
ENSG00000116213 E002 6.997653 0.0023811480 1.341379e-01 2.399085e-01 1 3630770 3630788 19 - 0.691 0.899 0.825
ENSG00000116213 E003 593.209340 0.0001796373 1.254278e-11 2.569967e-10 1 3630789 3631117 329 - 2.629 2.747 0.393
ENSG00000116213 E004 408.819873 0.0001753168 5.685941e-13 1.450558e-11 1 3631118 3631465 348 - 2.440 2.592 0.505
ENSG00000116213 E005 604.440167 0.0019099483 9.605922e-06 6.412535e-05 1 3631466 3631657 192 - 2.639 2.757 0.393
ENSG00000116213 E006 39.778172 0.0007310446 3.369359e-01 4.807972e-01 1 3631886 3632212 327 - 1.593 1.536 -0.193
ENSG00000116213 E007 528.218537 0.0006137589 6.284806e-05 3.454027e-04 1 3632213 3632338 126 - 2.605 2.690 0.281
ENSG00000116213 E008 36.413454 0.0005964301 1.436260e-21 1.091875e-19 1 3632339 3632765 427 - 1.845 1.297 -1.872
ENSG00000116213 E009 31.385005 0.0016248121 6.447195e-18 3.232932e-16 1 3632766 3633309 544 - 1.776 1.226 -1.891
ENSG00000116213 E010 7.125961 0.0541733324 6.758053e-04 2.810619e-03 1 3633310 3633397 88 - 1.181 0.650 -2.030
ENSG00000116213 E011 433.342313 0.0002086214 1.794729e-02 4.702125e-02 1 3633398 3633503 106 - 2.546 2.595 0.161
ENSG00000116213 E012 43.824602 0.0031844800 4.939714e-34 1.128847e-31 1 3633504 3634915 1412 - 1.984 1.264 -2.457
ENSG00000116213 E013 8.443668 0.0022324215 3.214414e-14 9.818213e-13 1 3634916 3634996 81 - 1.353 0.501 -3.312
ENSG00000116213 E014 237.180225 0.0002203973 3.886853e-01 5.327627e-01 1 3634997 3635013 17 - 2.302 2.326 0.081
ENSG00000116213 E015 353.176467 0.0002106751 4.407090e-01 5.823829e-01 1 3635014 3635074 61 - 2.478 2.497 0.062
ENSG00000116213 E016 12.286650 0.0016608962 3.896585e-04 1.734688e-03 1 3635075 3635159 85 - 1.292 0.955 -1.214
ENSG00000116213 E017 331.756272 0.0006845891 5.334286e-01 6.656217e-01 1 3635160 3635271 112 - 2.475 2.462 -0.041
ENSG00000116213 E018 179.424815 0.0002498077 6.726674e-01 7.785465e-01 1 3635272 3635294 23 - 2.207 2.196 -0.036
ENSG00000116213 E019 71.475506 0.0004335673 4.788988e-58 4.559092e-55 1 3635295 3635943 649 - 2.179 1.502 -2.287
ENSG00000116213 E020 427.543194 0.0001684602 9.875537e-01 9.962926e-01 1 3635944 3636030 87 - 2.573 2.575 0.008
ENSG00000116213 E021 28.680972 0.0008016468 1.382031e-20 9.475994e-19 1 3636031 3636994 964 - 1.765 1.166 -2.069
ENSG00000116213 E022 454.846295 0.0001952855 7.314363e-01 8.230874e-01 1 3636995 3637098 104 - 2.604 2.600 -0.014
ENSG00000116213 E023 402.223264 0.0003111921 3.183299e-01 4.613033e-01 1 3638750 3638822 73 - 2.562 2.544 -0.060
ENSG00000116213 E024 3.583579 0.0046827589 3.128119e-01 4.553446e-01 1 3638823 3639625 803 - 0.733 0.581 -0.646
ENSG00000116213 E025 482.531886 0.0012456377 6.641436e-01 7.720062e-01 1 3646666 3646782 117 - 2.634 2.627 -0.021
ENSG00000116213 E026 12.509146 0.0141044783 6.913859e-01 7.928824e-01 1 3647246 3647407 162 - 1.052 1.101 0.178
ENSG00000116213 E027 524.484531 0.0007128026 6.700612e-02 1.383931e-01 1 3647408 3647560 153 - 2.690 2.656 -0.113
ENSG00000116213 E028 318.748311 0.0004601807 2.529708e-04 1.187692e-03 1 3649931 3650281 351 - 2.506 2.424 -0.273
ENSG00000116213 E029 2.144423 0.4173267526 9.097834e-01 9.466558e-01 1 3652713 3652761 49 - 0.393 0.463 0.372