ENSG00000116209

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371341 ENSG00000116209 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM59 protein_coding protein_coding 80.74998 46.53764 115.905 9.264225 2.013601 1.316288 29.565663 18.151918 42.46858 3.630996 2.315683 1.2258191 0.3732458 0.3909000 0.3660000 -0.02490000 8.163735e-01 5.710377e-05 FALSE  
ENST00000371348 ENSG00000116209 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM59 protein_coding protein_coding 80.74998 46.53764 115.905 9.264225 2.013601 1.316288 9.191807 8.650639 12.69748 2.176006 0.438001 0.5531324 0.1238083 0.1826333 0.1095667 -0.07306667 5.710377e-05 5.710377e-05 FALSE  
MSTRG.1234.4 ENSG00000116209 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM59 protein_coding   80.74998 46.53764 115.905 9.264225 2.013601 1.316288 37.021339 17.674000 54.33267 3.318286 1.501923 1.6196408 0.4460542 0.3827333 0.4687333 0.08600000 1.148116e-01 5.710377e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116209 E001 162.0074441 0.0002604698 4.187163e-20 2.691705e-18 1 54026681 54031662 4982 - 2.292 1.998 -0.985
ENSG00000116209 E002 4.6407668 0.0161534953 6.098928e-02 1.282991e-01 1 54031663 54031675 13 - 0.829 0.519 -1.317
ENSG00000116209 E003 250.5110047 0.0011830843 4.820317e-10 7.565822e-09 1 54031676 54031876 201 - 2.323 2.494 0.570
ENSG00000116209 E004 169.2812143 0.0002309813 2.136256e-15 7.727847e-14 1 54031877 54031897 21 - 2.133 2.350 0.724
ENSG00000116209 E005 229.0232802 0.0005183919 7.005410e-16 2.701861e-14 1 54031898 54031965 68 - 2.269 2.472 0.677
ENSG00000116209 E006 166.0405259 0.0002523960 6.446702e-17 2.840913e-15 1 54031966 54032018 53 - 2.117 2.348 0.773
ENSG00000116209 E007 730.3597950 0.0003494813 5.527553e-13 1.412434e-11 1 54032019 54032305 287 - 2.815 2.920 0.350
ENSG00000116209 E008 0.1451727 0.0440818679 1.000000e+00   1 54036599 54036601 3 - 0.090 0.000 -9.482
ENSG00000116209 E009 0.1451727 0.0440818679 1.000000e+00   1 54036602 54036609 8 - 0.090 0.000 -9.482
ENSG00000116209 E010 697.2893397 0.0001285857 4.980738e-02 1.088171e-01 1 54036610 54036718 109 - 2.828 2.852 0.081
ENSG00000116209 E011 0.9630129 0.0128454403 1.006014e-01 1.913724e-01 1 54036719 54036802 84 - 0.164 0.453 2.000
ENSG00000116209 E012 655.5442885 0.0002153280 9.432698e-01 9.684095e-01 1 54040756 54040837 82 - 2.811 2.808 -0.009
ENSG00000116209 E013 119.0061847 0.0003167477 2.086399e-04 1.000891e-03 1 54040838 54040840 3 - 2.115 1.981 -0.447
ENSG00000116209 E014 684.7656858 0.0000933095 3.996144e-02 9.096297e-02 1 54041724 54041805 82 - 2.840 2.809 -0.104
ENSG00000116209 E015 895.5704052 0.0001023010 3.805061e-07 3.445451e-06 1 54043373 54043525 153 - 2.968 2.903 -0.218
ENSG00000116209 E016 4.2187774 0.0038610194 3.485465e-01 4.927841e-01 1 54043526 54044942 1417 - 0.766 0.625 -0.584
ENSG00000116209 E017 1.1102750 0.0151813285 2.025249e-01 3.293703e-01 1 54045486 54045691 206 - 0.228 0.453 1.415
ENSG00000116209 E018 592.8144203 0.0001183753 2.759561e-08 3.129545e-07 1 54045692 54045786 95 - 2.796 2.708 -0.296
ENSG00000116209 E019 607.8253369 0.0025223615 1.545199e-03 5.781924e-03 1 54047267 54047372 106 - 2.809 2.704 -0.349
ENSG00000116209 E020 7.4874747 0.2303960427 2.434652e-01 3.782495e-01 1 54047373 54048013 641 - 0.989 0.731 -0.999
ENSG00000116209 E021 1.8779436 0.0099309514 2.078321e-01 3.358798e-01 1 54048650 54048682 33 - 0.518 0.284 -1.318
ENSG00000116209 E022 494.4448128 0.0007579178 4.246712e-07 3.810370e-06 1 54053000 54053355 356 - 2.724 2.611 -0.376
ENSG00000116209 E023 76.6625812 0.0003593748 5.591836e-05 3.112515e-04 1 54053356 54053504 149 - 1.818 1.981 0.547