ENSG00000116205

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000234827 ENSG00000116205 HEK293_OSMI2_2hA HEK293_TMG_2hB TCEANC2 protein_coding protein_coding 9.881967 8.172943 10.20529 0.3770678 0.1240275 0.3200382 3.304881 2.287304 3.8509821 0.1216116 0.1849646 0.7490262 0.3430625 0.2797333 0.37706667 0.09733333 0.03661236 0.03661236 FALSE  
MSTRG.1236.4 ENSG00000116205 HEK293_OSMI2_2hA HEK293_TMG_2hB TCEANC2 protein_coding   9.881967 8.172943 10.20529 0.3770678 0.1240275 0.3200382 2.809250 3.498404 0.6107088 0.5275067 0.6107088 -2.4988264 0.2851125 0.4316667 0.06086667 -0.37080000 0.05265809 0.03661236 TRUE  
MSTRG.1236.5 ENSG00000116205 HEK293_OSMI2_2hA HEK293_TMG_2hB TCEANC2 protein_coding   9.881967 8.172943 10.20529 0.3770678 0.1240275 0.3200382 2.024030 1.013782 4.0948488 0.5655372 0.8166972 2.0034207 0.1949875 0.1206000 0.40013333 0.27953333 0.31872439 0.03661236 TRUE  
MSTRG.1236.7 ENSG00000116205 HEK293_OSMI2_2hA HEK293_TMG_2hB TCEANC2 protein_coding   9.881967 8.172943 10.20529 0.3770678 0.1240275 0.3200382 1.332702 1.060365 1.4581725 0.1064315 0.1999120 0.4559184 0.1327958 0.1296667 0.14330000 0.01363333 0.89506310 0.03661236 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116205 E001 1.5456913 0.0091907497 3.340137e-01 4.777746e-01 1 54053584 54053586 3 + 0.339 0.498 0.865
ENSG00000116205 E002 1.8610405 0.5711041701 9.032953e-01 9.424671e-01 1 54053587 54053605 19 + 0.338 0.550 1.114
ENSG00000116205 E003 2.4522241 0.1510484618 1.300312e-01 2.342120e-01 1 54053606 54053607 2 + 0.338 0.667 1.630
ENSG00000116205 E004 2.9400667 0.0117035979 3.338509e-02 7.854758e-02 1 54053608 54053614 7 + 0.394 0.725 1.547
ENSG00000116205 E005 36.8552850 0.0012931332 5.504513e-01 6.800839e-01 1 54053615 54053758 144 + 1.602 1.554 -0.162
ENSG00000116205 E006 0.0000000       1 54054079 54054133 55 +      
ENSG00000116205 E007 0.1817044 0.0402818096 3.907593e-01   1 54054134 54054380 247 + 0.000 0.133 9.609
ENSG00000116205 E008 58.3419609 0.0048874076 4.645478e-01 6.042624e-01 1 54054381 54054524 144 + 1.801 1.749 -0.179
ENSG00000116205 E009 40.9376739 0.0006387711 7.516222e-02 1.517995e-01 1 54068756 54068897 142 + 1.672 1.563 -0.374
ENSG00000116205 E010 115.8210672 0.0002787708 3.175360e-01 4.604311e-01 1 54088597 54088790 194 + 2.061 2.081 0.065
ENSG00000116205 E011 263.7436997 0.0003370357 1.824726e-16 7.600898e-15 1 54096285 54096844 560 + 2.341 2.500 0.532
ENSG00000116205 E012 284.6945771 0.0002913164 5.742924e-01 7.001382e-01 1 54096845 54098205 1361 + 2.472 2.448 -0.078
ENSG00000116205 E013 35.7048131 0.0058499494 5.310915e-03 1.677846e-02 1 54098206 54098302 97 + 1.658 1.455 -0.693
ENSG00000116205 E014 456.1397437 0.0021143994 1.650144e-05 1.043162e-04 1 54098303 54104294 5992 + 2.711 2.605 -0.354
ENSG00000116205 E015 20.5968388 0.0009228274 1.746630e-01 2.942613e-01 1 54104295 54104564 270 + 1.391 1.277 -0.396
ENSG00000116205 E016 79.7322747 0.0048383497 2.060737e-02 5.276252e-02 1 54104565 54106082 1518 + 1.854 1.954 0.336
ENSG00000116205 E017 7.2134248 0.0024168109 5.528249e-02 1.184807e-01 1 54107094 54107247 154 + 1.019 0.780 -0.911
ENSG00000116205 E018 12.6907562 0.0345264880 4.762636e-02 1.049550e-01 1 54108176 54108327 152 + 1.007 1.252 0.883
ENSG00000116205 E019 14.7549681 0.0175596360 2.416115e-01 3.760783e-01 1 54111052 54112519 1468 + 1.258 1.121 -0.487