ENSG00000116191

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367632 ENSG00000116191 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGPS2 protein_coding protein_coding 6.595585 1.511255 12.12343 0.09762551 0.6919505 2.995653 1.9108949 0.00000000 3.66944190 0.00000000 0.45297897 8.523343 0.1573750 0.00000000 0.300933333 0.30093333 4.443011e-12 2.254502e-19 FALSE FALSE
ENST00000367634 ENSG00000116191 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGPS2 protein_coding protein_coding 6.595585 1.511255 12.12343 0.09762551 0.6919505 2.995653 3.4588505 0.71289622 6.90428718 0.07678831 0.26554772 3.257720 0.5425167 0.47613333 0.572000000 0.09586667 4.550354e-01 2.254502e-19 FALSE TRUE
ENST00000367635 ENSG00000116191 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGPS2 protein_coding protein_coding 6.595585 1.511255 12.12343 0.09762551 0.6919505 2.995653 0.4846047 0.01734528 0.84996769 0.01734528 0.14314091 4.974919 0.0561250 0.01036667 0.070000000 0.05963333 4.740793e-02 2.254502e-19 FALSE TRUE
ENST00000478871 ENSG00000116191 HEK293_OSMI2_2hA HEK293_TMG_2hB RALGPS2 protein_coding retained_intron 6.595585 1.511255 12.12343 0.09762551 0.6919505 2.995653 0.2610443 0.76383497 0.06570427 0.11186960 0.03531285 -3.353579 0.1798167 0.50166667 0.005566667 -0.49610000 2.254502e-19 2.254502e-19 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116191 E001 1.2359696 0.4216627186 8.998171e-01 9.400806e-01 1 178725165 178725218 54 + 0.285 0.258 -0.189
ENSG00000116191 E002 1.5326577 0.3609804244 9.373039e-01 9.646108e-01 1 178725219 178725243 25 + 0.340 0.258 -0.550
ENSG00000116191 E003 18.0224315 0.0077583611 7.168092e-02 1.461459e-01 1 178725244 178725395 152 + 1.185 0.958 -0.822
ENSG00000116191 E004 14.6887785 0.0068856924 6.678244e-01 7.749772e-01 1 178725396 178725419 24 + 1.080 1.030 -0.181
ENSG00000116191 E005 32.3024016 0.0006305009 5.537900e-01 6.828818e-01 1 178776682 178776821 140 + 1.402 1.358 -0.152
ENSG00000116191 E006 28.0563271 0.0006868800 3.853112e-01 5.295070e-01 1 178784418 178784522 105 + 1.347 1.274 -0.255
ENSG00000116191 E007 22.6017962 0.0008308235 3.256486e-01 4.690923e-01 1 178785557 178785607 51 + 1.262 1.168 -0.332
ENSG00000116191 E008 24.5805560 0.0008021082 1.029945e-01 1.950361e-01 1 178808045 178808128 84 + 1.304 1.144 -0.565
ENSG00000116191 E009 24.5836295 0.0008496395 7.114854e-03 2.152281e-02 1 178811315 178811404 90 + 1.318 1.029 -1.028
ENSG00000116191 E010 22.9724987 0.0008823123 9.605608e-05 5.035429e-04 1 178821612 178821704 93 + 1.307 0.823 -1.768
ENSG00000116191 E011 30.2938883 0.0007058237 3.199653e-03 1.085538e-02 1 178833424 178833550 127 + 1.404 1.118 -1.007
ENSG00000116191 E012 37.8463632 0.0021484406 1.117822e-02 3.159396e-02 1 178877498 178877635 138 + 1.491 1.274 -0.755
ENSG00000116191 E013 23.0815465 0.0042876722 2.839001e-01 4.240973e-01 1 178878902 178878944 43 + 1.275 1.168 -0.376
ENSG00000116191 E014 22.7357535 0.0046704690 3.341683e-01 4.779235e-01 1 178878945 178878992 48 + 1.265 1.169 -0.342
ENSG00000116191 E015 0.1515154 0.0428304128 9.465688e-01   1 178878993 178879788 796 + 0.053 0.000 -7.997
ENSG00000116191 E016 22.8611414 0.0046396365 9.682942e-01 9.842006e-01 1 178883466 178883533 68 + 1.253 1.255 0.006
ENSG00000116191 E017 35.4764658 0.0006294718 8.430101e-04 3.412297e-03 1 178885076 178885211 136 + 1.473 1.168 -1.063
ENSG00000116191 E018 2.8109856 0.0054889362 3.180820e-02 7.548595e-02 1 178885212 178885621 410 + 0.543 0.000 -12.324
ENSG00000116191 E019 15.8207218 0.0128358920 2.029672e-04 9.764970e-04 1 178885969 178885976 8 + 1.162 0.534 -2.480
ENSG00000116191 E020 33.0742496 0.0006339009 2.628692e-06 1.993187e-05 1 178885977 178886078 102 + 1.457 0.958 -1.775
ENSG00000116191 E021 20.4378888 0.0009134616 1.793465e-01 3.002930e-01 1 178886079 178886120 42 + 1.230 1.090 -0.499
ENSG00000116191 E022 23.2136964 0.0008229665 1.636879e-01 2.799384e-01 1 178889642 178889696 55 + 1.281 1.144 -0.484
ENSG00000116191 E023 2.8034970 0.0053680050 2.147305e-01 3.441134e-01 1 178892230 178892307 78 + 0.526 0.257 -1.546
ENSG00000116191 E024 0.2987644 0.0272244772 1.000000e+00   1 178893838 178893918 81 + 0.101 0.000 -9.114
ENSG00000116191 E025 36.0180404 0.0005703343 3.002820e-03 1.027333e-02 1 178893919 178894024 106 + 1.475 1.214 -0.909
ENSG00000116191 E026 0.3729606 0.0305102122 1.898257e-01 3.135438e-01 1 178894025 178894325 301 + 0.053 0.258 2.628
ENSG00000116191 E027 40.9277916 0.0004992057 1.824728e-04 8.885244e-04 1 178897664 178897756 93 + 1.535 1.214 -1.116
ENSG00000116191 E028 49.8353670 0.0005057056 2.041109e-02 5.235477e-02 1 178902106 178902211 106 + 1.604 1.442 -0.555
ENSG00000116191 E029 44.1942512 0.0027513088 3.679343e-01 5.123264e-01 1 178906776 178906867 92 + 1.540 1.478 -0.212
ENSG00000116191 E030 619.4923155 0.0002716828 1.341436e-36 3.693764e-34 1 178916330 178921842 5513 + 2.631 2.798 0.557