ENSG00000116151

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378529 ENSG00000116151 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN1 protein_coding protein_coding 11.02455 15.91949 9.092227 1.072451 0.3440885 -0.8074085 1.8818420 2.1564788 1.3584382 0.29528874 0.05762020 -0.66282185 0.17432500 0.13563333 0.15026667 0.01463333 8.294782e-01 9.429651e-05 FALSE  
ENST00000378531 ENSG00000116151 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN1 protein_coding protein_coding 11.02455 15.91949 9.092227 1.072451 0.3440885 -0.8074085 0.3908263 0.3840041 0.7415944 0.06721116 0.06317143 0.93174359 0.03800000 0.02380000 0.08230000 0.05850000 9.429651e-05 9.429651e-05 FALSE  
ENST00000469374 ENSG00000116151 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN1 protein_coding retained_intron 11.02455 15.91949 9.092227 1.072451 0.3440885 -0.8074085 0.5146031 0.6081816 0.5324032 0.08519188 0.15647655 -0.18866508 0.05210833 0.03823333 0.05883333 0.02060000 6.621959e-01 9.429651e-05    
ENST00000475812 ENSG00000116151 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN1 protein_coding retained_intron 11.02455 15.91949 9.092227 1.072451 0.3440885 -0.8074085 0.7581300 1.1268453 0.7889235 0.50070094 0.48169700 -0.50890669 0.06256667 0.07196667 0.08313333 0.01116667 9.539526e-01 9.429651e-05 FALSE  
ENST00000494279 ENSG00000116151 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN1 protein_coding protein_coding 11.02455 15.91949 9.092227 1.072451 0.3440885 -0.8074085 1.6858607 2.7777569 0.3991910 0.58384333 0.39919099 -2.76825851 0.13098750 0.17116667 0.04320000 -0.12796667 1.301928e-01 9.429651e-05    
ENST00000607031 ENSG00000116151 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN1 protein_coding retained_intron 11.02455 15.91949 9.092227 1.072451 0.3440885 -0.8074085 0.7640160 1.3090999 0.5302489 0.13261328 0.05357597 -1.28785784 0.06899167 0.08220000 0.05850000 -0.02370000 3.720399e-01 9.429651e-05 FALSE  
MSTRG.138.11 ENSG00000116151 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN1 protein_coding   11.02455 15.91949 9.092227 1.072451 0.3440885 -0.8074085 0.7409897 0.9334961 0.9212515 0.54087867 0.34971563 -0.01884567 0.07073333 0.05770000 0.10030000 0.04260000 7.269605e-01 9.429651e-05 FALSE  
MSTRG.138.12 ENSG00000116151 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN1 protein_coding   11.02455 15.91949 9.092227 1.072451 0.3440885 -0.8074085 1.0583551 1.9636954 0.7091434 0.14155875 0.04473926 -1.45654801 0.09474167 0.12360000 0.07850000 -0.04510000 7.923825e-02 9.429651e-05 FALSE  
MSTRG.138.15 ENSG00000116151 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN1 protein_coding   11.02455 15.91949 9.092227 1.072451 0.3440885 -0.8074085 0.8351505 1.3867720 1.0900712 0.27273546 0.54779521 -0.34449962 0.07572500 0.08963333 0.12183333 0.03220000 9.874791e-01 9.429651e-05 TRUE  
MSTRG.138.6 ENSG00000116151 HEK293_OSMI2_2hA HEK293_TMG_2hB MORN1 protein_coding   11.02455 15.91949 9.092227 1.072451 0.3440885 -0.8074085 1.4559657 2.4344147 1.6775117 0.22382274 0.11901144 -0.53459156 0.14410833 0.15253333 0.18550000 0.03296667 5.427375e-01 9.429651e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116151 E001 8.0005926 0.0022026180 5.851531e-04 2.478769e-03 1 2321253 2321579 327 - 1.146 0.763 -1.439
ENSG00000116151 E002 0.0000000       1 2324038 2324079 42 -      
ENSG00000116151 E003 0.2955422 0.0290289569 6.012021e-01   1 2324080 2324096 17 - 0.166 0.089 -1.027
ENSG00000116151 E004 3.8342706 0.0041643983 1.425926e-01 2.515691e-01 1 2324097 2324143 47 - 0.786 0.573 -0.898
ENSG00000116151 E005 8.1832160 0.0199001262 7.397060e-02 1.498646e-01 1 2332126 2332753 628 - 0.714 0.977 1.024
ENSG00000116151 E006 2.5024487 0.0062390949 5.659192e-01 6.929491e-01 1 2334903 2334937 35 - 0.578 0.485 -0.439
ENSG00000116151 E007 6.7544286 0.0031324016 6.142400e-01 7.327830e-01 1 2336469 2336545 77 - 0.901 0.841 -0.232
ENSG00000116151 E008 3.5782657 0.0045951736 6.782505e-01 7.827751e-01 1 2336546 2336548 3 - 0.578 0.646 0.298
ENSG00000116151 E009 6.2550464 0.0034061493 3.972754e-01 5.410339e-01 1 2336717 2336850 134 - 0.901 0.796 -0.408
ENSG00000116151 E010 5.0185106 0.0039682012 3.127280e-01 4.552504e-01 1 2349805 2349870 66 - 0.628 0.780 0.628
ENSG00000116151 E011 16.6829171 0.0022372459 3.567655e-01 5.011542e-01 1 2355175 2355464 290 - 1.259 1.181 -0.279
ENSG00000116151 E012 25.8084556 0.0008060166 6.353098e-02 1.325772e-01 1 2357432 2357598 167 - 1.474 1.347 -0.439
ENSG00000116151 E013 0.6234634 0.0191214541 7.429433e-01 8.317331e-01 1 2358588 2358591 4 - 0.166 0.226 0.558
ENSG00000116151 E014 19.7992799 0.0075990797 1.739376e-01 2.933026e-01 1 2358592 2358637 46 - 1.358 1.241 -0.409
ENSG00000116151 E015 20.6164562 0.0043137387 8.019823e-02 1.598556e-01 1 2358638 2358715 78 - 1.392 1.252 -0.489
ENSG00000116151 E016 11.3391821 0.0932422600 1.589947e-01 2.737831e-01 1 2371165 2371675 511 - 1.227 0.958 -0.972
ENSG00000116151 E017 1.4704484 0.0095539096 4.890978e-01 6.265963e-01 1 2371676 2371681 6 - 0.285 0.414 0.781
ENSG00000116151 E018 6.6396484 0.0024972573 2.077084e-01 3.357200e-01 1 2371682 2371905 224 - 0.949 0.796 -0.588
ENSG00000116151 E019 12.2601010 0.0628345732 6.188984e-01 7.364343e-01 1 2371906 2372480 575 - 1.117 1.055 -0.224
ENSG00000116151 E020 39.7349552 0.0051125727 2.019235e-03 7.285411e-03 1 2372481 2372591 111 - 1.701 1.507 -0.659
ENSG00000116151 E021 36.3467157 0.0008039994 9.779555e-03 2.821926e-02 1 2374461 2374557 97 - 1.631 1.480 -0.516
ENSG00000116151 E022 27.6754665 0.0007822744 1.395643e-02 3.812222e-02 1 2374853 2375598 746 - 1.270 1.457 0.647
ENSG00000116151 E023 75.7645508 0.0003615473 9.146572e-07 7.656375e-06 1 2375599 2377602 2004 - 1.667 1.897 0.775
ENSG00000116151 E024 28.1210619 0.0009838260 3.849590e-02 8.827184e-02 1 2377603 2378054 452 - 1.302 1.457 0.538
ENSG00000116151 E025 28.6412454 0.0203438077 1.647843e-01 2.814084e-01 1 2378055 2378606 552 - 1.321 1.464 0.495
ENSG00000116151 E026 22.4113526 0.0162097118 6.099855e-01 7.293792e-01 1 2378607 2378980 374 - 1.281 1.337 0.194
ENSG00000116151 E027 19.2930023 0.0010303485 7.287613e-02 1.481239e-01 1 2378981 2379108 128 - 1.146 1.305 0.561
ENSG00000116151 E028 29.2655494 0.0185589205 2.337806e-01 3.668832e-01 1 2379109 2379227 119 - 1.358 1.475 0.403
ENSG00000116151 E029 80.6443134 0.0004807067 6.245246e-01 7.408149e-01 1 2384978 2385065 88 - 1.882 1.864 -0.060
ENSG00000116151 E030 1.1155605 0.0140895124 1.936406e-01 3.183657e-01 1 2385066 2385158 93 - 0.456 0.226 -1.441
ENSG00000116151 E031 15.5496209 0.0011649415 3.839456e-01 5.281538e-01 1 2385372 2385806 435 - 1.116 1.200 0.298
ENSG00000116151 E032 113.9048637 0.0003634189 9.165398e-01 9.512513e-01 1 2385807 2385897 91 - 2.015 2.014 -0.004
ENSG00000116151 E033 56.5608094 0.0224745455 6.975124e-02 1.429578e-01 1 2385898 2387055 1158 - 1.596 1.757 0.546
ENSG00000116151 E034 20.3397828 0.0353163728 8.354522e-01 8.970919e-01 1 2387056 2387418 363 - 1.271 1.293 0.076
ENSG00000116151 E035 111.9424370 0.0002720100 1.373247e-01 2.443474e-01 1 2387419 2387529 111 - 2.042 1.993 -0.162
ENSG00000116151 E036 0.3697384 0.0274424043 4.729060e-01 6.119411e-01 1 2387530 2388003 474 - 0.000 0.163 8.849
ENSG00000116151 E037 18.3704192 0.0010293656 3.645471e-03 1.214262e-02 1 2388004 2388238 235 - 1.031 1.305 0.976
ENSG00000116151 E038 129.1306198 0.0003109540 8.986266e-01 9.393498e-01 1 2388239 2388337 99 - 2.068 2.067 -0.006
ENSG00000116151 E039 6.0495023 0.0028255395 4.849316e-02 1.064961e-01 1 2388338 2388509 172 - 0.578 0.869 1.199
ENSG00000116151 E040 52.5401547 0.0004716093 3.047578e-01 4.467864e-01 1 2389925 2389996 72 - 1.716 1.667 -0.168
ENSG00000116151 E041 62.6502088 0.0006071373 1.518086e-01 2.641229e-01 1 2391458 2391707 250 - 1.801 1.736 -0.219