ENSG00000116141

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366917 ENSG00000116141 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK1 protein_coding protein_coding 6.214297 3.85306 8.495814 0.3777471 0.3256542 1.138705 1.0952388 0.24054149 3.3068267 0.24054149 0.33036346 3.7266822 0.15626667 0.053866667 0.38856667 0.334700000 0.0452305625 0.0006027895 FALSE TRUE
ENST00000402574 ENSG00000116141 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK1 protein_coding protein_coding 6.214297 3.85306 8.495814 0.3777471 0.3256542 1.138705 0.9692302 0.64732869 0.4803306 0.06037225 0.29387841 -0.4228601 0.16153333 0.171366667 0.05843333 -0.112933333 0.3625670747 0.0006027895 FALSE TRUE
ENST00000485104 ENSG00000116141 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK1 protein_coding retained_intron 6.214297 3.85306 8.495814 0.3777471 0.3256542 1.138705 0.6241382 0.41502959 1.0883770 0.11981537 0.08480927 1.3697381 0.09739583 0.107233333 0.12796667 0.020733333 0.7943288589 0.0006027895   FALSE
ENST00000611084 ENSG00000116141 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK1 protein_coding protein_coding 6.214297 3.85306 8.495814 0.3777471 0.3256542 1.138705 0.3234027 0.18813786 0.3630641 0.10749780 0.03767758 0.9129189 0.05062917 0.051800000 0.04316667 -0.008633333 1.0000000000 0.0006027895 FALSE TRUE
ENST00000677041 ENSG00000116141 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK1 protein_coding nonsense_mediated_decay 6.214297 3.85306 8.495814 0.3777471 0.3256542 1.138705 0.2349239 0.02493222 0.6877177 0.02493222 0.14403229 4.3200133 0.03197083 0.006333333 0.08076667 0.074433333 0.0006027895 0.0006027895 FALSE TRUE
ENST00000678409 ENSG00000116141 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK1 protein_coding processed_transcript 6.214297 3.85306 8.495814 0.3777471 0.3256542 1.138705 0.9756596 0.12307151 1.6672751 0.12307151 0.25258058 3.6558457 0.12624167 0.027566667 0.19486667 0.167300000 0.0496663143 0.0006027895 FALSE FALSE
ENST00000678435 ENSG00000116141 HEK293_OSMI2_2hA HEK293_TMG_2hB MARK1 protein_coding protein_coding 6.214297 3.85306 8.495814 0.3777471 0.3256542 1.138705 1.3928657 2.02817541 0.3249450 0.15723569 0.32494504 -2.6052819 0.27279167 0.534866667 0.03923333 -0.495633333 0.0136677387 0.0006027895 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116141 E001 2.0808557 0.0071155859 9.767560e-04 3.880303e-03 1 220528136 220528182 47 + 0.633 0.000 -12.115
ENSG00000116141 E002 3.0858006 0.0302231895 1.490787e-02 4.027855e-02 1 220528183 220528220 38 + 0.719 0.280 -2.229
ENSG00000116141 E003 2.4860817 0.0145363924 4.403339e-02 9.844803e-02 1 220528221 220528225 5 + 0.633 0.279 -1.867
ENSG00000116141 E004 10.5059136 0.1673124328 3.238035e-02 7.658855e-02 1 220528226 220528365 140 + 1.166 0.750 -1.564
ENSG00000116141 E005 7.1341478 0.1740894835 8.130535e-02 1.615931e-01 1 220528366 220528376 11 + 0.998 0.669 -1.286
ENSG00000116141 E006 11.5190205 0.1698911400 2.540452e-01 3.906755e-01 1 220528377 220528422 46 + 1.137 0.978 -0.580
ENSG00000116141 E007 17.6962277 0.0166237954 4.201897e-02 9.475387e-02 1 220528423 220528552 130 + 1.317 1.124 -0.683
ENSG00000116141 E008 17.1583772 0.0196404659 5.892709e-03 1.832856e-02 1 220528553 220528662 110 + 1.332 1.042 -1.031
ENSG00000116141 E009 7.4222743 0.0023027681 8.194861e-02 1.626111e-01 1 220528663 220528670 8 + 0.976 0.775 -0.771
ENSG00000116141 E010 11.2577926 0.0015155561 2.375950e-01 3.713681e-01 1 220528671 220528713 43 + 1.106 1.001 -0.382
ENSG00000116141 E011 20.2459375 0.0009730458 3.396092e-03 1.142709e-02 1 220528714 220528815 102 + 1.385 1.162 -0.783
ENSG00000116141 E012 25.7399604 0.0007917988 3.064604e-04 1.405661e-03 1 220528816 220528873 58 + 1.496 1.247 -0.863
ENSG00000116141 E013 0.1817044 0.0394455362 2.696585e-01   1 220529672 220529771 100 + 0.000 0.162 11.026
ENSG00000116141 E014 0.2924217 0.0290785164 4.200449e-01   1 220551106 220551301 196 + 0.167 0.000 -11.864
ENSG00000116141 E015 1.9637957 0.0070021849 2.058770e-02 5.272428e-02 1 220576646 220576736 91 + 0.582 0.162 -2.646
ENSG00000116141 E016 61.4035050 0.0004520611 4.544047e-03 1.466528e-02 1 220579354 220579557 204 + 1.822 1.708 -0.385
ENSG00000116141 E017 32.9028370 0.0050011984 7.319594e-02 1.486334e-01 1 220581065 220581118 54 + 1.556 1.448 -0.371
ENSG00000116141 E018 10.5074160 0.0016550356 5.010513e-01 6.372365e-01 1 220581119 220581427 309 + 1.072 1.020 -0.192
ENSG00000116141 E019 1.1156622 0.0117692682 2.166725e-01 3.463816e-01 1 220593998 220594042 45 + 0.382 0.162 -1.645
ENSG00000116141 E020 0.2924217 0.0290785164 4.200449e-01   1 220598303 220598330 28 + 0.167 0.000 -11.864
ENSG00000116141 E021 26.2616590 0.0007332851 7.413702e-02 1.501629e-01 1 220598331 220598379 49 + 1.462 1.355 -0.371
ENSG00000116141 E022 27.1002935 0.0007566894 5.994516e-01 7.208235e-01 1 220599798 220599863 66 + 1.437 1.419 -0.060
ENSG00000116141 E023 29.9064093 0.0073664500 6.407633e-01 7.539598e-01 1 220604067 220604137 71 + 1.447 1.504 0.195
ENSG00000116141 E024 25.7638080 0.0009382126 3.400284e-01 4.839698e-01 1 220615939 220615995 57 + 1.429 1.380 -0.169
ENSG00000116141 E025 57.0748587 0.0004530354 3.031513e-02 7.258550e-02 1 220618310 220618546 237 + 1.781 1.696 -0.289
ENSG00000116141 E026 51.6276082 0.0013970821 6.046343e-02 1.274094e-01 1 220618636 220618755 120 + 1.735 1.655 -0.270
ENSG00000116141 E027 0.0000000       1 220629416 220631034 1619 +      
ENSG00000116141 E028 47.8275559 0.0106335041 7.550766e-01 8.405234e-01 1 220631035 220631134 100 + 1.674 1.672 -0.008
ENSG00000116141 E029 0.2955422 0.0294525819 6.587468e-01   1 220631812 220632200 389 + 0.092 0.161 0.937
ENSG00000116141 E030 46.5578736 0.0005397891 4.591131e-01 5.993412e-01 1 220632201 220632313 113 + 1.639 1.696 0.195
ENSG00000116141 E031 50.9364375 0.0004446958 1.508984e-01 2.628881e-01 1 220635376 220635529 154 + 1.662 1.752 0.305
ENSG00000116141 E032 1.2534455 0.1050639327 7.302995e-01 8.223064e-01 1 220635530 220635832 303 + 0.288 0.377 0.555
ENSG00000116141 E033 65.1886816 0.0018687626 5.704770e-01 6.969488e-01 1 220635833 220636026 194 + 1.785 1.832 0.158
ENSG00000116141 E034 2.5560114 0.0136081055 1.570931e-01 2.712285e-01 1 220636027 220637669 1643 + 0.608 0.372 -1.174
ENSG00000116141 E035 5.5872051 0.0029505149 4.041961e-01 5.478985e-01 1 220647962 220650619 2658 + 0.837 0.741 -0.382
ENSG00000116141 E036 43.4845583 0.0005982843 1.277932e-01 2.310978e-01 1 220650620 220650720 101 + 1.592 1.692 0.341
ENSG00000116141 E037 50.2589881 0.0081682941 1.029351e-01 1.949412e-01 1 220651986 220652150 165 + 1.648 1.773 0.424
ENSG00000116141 E038 1.8132227 0.0083443572 8.875809e-01 9.321382e-01 1 220653098 220653100 3 + 0.459 0.447 -0.063
ENSG00000116141 E039 70.9112655 0.0117778165 3.195167e-01 4.625986e-01 1 220653101 220653352 252 + 1.811 1.898 0.291
ENSG00000116141 E040 11.2940954 0.0063277836 3.195515e-06 2.376092e-05 1 220655289 220657789 2501 + 1.224 0.663 -2.127
ENSG00000116141 E041 31.2532123 0.0006909008 2.531211e-03 8.856739e-03 1 220657790 220657834 45 + 1.397 1.605 0.711
ENSG00000116141 E042 263.4997590 0.0043015780 4.784138e-08 5.184125e-07 1 220661812 220664461 2650 + 2.324 2.519 0.649