ENSG00000116138

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375838 ENSG00000116138 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC16 protein_coding protein_coding 5.986141 3.705644 7.151042 0.8627543 0.1583311 0.9465574 0.4800557 0.04704514 0.7603698 0.03571445 0.06459210 3.7553752 0.06925417 0.01243333 0.10650000 0.09406667 1.823218e-04 2.340975e-07 FALSE TRUE
ENST00000375847 ENSG00000116138 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC16 protein_coding protein_coding 5.986141 3.705644 7.151042 0.8627543 0.1583311 0.9465574 3.3428416 2.08456030 3.9186308 0.21106129 0.06739221 0.9073792 0.56782500 0.60440000 0.54823333 -0.05616667 8.543037e-01 2.340975e-07 FALSE TRUE
ENST00000490811 ENSG00000116138 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC16 protein_coding processed_transcript 5.986141 3.705644 7.151042 0.8627543 0.1583311 0.9465574 1.1703327 0.13152157 1.7580536 0.13152157 0.10846125 3.6430681 0.15424583 0.03670000 0.24576667 0.20906667 6.400089e-02 2.340975e-07 FALSE FALSE
ENST00000495523 ENSG00000116138 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC16 protein_coding processed_transcript 5.986141 3.705644 7.151042 0.8627543 0.1583311 0.9465574 0.5003474 1.32285919 0.0000000 0.77630495 0.00000000 -7.0583806 0.11668333 0.31556667 0.00000000 -0.31556667 2.340975e-07 2.340975e-07   FALSE
ENST00000616884 ENSG00000116138 HEK293_OSMI2_2hA HEK293_TMG_2hB DNAJC16 protein_coding protein_coding 5.986141 3.705644 7.151042 0.8627543 0.1583311 0.9465574 0.3259055 0.00000000 0.5717599 0.00000000 0.05048452 5.8623520 0.06095000 0.00000000 0.07986667 0.07986667 3.100362e-07 2.340975e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116138 E001 0.1515154 0.0441884118 8.350319e-01   1 15526813 15526847 35 + 0.090 0.000 -9.977
ENSG00000116138 E002 0.4355181 0.6594433117 4.831667e-01 6.212214e-01 1 15526848 15526860 13 + 0.226 0.000 -11.549
ENSG00000116138 E003 12.0615911 0.0059895608 8.057594e-02 1.604566e-01 1 15526861 15526958 98 + 1.142 1.029 -0.407
ENSG00000116138 E004 21.4420353 0.0026442386 1.194626e-02 3.340343e-02 1 15529088 15529272 185 + 1.383 1.257 -0.442
ENSG00000116138 E005 15.4416763 0.0017084697 1.734921e-02 4.571102e-02 1 15534237 15534303 67 + 1.255 1.114 -0.502
ENSG00000116138 E006 39.9948586 0.0005653765 1.388202e-04 6.984403e-04 1 15536475 15536814 340 + 1.652 1.510 -0.483
ENSG00000116138 E007 30.9819502 0.0006962033 5.112908e-03 1.623766e-02 1 15544399 15544583 185 + 1.532 1.429 -0.356
ENSG00000116138 E008 22.0498634 0.0081007676 3.191228e-03 1.082990e-02 1 15546767 15546871 105 + 1.412 1.222 -0.661
ENSG00000116138 E009 29.0864866 0.0120133006 7.585342e-02 1.528678e-01 1 15548270 15548428 159 + 1.495 1.426 -0.240
ENSG00000116138 E010 24.3742781 0.0008285719 3.382652e-01 4.821231e-01 1 15559526 15559607 82 + 1.396 1.405 0.034
ENSG00000116138 E011 23.3896937 0.0008785339 3.305388e-01 4.741286e-01 1 15559608 15559656 49 + 1.375 1.381 0.021
ENSG00000116138 E012 0.1451727 0.0444183847 8.350989e-01   1 15560131 15560329 199 + 0.090 0.000 -9.974
ENSG00000116138 E013 36.7251017 0.0005514960 5.346833e-01 6.666896e-01 1 15562142 15562325 184 + 1.552 1.594 0.143
ENSG00000116138 E014 34.4169566 0.0047520845 9.713738e-01 9.861203e-01 1 15563929 15564085 157 + 1.508 1.584 0.258
ENSG00000116138 E015 17.7349448 0.0010949245 8.024460e-01 8.741511e-01 1 15564086 15564111 26 + 1.244 1.299 0.194
ENSG00000116138 E016 23.1827027 0.0083813484 6.023168e-01 7.232910e-01 1 15564283 15564359 77 + 1.358 1.382 0.084
ENSG00000116138 E017 1.7661956 0.1655132114 4.397821e-01 5.815191e-01 1 15565182 15565453 272 + 0.486 0.371 -0.610
ENSG00000116138 E018 0.3030308 0.3925282602 5.178240e-01   1 15565818 15565918 101 + 0.165 0.000 -10.982
ENSG00000116138 E019 28.8065191 0.0011925690 4.807073e-02 1.057538e-01 1 15565919 15565999 81 + 1.479 1.421 -0.200
ENSG00000116138 E020 32.9266943 0.0006557071 1.882371e-01 3.115194e-01 1 15566082 15566180 99 + 1.520 1.516 -0.014
ENSG00000116138 E021 3.5525518 0.0043105426 3.811983e-02 8.757913e-02 1 15566181 15566299 119 + 0.729 0.454 -1.241
ENSG00000116138 E022 3.4498748 0.1105062192 2.864681e-01 4.268631e-01 1 15566300 15566410 111 + 0.690 0.523 -0.739
ENSG00000116138 E023 3.2670245 0.0156642817 2.090658e-01 3.374159e-01 1 15566411 15566595 185 + 0.669 0.520 -0.669
ENSG00000116138 E024 1.8005252 0.0611743421 1.539626e-01 2.670581e-01 1 15567046 15567098 53 + 0.518 0.283 -1.317
ENSG00000116138 E025 43.6559735 0.0006699268 1.436058e-01 2.529186e-01 1 15567099 15567269 171 + 1.643 1.642 -0.002
ENSG00000116138 E026 59.7928430 0.0004086758 3.355693e-02 7.888482e-02 1 15567778 15568158 381 + 1.783 1.765 -0.062
ENSG00000116138 E027 26.3632757 0.0009378681 2.743063e-01 4.134415e-01 1 15568159 15568235 77 + 1.427 1.429 0.006
ENSG00000116138 E028 67.7027068 0.0063413863 7.508521e-01 8.374447e-01 1 15568236 15568776 541 + 1.804 1.855 0.171
ENSG00000116138 E029 32.6048284 0.0017365742 1.004873e-01 1.911922e-01 1 15568777 15568971 195 + 1.526 1.497 -0.099
ENSG00000116138 E030 79.3926113 0.0038034368 4.312318e-01 5.737976e-01 1 15568972 15569652 681 + 1.880 1.916 0.120
ENSG00000116138 E031 250.7021943 0.0188533456 3.807237e-06 2.783965e-05 1 15569653 15572137 2485 + 2.234 2.566 1.107
ENSG00000116138 E032 2.1035786 0.0072182912 2.368340e-01 3.705170e-01 1 15574760 15575149 390 + 0.376 0.626 1.229
ENSG00000116138 E033 0.5922303 0.0179184126 6.120805e-01 7.310906e-01 1 15575150 15575334 185 + 0.228 0.165 -0.579
ENSG00000116138 E034 0.7405235 0.0150124159 9.129808e-01 9.488832e-01 1 15575335 15575472 138 + 0.228 0.284 0.420
ENSG00000116138 E035 0.5932745 0.0205270559 6.196469e-01 7.369898e-01 1 15575473 15576092 620 + 0.164 0.283 1.004
ENSG00000116138 E036 0.3030308 0.3925282602 5.178240e-01   1 15592259 15592379 121 + 0.165 0.000 -10.982