ENSG00000116120

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
MSTRG.20017.14 ENSG00000116120 HEK293_OSMI2_2hA HEK293_TMG_2hB FARSB protein_coding   81.20031 77.12129 102.4886 4.852025 3.135796 0.4102163 62.04977 65.901099 74.75440 5.533780 2.9603988 0.181830 0.7725083 0.8524000 0.7289667 -0.1234333 0.001151084 2.468643e-05 FALSE TRUE
MSTRG.20017.15 ENSG00000116120 HEK293_OSMI2_2hA HEK293_TMG_2hB FARSB protein_coding   81.20031 77.12129 102.4886 4.852025 3.135796 0.4102163 15.16981 9.463973 21.24888 1.023477 0.4959581 1.166024 0.1804125 0.1249333 0.2075333 0.0826000 0.046211111 2.468643e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116120 E001 3.5022905 0.0042916545 9.824509e-05 5.137824e-04 2 222559827 222559839 13 - 0.860 0.234 -3.129
ENSG00000116120 E002 9.5207368 0.0017179606 1.531360e-07 1.500447e-06 2 222559840 222560140 301 - 1.224 0.624 -2.295
ENSG00000116120 E003 10.4076886 0.0043011417 5.158012e-05 2.896177e-04 2 222560141 222560529 389 - 1.216 0.778 -1.628
ENSG00000116120 E004 4.6982907 0.0033797390 4.545808e-04 1.984811e-03 2 222561662 222561998 337 - 0.941 0.444 -2.116
ENSG00000116120 E005 2.4098091 0.0072691849 4.479524e-04 1.959186e-03 2 222562657 222562681 25 - 0.737 0.132 -3.644
ENSG00000116120 E006 3.1701254 0.0052551354 5.383188e-02 1.159568e-01 2 222563851 222563912 62 - 0.737 0.445 -1.321
ENSG00000116120 E007 4.5101378 0.0044375807 2.661125e-01 4.042678e-01 2 222566899 222567021 123 - 0.803 0.660 -0.585
ENSG00000116120 E008 15.3645047 0.0011301786 6.777421e-03 2.064381e-02 2 222567022 222567490 469 - 1.314 1.094 -0.782
ENSG00000116120 E009 2.2487287 0.0067190634 7.015458e-03 2.126390e-02 2 222567491 222567509 19 - 0.687 0.234 -2.438
ENSG00000116120 E010 3.1572270 0.0429685427 2.083960e-02 5.324844e-02 2 222567510 222567511 2 - 0.781 0.384 -1.828
ENSG00000116120 E011 5.0961297 0.0031504094 8.271468e-04 3.356621e-03 2 222567512 222567580 69 - 0.955 0.497 -1.907
ENSG00000116120 E012 19.3329283 0.0068820428 5.194340e-12 1.133440e-10 2 222567581 222569026 1446 - 1.524 0.870 -2.336
ENSG00000116120 E013 5.0712539 0.0032322187 2.395375e-06 1.831819e-05 2 222569027 222569157 131 - 1.009 0.316 -3.107
ENSG00000116120 E014 3.8178931 0.0062477788 3.742004e-05 2.172376e-04 2 222569158 222569216 59 - 0.894 0.234 -3.260
ENSG00000116120 E015 5.0208894 0.0063530113 4.101718e-05 2.358581e-04 2 222569217 222569324 108 - 0.983 0.385 -2.595
ENSG00000116120 E016 5.0230544 0.0171053717 1.670392e-06 1.321353e-05 2 222569325 222569386 62 - 1.009 0.234 -3.687
ENSG00000116120 E017 7.3596097 0.0183111519 8.759709e-07 7.363776e-06 2 222569387 222569546 160 - 1.148 0.444 -2.877
ENSG00000116120 E018 17.9065293 0.0014789589 4.618215e-20 2.953771e-18 2 222569547 222570894 1348 - 1.531 0.624 -3.362
ENSG00000116120 E019 25.6539599 0.0102798489 3.635719e-07 3.306337e-06 2 222570895 222571736 842 - 1.595 1.170 -1.474
ENSG00000116120 E020 878.2370023 0.0039394253 4.379448e-13 1.138723e-11 2 222571737 222572022 286 - 2.807 3.050 0.810
ENSG00000116120 E021 0.1515154 0.0434271222 5.678541e-01   2 222596321 222596369 49 - 0.113 0.000 -8.953
ENSG00000116120 E022 915.7270827 0.0026390859 2.337486e-16 9.622549e-15 2 222599928 222600083 156 - 2.833 3.064 0.768
ENSG00000116120 E023 810.5624641 0.0017202597 6.403902e-12 1.375822e-10 2 222613811 222613928 118 - 2.818 2.988 0.565
ENSG00000116120 E024 735.3029157 0.0016325363 6.007574e-06 4.201399e-05 2 222619645 222619737 93 - 2.807 2.923 0.387
ENSG00000116120 E025 639.4170115 0.0006313592 8.233284e-06 5.576984e-05 2 222623650 222623730 81 - 2.760 2.854 0.313
ENSG00000116120 E026 717.0833965 0.0002119860 2.238596e-07 2.125791e-06 2 222624272 222624403 132 - 2.812 2.900 0.294
ENSG00000116120 E027 561.1362750 0.0001303059 1.059543e-02 3.020010e-02 2 222624404 222624479 76 - 2.726 2.780 0.180
ENSG00000116120 E028 471.5694524 0.0001976938 9.652179e-01 9.821077e-01 2 222624714 222624775 62 - 2.672 2.686 0.047
ENSG00000116120 E029 420.0508058 0.0005104800 7.149106e-01 8.109797e-01 2 222628837 222628888 52 - 2.625 2.632 0.024
ENSG00000116120 E030 418.7361128 0.0001801842 1.291487e-02 3.571437e-02 2 222630113 222630174 62 - 2.642 2.612 -0.099
ENSG00000116120 E031 464.7674751 0.0010351324 8.624307e-02 1.693845e-01 2 222631604 222631674 71 - 2.683 2.657 -0.087
ENSG00000116120 E032 556.6123814 0.0013290525 1.444743e-05 9.247635e-05 2 222633199 222633307 109 - 2.789 2.701 -0.294
ENSG00000116120 E033 622.3834693 0.0019703008 4.153055e-06 3.008734e-05 2 222634391 222634541 151 - 2.846 2.738 -0.358
ENSG00000116120 E034 513.8326050 0.0043201685 2.975169e-04 1.369580e-03 2 222639580 222639691 112 - 2.767 2.648 -0.397
ENSG00000116120 E035 234.3173717 0.0068292080 9.042036e-03 2.638368e-02 2 222639692 222639695 4 - 2.425 2.311 -0.379
ENSG00000116120 E036 429.0187470 0.0050223481 2.099209e-03 7.531702e-03 2 222640862 222640931 70 - 2.685 2.575 -0.365
ENSG00000116120 E037 639.6652631 0.0043545651 5.810317e-07 5.077715e-06 2 222642851 222643005 155 - 2.881 2.718 -0.543
ENSG00000116120 E038 50.7673813 0.0005605503 2.254027e-20 1.504116e-18 2 222646801 222646970 170 - 1.890 1.408 -1.639
ENSG00000116120 E039 19.9351074 0.0044907752 5.927015e-08 6.289448e-07 2 222646971 222646996 26 - 1.496 1.040 -1.604
ENSG00000116120 E040 11.6549743 0.0014411343 2.828196e-08 3.199721e-07 2 222647113 222647325 213 - 1.301 0.722 -2.152
ENSG00000116120 E041 445.7403571 0.0020098268 8.519560e-16 3.248149e-14 2 222648740 222648795 56 - 2.743 2.533 -0.699
ENSG00000116120 E042 367.0143540 0.0028615840 8.994701e-14 2.572493e-12 2 222656016 222656092 77 - 2.666 2.437 -0.764