ENSG00000116117

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358768 ENSG00000116117 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3B protein_coding protein_coding 1.682409 1.354604 2.102999 0.1560901 0.1654929 0.6308093 0.25101712 0.15019776 0.4128739 0.07587996 0.25103284 1.400374 0.15068333 0.12550000 0.1914333 0.06593333 9.554051e-01 3.799149e-08 FALSE TRUE
ENST00000406610 ENSG00000116117 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3B protein_coding protein_coding 1.682409 1.354604 2.102999 0.1560901 0.1654929 0.6308093 0.51482094 0.13818687 0.9717845 0.04703283 0.03902636 2.727989 0.29951250 0.10013333 0.4660000 0.36586667 1.764677e-05 3.799149e-08 FALSE TRUE
ENST00000471958 ENSG00000116117 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3B protein_coding processed_transcript 1.682409 1.354604 2.102999 0.1560901 0.1654929 0.6308093 0.07792173 0.04697273 0.2704017 0.04697273 0.08799238 2.299152 0.03845417 0.02820000 0.1245667 0.09636667 1.599974e-01 3.799149e-08 FALSE FALSE
ENST00000488622 ENSG00000116117 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3B protein_coding processed_transcript 1.682409 1.354604 2.102999 0.1560901 0.1654929 0.6308093 0.34463248 0.71576979 0.0000000 0.09754634 0.00000000 -6.181440 0.23990417 0.55636667 0.0000000 -0.55636667 3.799149e-08 3.799149e-08 FALSE FALSE
ENST00000613457 ENSG00000116117 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3B protein_coding protein_coding 1.682409 1.354604 2.102999 0.1560901 0.1654929 0.6308093 0.16792448 0.06930981 0.2980930 0.06930981 0.29809302 1.957795 0.08922083 0.04160000 0.1384333 0.09683333 9.853578e-01 3.799149e-08 FALSE TRUE
ENST00000614500 ENSG00000116117 HEK293_OSMI2_2hA HEK293_TMG_2hB PARD3B protein_coding protein_coding 1.682409 1.354604 2.102999 0.1560901 0.1654929 0.6308093 0.11108220 0.15221742 0.0000000 0.15221742 0.00000000 -4.019857 0.06263333 0.09136667 0.0000000 -0.09136667 6.804197e-01 3.799149e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116117 E001 2.2905590 0.036128828 7.197006e-02 1.466108e-01 2 204545475 204545792 318 + 0.566 0.307 -1.384
ENSG00000116117 E002 1.5543139 0.009166505 2.966931e-01 4.379485e-01 2 204545793 204545841 49 + 0.423 0.307 -0.684
ENSG00000116117 E003 3.1741894 0.005071546 9.838154e-01 9.939518e-01 2 204545842 204545999 158 + 0.566 0.662 0.423
ENSG00000116117 E004 4.1976583 0.005258871 5.439983e-01 6.745131e-01 2 204546000 204546119 120 + 0.692 0.708 0.067
ENSG00000116117 E005 0.1817044 0.038423376 2.670614e-01   2 204546120 204546171 52 + 0.000 0.180 10.727
ENSG00000116117 E006 1.2317032 0.014624025 1.516245e-01 2.638644e-01 2 204558024 204558186 163 + 0.388 0.180 -1.492
ENSG00000116117 E007 5.1777248 0.003218174 5.563367e-01 6.850145e-01 2 204686181 204686282 102 + 0.759 0.788 0.114
ENSG00000116117 E008 6.8145427 0.002563023 7.517661e-02 1.518189e-01 2 204965152 204965323 172 + 0.904 0.788 -0.450
ENSG00000116117 E009 5.8944032 0.002944874 1.288565e-01 2.325655e-01 2 205047581 205047690 110 + 0.844 0.750 -0.373
ENSG00000116117 E010 1.6877315 0.011683974 5.764949e-01 7.019132e-01 2 205047691 205048595 905 + 0.423 0.405 -0.100
ENSG00000116117 E011 0.0000000       2 205103692 205103769 78 +      
ENSG00000116117 E012 6.6472465 0.002533536 1.774269e-01 2.979057e-01 2 205104426 205104514 89 + 0.881 0.823 -0.225
ENSG00000116117 E013 6.6871141 0.007406520 1.879889e-01 3.111828e-01 2 205113491 205113577 87 + 0.881 0.823 -0.225
ENSG00000116117 E014 6.5334973 0.002548821 5.323429e-02 1.149033e-01 2 205118921 205119046 126 + 0.892 0.750 -0.559
ENSG00000116117 E015 11.1864324 0.002169672 2.830915e-02 6.862200e-02 2 205121591 205121949 359 + 1.099 0.988 -0.405
ENSG00000116117 E016 7.5465465 0.006033995 1.164424e-01 2.148812e-01 2 205124327 205124466 140 + 0.936 0.855 -0.310
ENSG00000116117 E017 8.2370228 0.002175341 2.227194e-02 5.623778e-02 2 205125609 205125737 129 + 0.985 0.823 -0.617
ENSG00000116117 E018 8.1857544 0.002543630 4.845412e-02 1.064275e-01 2 205158722 205158907 186 + 0.976 0.855 -0.457
ENSG00000116117 E019 8.7075669 0.002044616 8.854600e-05 4.682029e-04 2 205172211 205172381 171 + 1.054 0.662 -1.521
ENSG00000116117 E020 7.7110661 0.002857168 5.994669e-04 2.531197e-03 2 205176445 205176577 133 + 1.003 0.662 -1.337
ENSG00000116117 E021 8.8484837 0.001961530 3.314207e-03 1.118953e-02 2 205185764 205185863 100 + 1.029 0.788 -0.917
ENSG00000116117 E022 11.5895475 0.010345836 1.030356e-02 2.951460e-02 2 205193205 205193320 116 + 1.120 0.941 -0.657
ENSG00000116117 E023 5.2372490 0.011516950 9.635450e-02 1.848985e-01 2 205245778 205245822 45 + 0.804 0.663 -0.573
ENSG00000116117 E024 0.0000000       2 205293492 205293811 320 +      
ENSG00000116117 E025 11.3246310 0.004996989 7.281914e-02 1.480301e-01 2 205300530 205300736 207 + 1.084 1.011 -0.268
ENSG00000116117 E026 15.5857267 0.006391099 2.862432e-01 4.266421e-01 2 205301464 205301701 238 + 1.189 1.215 0.092
ENSG00000116117 E027 0.0000000       2 205347809 205348171 363 +      
ENSG00000116117 E028 11.1008159 0.001598186 8.709674e-01 9.210403e-01 2 205401013 205401123 111 + 1.021 1.125 0.377
ENSG00000116117 E029 18.8979524 0.001078897 3.075670e-01 4.498008e-01 2 205440370 205440672 303 + 1.258 1.301 0.150
ENSG00000116117 E030 0.0000000       2 205482590 205482738 149 +      
ENSG00000116117 E031 11.3869820 0.001747730 6.202892e-01 7.375037e-01 2 205499896 205500031 136 + 1.037 1.108 0.255
ENSG00000116117 E032 6.2281641 0.003674962 2.902018e-02 7.004765e-02 2 205553324 205553403 80 + 0.892 0.708 -0.729
ENSG00000116117 E033 195.8131146 0.015940489 2.395405e-09 3.311217e-08 2 205615456 205620162 4707 + 2.127 2.462 1.117