ENSG00000116106

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000281821 ENSG00000116106 HEK293_OSMI2_2hA HEK293_TMG_2hB EPHA4 protein_coding protein_coding 4.011684 2.063253 4.641746 0.1037548 0.2561095 1.165876 2.8699500 1.2620150 3.0172425 0.04981248 0.06107299 1.250889 0.71321667 0.6133667 0.65513333 0.041766667 8.435383e-01 7.933367e-20 TRUE TRUE
ENST00000409854 ENSG00000116106 HEK293_OSMI2_2hA HEK293_TMG_2hB EPHA4 protein_coding protein_coding 4.011684 2.063253 4.641746 0.1037548 0.2561095 1.165876 0.2776534 0.1255550 0.3090336 0.06368652 0.08938006 1.234830 0.05940000 0.0606000 0.06546667 0.004866667 8.936240e-01 7.933367e-20 FALSE TRUE
ENST00000469354 ENSG00000116106 HEK293_OSMI2_2hA HEK293_TMG_2hB EPHA4 protein_coding processed_transcript 4.011684 2.063253 4.641746 0.1037548 0.2561095 1.165876 0.2366586 0.6526367 0.0000000 0.07322471 0.00000000 -6.050146 0.10562083 0.3144333 0.00000000 -0.314433333 7.933367e-20 7.933367e-20 FALSE FALSE
ENST00000541600 ENSG00000116106 HEK293_OSMI2_2hA HEK293_TMG_2hB EPHA4 protein_coding protein_coding 4.011684 2.063253 4.641746 0.1037548 0.2561095 1.165876 0.3429579 0.0000000 1.1862528 0.00000000 0.22843562 6.902378 0.06097917 0.0000000 0.25176667 0.251766667 1.689478e-09 7.933367e-20 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116106 E001 162.2588720 0.0002920539 4.878844e-11 9.082070e-10 2 221418027 221420444 2418 - 2.132 2.296 0.546
ENSG00000116106 E002 19.2584973 0.0012472374 1.326032e-01 2.377108e-01 2 221420445 221420552 108 - 1.249 1.364 0.403
ENSG00000116106 E003 0.4772466 0.0219415635 2.707304e-01 4.093726e-01 2 221421980 221422070 91 - 0.093 0.275 1.887
ENSG00000116106 E004 33.5377410 0.0159415412 1.203295e-01 2.204563e-01 2 221425209 221425598 390 - 1.477 1.607 0.444
ENSG00000116106 E005 33.5597697 0.0022029994 8.062005e-01 8.768035e-01 2 221425599 221425900 302 - 1.525 1.539 0.047
ENSG00000116106 E006 6.6618934 0.0031502900 5.133943e-01 6.482166e-01 2 221425901 221425914 14 - 0.913 0.829 -0.319
ENSG00000116106 E007 19.4849706 0.0009506588 6.561267e-01 7.658263e-01 2 221425915 221426142 228 - 1.319 1.282 -0.129
ENSG00000116106 E008 1.3609537 0.0105712100 8.784417e-01 9.259187e-01 2 221426435 221426463 29 - 0.342 0.367 0.154
ENSG00000116106 E009 20.1978430 0.0009524393 8.191369e-01 8.857934e-01 2 221426464 221426619 156 - 1.314 1.330 0.054
ENSG00000116106 E010 26.0171421 0.0007733667 9.614495e-01 9.797297e-01 2 221429958 221430151 194 - 1.425 1.426 0.005
ENSG00000116106 E011 22.2324483 0.0013461206 8.323046e-01 8.949283e-01 2 221434142 221434291 150 - 1.357 1.339 -0.064
ENSG00000116106 E012 12.3763718 0.0014787296 8.292145e-01 8.927418e-01 2 221436399 221436456 58 - 1.121 1.097 -0.083
ENSG00000116106 E013 22.7914396 0.0282996034 8.644284e-01 9.166048e-01 2 221436457 221436608 152 - 1.353 1.372 0.065
ENSG00000116106 E014 16.8387651 0.0230223198 8.740233e-01 9.230218e-01 2 221437061 221437122 62 - 1.243 1.222 -0.074
ENSG00000116106 E015 0.5212538 0.0213978824 2.698692e-01 4.084225e-01 2 221437123 221437496 374 - 0.093 0.275 1.889
ENSG00000116106 E016 21.9276427 0.0272629194 9.463543e-01 9.703352e-01 2 221442829 221443014 186 - 1.348 1.337 -0.038
ENSG00000116106 E017 13.9587220 0.0042902009 4.966929e-01 6.333253e-01 2 221443493 221443606 114 - 1.144 1.205 0.220
ENSG00000116106 E018 13.4063750 0.0188121066 9.488901e-01 9.719463e-01 2 221446123 221446181 59 - 1.151 1.154 0.009
ENSG00000116106 E019 15.1527753 0.0193701455 9.818221e-01 9.926576e-01 2 221455547 221455658 112 - 1.206 1.202 -0.014
ENSG00000116106 E020 18.9573464 0.0010291716 7.088602e-01 8.064148e-01 2 221456613 221456772 160 - 1.304 1.272 -0.112
ENSG00000116106 E021 10.0665837 0.0017806521 4.410447e-01 5.826912e-01 2 221457866 221457888 23 - 1.004 1.082 0.284
ENSG00000116106 E022 11.8704172 0.0144057316 7.999867e-01 8.724655e-01 2 221457889 221457953 65 - 1.088 1.113 0.092
ENSG00000116106 E023 10.8299990 0.0020245382 8.481705e-01 9.057356e-01 2 221457954 221457990 37 - 1.070 1.049 -0.079
ENSG00000116106 E024 16.1818629 0.0011643111 4.945430e-01 6.314853e-01 2 221482352 221482439 88 - 1.206 1.262 0.196
ENSG00000116106 E025 24.6170497 0.0009084358 6.270685e-01 7.429222e-01 2 221482440 221482690 251 - 1.417 1.381 -0.126
ENSG00000116106 E026 15.4362600 0.0012453546 4.902420e-01 6.275881e-01 2 221501017 221501172 156 - 1.231 1.168 -0.223
ENSG00000116106 E027 0.0000000       2 221501173 221501344 172 -      
ENSG00000116106 E028 0.0000000       2 221502528 221502560 33 -      
ENSG00000116106 E029 32.2425826 0.0116261414 1.042531e-02 2.980649e-02 2 221563731 221563992 262 - 1.588 1.378 -0.723
ENSG00000116106 E030 10.1081446 0.0221714066 4.030681e-02 9.159834e-02 2 221563993 221563996 4 - 1.128 0.857 -1.004
ENSG00000116106 E031 23.8057595 0.0009926576 1.219709e-02 3.400492e-02 2 221563997 221564105 109 - 1.451 1.262 -0.659
ENSG00000116106 E032 30.8379866 0.0042361761 6.745949e-03 2.056315e-02 2 221564106 221564278 173 - 1.561 1.364 -0.677
ENSG00000116106 E033 22.1213519 0.0009630304 2.588598e-03 9.031348e-03 2 221564279 221564394 116 - 1.432 1.194 -0.835
ENSG00000116106 E034 14.0753485 0.0110806665 2.333027e-03 8.253223e-03 2 221568718 221568785 68 - 1.272 0.932 -1.229
ENSG00000116106 E035 0.0000000       2 221569396 221569481 86 -      
ENSG00000116106 E036 11.7891722 0.0016409026 1.619789e-04 8.004804e-04 2 221572158 221572281 124 - 1.219 0.800 -1.549
ENSG00000116106 E037 1.9865846 0.0078792637 2.210750e-02 5.589633e-02 2 221572282 221572358 77 - 0.588 0.159 -2.695
ENSG00000116106 E038 0.0000000       2 221573850 221573960 111 -      
ENSG00000116106 E039 0.7406253 0.0155031950 7.725525e-02 1.550860e-01 2 221573961 221574223 263 - 0.342 0.001 -9.856