ENSG00000116062

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000411819 ENSG00000116062 HEK293_OSMI2_2hA HEK293_TMG_2hB MSH6 protein_coding protein_coding 52.23519 24.81002 83.85637 1.363497 2.634351 1.756588 6.977641 0.00000 14.17636 0.000000 1.073960 10.470289 0.0858875 0.0000 0.1688000 0.1688000 7.686883e-47 7.686883e-47 FALSE TRUE
MSTRG.18359.6 ENSG00000116062 HEK293_OSMI2_2hA HEK293_TMG_2hB MSH6 protein_coding   52.23519 24.81002 83.85637 1.363497 2.634351 1.756588 43.230989 23.47247 66.33566 1.273407 1.710958 1.498418 0.8699042 0.9462 0.7913667 -0.1548333 8.143028e-21 7.686883e-47 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116062 E001 0.0000000       2 47695530 47695815 286 +      
ENSG00000116062 E002 0.0000000       2 47695816 47695818 3 +      
ENSG00000116062 E003 0.0000000       2 47695819 47696097 279 +      
ENSG00000116062 E004 0.0000000       2 47708183 47708208 26 +      
ENSG00000116062 E005 0.0000000       2 47708209 47708430 222 +      
ENSG00000116062 E006 0.0000000       2 47708431 47709833 1403 +      
ENSG00000116062 E007 0.2987644 0.0274257727 5.761762e-01   2 47737391 47737506 116 + 0.159 0.000 -10.169
ENSG00000116062 E008 0.2998086 0.0288680747 5.219614e-01   2 47757689 47757793 105 + 0.087 0.170 1.115
ENSG00000116062 E009 2.3356104 0.0071270884 4.134628e-01 5.569409e-01 2 47783082 47783127 46 + 0.562 0.387 -0.882
ENSG00000116062 E010 3.2902053 0.0114538800 5.812098e-01 7.057791e-01 2 47783128 47783144 17 + 0.657 0.531 -0.560
ENSG00000116062 E011 4.4778882 0.0045802278 2.948742e-01 4.359872e-01 2 47783145 47783150 6 + 0.784 0.588 -0.821
ENSG00000116062 E012 34.5334535 0.0217700834 5.103302e-03 1.621236e-02 2 47783151 47783169 19 + 1.624 1.295 -1.134
ENSG00000116062 E013 42.4856147 0.0381229014 3.562210e-02 8.284942e-02 2 47783170 47783182 13 + 1.702 1.412 -0.989
ENSG00000116062 E014 88.4917029 0.0192376329 8.843369e-05 4.676613e-04 2 47783183 47783231 49 + 2.033 1.658 -1.265
ENSG00000116062 E015 224.8443616 0.0209661968 4.862047e-07 4.309644e-06 2 47783232 47783470 239 + 2.447 2.010 -1.460
ENSG00000116062 E016 110.4171811 0.0090667218 1.914421e-12 4.480314e-11 2 47783471 47783493 23 + 2.151 1.646 -1.702
ENSG00000116062 E017 0.1482932 0.0409578498 1.999879e-01   2 47783585 47783778 194 + 0.000 0.170 11.120
ENSG00000116062 E018 2.1487092 0.0067553052 4.070296e-02 9.232802e-02 2 47783955 47784105 151 + 0.588 0.170 -2.582
ENSG00000116062 E019 0.0000000       2 47784181 47784238 58 +      
ENSG00000116062 E020 0.4481018 0.0635720170 2.029213e-01 3.298709e-01 2 47784488 47784976 489 + 0.087 0.290 2.106
ENSG00000116062 E021 351.1531148 0.0100994279 2.836469e-09 3.868293e-08 2 47790927 47791123 197 + 2.628 2.258 -1.236
ENSG00000116062 E022 431.2562488 0.0001275804 4.418152e-37 1.262452e-34 2 47795894 47796063 170 + 2.704 2.403 -1.000
ENSG00000116062 E023 206.1030371 0.0010696535 1.042669e-15 3.925487e-14 2 47798611 47798614 4 + 2.386 2.077 -1.034
ENSG00000116062 E024 3140.5931470 0.0023222910 4.279763e-14 1.282002e-12 2 47798615 47800747 2133 + 3.535 3.357 -0.593
ENSG00000116062 E025 923.3924271 0.0002022081 4.441759e-05 2.534191e-04 2 47800748 47801155 408 + 2.947 2.956 0.030
ENSG00000116062 E026 649.1237142 0.0001477507 3.632401e-15 1.275056e-13 2 47803420 47803685 266 + 2.771 2.844 0.243
ENSG00000116062 E027 421.7247043 0.0031236164 7.631749e-10 1.156280e-08 2 47804910 47805027 118 + 2.551 2.700 0.499
ENSG00000116062 E028 359.8896609 0.0023750081 1.013755e-15 3.822710e-14 2 47805618 47805707 90 + 2.462 2.656 0.647
ENSG00000116062 E029 537.4412636 0.0015023703 9.078133e-28 1.259945e-25 2 47806204 47806358 155 + 2.628 2.839 0.704
ENSG00000116062 E030 596.2390032 0.0024558602 1.763492e-27 2.393182e-25 2 47806452 47806651 200 + 2.654 2.902 0.826
ENSG00000116062 E031 310.0685649 0.0020597952 5.733928e-26 6.840525e-24 2 47806779 47806900 122 + 2.363 2.630 0.891
ENSG00000116062 E032 135.5064016 0.0017190189 1.033486e-06 8.546455e-06 2 47806901 47809998 3098 + 2.067 2.203 0.456
ENSG00000116062 E033 6.3762658 0.0342648809 5.405194e-01 6.716616e-01 2 47809999 47810214 216 + 0.843 0.907 0.248