ENSG00000116017

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263620 ENSG00000116017 HEK293_OSMI2_2hA HEK293_TMG_2hB ARID3A protein_coding protein_coding 6.55422 7.794839 5.595078 0.5636492 0.1836936 -0.4776344 3.5581088 4.3059470 2.0696544 0.42453140 0.08552909 -1.0533334 0.53919583 0.55830000 0.37023333 -0.18806667 1.139821e-01 4.469102e-05 FALSE TRUE
ENST00000585733 ENSG00000116017 HEK293_OSMI2_2hA HEK293_TMG_2hB ARID3A protein_coding retained_intron 6.55422 7.794839 5.595078 0.5636492 0.1836936 -0.4776344 0.1805282 0.1218539 0.4038277 0.07197051 0.16151423 1.6500899 0.02920833 0.01653333 0.07133333 0.05480000 2.356230e-01 4.469102e-05 FALSE FALSE
ENST00000587532 ENSG00000116017 HEK293_OSMI2_2hA HEK293_TMG_2hB ARID3A protein_coding protein_coding 6.55422 7.794839 5.595078 0.5636492 0.1836936 -0.4776344 0.8630910 1.6069127 0.7603383 0.81317255 0.30311553 -1.0696778 0.12907917 0.20386667 0.13366667 -0.07020000 9.996843e-01 4.469102e-05 FALSE TRUE
MSTRG.16020.1 ENSG00000116017 HEK293_OSMI2_2hA HEK293_TMG_2hB ARID3A protein_coding   6.55422 7.794839 5.595078 0.5636492 0.1836936 -0.4776344 1.0920459 0.9927548 0.8045774 0.35838082 0.35543330 -0.2998452 0.16304583 0.12313333 0.14610000 0.02296667 9.898653e-01 4.469102e-05 FALSE TRUE
MSTRG.16020.3 ENSG00000116017 HEK293_OSMI2_2hA HEK293_TMG_2hB ARID3A protein_coding   6.55422 7.794839 5.595078 0.5636492 0.1836936 -0.4776344 0.4501890 0.4498670 1.1903227 0.04693810 0.15044526 1.3841336 0.07405000 0.05750000 0.21493333 0.15743333 4.469102e-05 4.469102e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000116017 E001 1.0601129 0.2933460258 0.7538663624 0.839654777 19 925752 925780 29 + 0.338 0.264 -0.490
ENSG00000116017 E002 4.1453272 0.0347071515 0.5337633033 0.665906215 19 925781 925920 140 + 0.726 0.657 -0.290
ENSG00000116017 E003 0.8491631 0.0163096919 0.3372653943 0.481139763 19 925987 926034 48 + 0.339 0.187 -1.132
ENSG00000116017 E004 2.2143831 0.0087416325 0.0989318295 0.188847292 19 926035 926059 25 + 0.618 0.371 -1.224
ENSG00000116017 E005 4.3094183 0.0038565178 0.0035316165 0.011816987 19 926060 926197 138 + 0.908 0.534 -1.549
ENSG00000116017 E006 0.8762330 0.1943097101 0.0670094992 0.138397076 19 928678 929145 468 + 0.471 0.102 -2.881
ENSG00000116017 E007 13.2104854 0.0562722574 0.1123112975 0.208922040 19 929262 929498 237 + 1.223 1.056 -0.599
ENSG00000116017 E008 45.0930590 0.0046985336 0.3001157292 0.441751504 19 929499 929896 398 + 1.654 1.631 -0.079
ENSG00000116017 E009 31.8514778 0.0013625199 0.0007445621 0.003059364 19 932418 932508 91 + 1.597 1.425 -0.592
ENSG00000116017 E010 26.9720020 0.0273640033 0.0806536545 0.160574140 19 932509 932564 56 + 1.501 1.373 -0.443
ENSG00000116017 E011 48.3249154 0.0005524096 0.0014056673 0.005324924 19 932565 932742 178 + 1.743 1.620 -0.418
ENSG00000116017 E012 41.5730198 0.0005890116 0.0007318150 0.003013720 19 960092 960164 73 + 1.694 1.550 -0.491
ENSG00000116017 E013 0.7697675 0.0282671473 0.5763297236 0.701786458 19 961762 961940 179 + 0.144 0.258 1.042
ENSG00000116017 E014 38.1182899 0.0006785598 0.0025500288 0.008912540 19 964248 964288 41 + 1.654 1.522 -0.449
ENSG00000116017 E015 70.8768153 0.0012192413 0.0020439018 0.007361987 19 964289 964431 143 + 1.897 1.802 -0.320
ENSG00000116017 E016 92.2427250 0.0034222038 0.9386695526 0.965491741 19 964833 965080 248 + 1.928 1.964 0.120
ENSG00000116017 E017 1.4016525 0.0104333478 0.0917257909 0.177822066 19 965081 965270 190 + 0.527 0.257 -1.550
ENSG00000116017 E018 71.5558109 0.0094210543 0.0334092370 0.078594327 19 966572 966786 215 + 1.727 1.898 0.579
ENSG00000116017 E019 50.6189804 0.0035918957 0.0091052236 0.026545564 19 966787 966868 82 + 1.561 1.754 0.655
ENSG00000116017 E020 55.7080962 0.0005760705 0.0357337001 0.083071250 19 968405 968503 99 + 1.639 1.782 0.484
ENSG00000116017 E021 1.3264216 0.0097622890 0.4264337443 0.569264439 19 968504 968795 292 + 0.252 0.417 1.035
ENSG00000116017 E022 724.3972292 0.0062599561 0.0168553671 0.044612078 19 971878 975939 4062 + 2.779 2.875 0.319