ENSG00000115947

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000392857 ENSG00000115947 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC4 protein_coding protein_coding 23.57395 7.347217 37.76312 0.9732873 1.522865 2.360128 2.458843 0.8517719 4.610933 0.10411581 0.1969410 2.422806 0.10836667 0.1224667 0.12223333 -0.0002333333 9.583712e-01 9.3057e-09 FALSE TRUE
ENST00000490200 ENSG00000115947 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC4 protein_coding processed_transcript 23.57395 7.347217 37.76312 0.9732873 1.522865 2.360128 1.625326 0.0000000 2.221581 0.00000000 0.3955247 7.801923 0.04507917 0.0000000 0.05836667 0.0583666667 9.305700e-09 9.3057e-09   FALSE
MSTRG.19312.6 ENSG00000115947 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC4 protein_coding   23.57395 7.347217 37.76312 0.9732873 1.522865 2.360128 12.880486 5.0762672 20.220665 0.88911719 0.7652640 1.991865 0.56555833 0.6820333 0.53556667 -0.1464666667 2.176632e-02 9.3057e-09 FALSE TRUE
MSTRG.19312.7 ENSG00000115947 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC4 protein_coding   23.57395 7.347217 37.76312 0.9732873 1.522865 2.360128 4.250471 0.7910485 7.652859 0.06262103 0.1984109 3.257921 0.14797917 0.1139667 0.20350000 0.0895333333 3.583970e-02 9.3057e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115947 E001 0.0000000       2 147930396 147930396 1 -      
ENSG00000115947 E002 270.9915995 0.0092186779 4.820634e-01 0.6202237085 2 147930397 147935259 4863 - 2.363 2.330 -0.108
ENSG00000115947 E003 46.5292055 0.0075137446 2.559219e-03 0.0089395459 2 147935260 147935370 111 - 1.542 1.761 0.746
ENSG00000115947 E004 241.4237940 0.0042215779 2.238831e-04 0.0010657584 2 147935371 147935698 328 - 2.269 2.420 0.506
ENSG00000115947 E005 6.6512737 0.0032201082 5.876410e-01 0.7109038099 2 147936313 147937015 703 - 0.804 0.886 0.318
ENSG00000115947 E006 1.4737619 0.0092396877 4.270328e-01 0.5698714356 2 147937977 147938145 169 - 0.384 0.223 -1.086
ENSG00000115947 E007 118.7119648 0.0003117447 2.662687e-01 0.4044434974 2 147938146 147938213 68 - 1.990 2.040 0.167
ENSG00000115947 E008 139.8938458 0.0002834226 1.443096e-02 0.0392019021 2 147938298 147938393 96 - 2.047 2.139 0.308
ENSG00000115947 E009 7.0253777 0.0023620314 1.283336e-01 0.2318273809 2 147938394 147938650 257 - 0.782 0.987 0.785
ENSG00000115947 E010 146.7889121 0.0003126134 4.571351e-02 0.1015095581 2 147939140 147939248 109 - 2.072 2.147 0.252
ENSG00000115947 E011 124.2167073 0.0002675210 4.042497e-02 0.0918007893 2 147943436 147943522 87 - 1.997 2.080 0.278
ENSG00000115947 E012 0.2903454 0.3315254047 1.000000e+00   2 147947675 147948050 376 - 0.119 0.000 -9.781
ENSG00000115947 E013 158.6683505 0.0002854449 9.799254e-01 0.9914746118 2 147948051 147948188 138 - 2.120 2.128 0.027
ENSG00000115947 E014 87.3826472 0.0163489593 6.797882e-01 0.7838715863 2 147948189 147948224 36 - 1.871 1.844 -0.089
ENSG00000115947 E015 0.1472490 0.0439577574 1.000000e+00   2 147951448 147951638 191 - 0.064 0.000 -8.780
ENSG00000115947 E016 126.8385946 0.0002973460 7.429664e-02 0.1504138387 2 147952373 147952471 99 - 2.040 1.977 -0.210
ENSG00000115947 E017 93.1708031 0.0012684484 6.714288e-02 0.1386060626 2 147952472 147952524 53 - 1.914 1.832 -0.275
ENSG00000115947 E018 72.8104153 0.0027430330 6.474887e-01 0.7591535935 2 147955347 147955395 49 - 1.784 1.815 0.102
ENSG00000115947 E019 46.5222470 0.0005322878 8.242382e-01 0.8892793814 2 147958298 147958300 3 - 1.601 1.593 -0.025
ENSG00000115947 E020 42.3106687 0.0005775347 8.417058e-01 0.9012577790 2 147958301 147958302 2 - 1.561 1.555 -0.022
ENSG00000115947 E021 118.4194490 0.0002557985 1.286036e-01 0.2322108941 2 147958303 147958383 81 - 2.009 1.955 -0.182
ENSG00000115947 E022 0.4502799 0.0333333138 6.585975e-01 0.7676771408 2 147958384 147958495 112 - 0.169 0.000 -10.365
ENSG00000115947 E023 0.0000000       2 147958592 147958790 199 -      
ENSG00000115947 E024 107.9035948 0.0002854307 2.431341e-01 0.3778591543 2 147958791 147958866 76 - 1.967 1.925 -0.141
ENSG00000115947 E025 2.2800741 0.1171456081 2.191234e-01 0.3493152935 2 147960248 147960306 59 - 0.384 0.643 1.254
ENSG00000115947 E026 122.6552159 0.0003019695 1.466281e-02 0.0397323481 2 147972739 147972829 91 - 2.033 1.942 -0.305
ENSG00000115947 E027 106.4913899 0.0002646309 4.118821e-05 0.0002367123 2 147973448 147973524 77 - 1.987 1.811 -0.593
ENSG00000115947 E028 91.3022066 0.0003746387 6.009582e-04 0.0025366456 2 147975902 147975975 74 - 1.917 1.758 -0.534
ENSG00000115947 E029 4.7828164 0.0729156254 5.725810e-01 0.6986670530 2 147981928 147982081 154 - 0.665 0.761 0.395
ENSG00000115947 E030 13.3834908 0.0013255198 8.246947e-01 0.8895638021 2 148020608 148020632 25 - 1.087 1.069 -0.065
ENSG00000115947 E031 75.2402729 0.0018853730 1.215569e-02 0.0339034622 2 148020633 148020763 131 - 1.827 1.693 -0.454
ENSG00000115947 E032 0.2924217 0.0272106242 1.000000e+00   2 148021448 148021604 157 - 0.119 0.000 -9.779