ENSG00000115944

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000234301 ENSG00000115944 HEK293_OSMI2_2hA HEK293_TMG_2hB COX7A2L protein_coding protein_coding 90.49435 126.1542 73.31278 25.06949 2.938487 -0.782969 8.930716 14.25507 7.34770 2.354157 0.4893116 -0.9551600 0.0976875 0.1154333 0.1010000 -0.01443333 0.693240105 0.002721174 FALSE  
ENST00000482463 ENSG00000115944 HEK293_OSMI2_2hA HEK293_TMG_2hB COX7A2L protein_coding processed_transcript 90.49435 126.1542 73.31278 25.06949 2.938487 -0.782969 26.191690 39.07695 16.96634 7.639674 1.3461320 -1.2031615 0.2819208 0.3102667 0.2311000 -0.07916667 0.002721174 0.002721174    
ENST00000607768 ENSG00000115944 HEK293_OSMI2_2hA HEK293_TMG_2hB COX7A2L protein_coding processed_transcript 90.49435 126.1542 73.31278 25.06949 2.938487 -0.782969 17.475568 22.28080 15.38574 4.898106 1.2556721 -0.5339174 0.1964625 0.1749333 0.2091333 0.03420000 0.177337246 0.002721174    
MSTRG.18277.6 ENSG00000115944 HEK293_OSMI2_2hA HEK293_TMG_2hB COX7A2L protein_coding   90.49435 126.1542 73.31278 25.06949 2.938487 -0.782969 36.445726 48.73747 32.21408 10.171880 1.2543304 -0.5971883 0.4064375 0.3841000 0.4396000 0.05550000 0.052997439 0.002721174    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115944 E001 4.0719237 1.059791e-01 9.340158e-01 9.624227e-01 2 42333546 42333869 324 - 0.641 0.688 0.199
ENSG00000115944 E002 17.4380603 2.130342e-02 6.754240e-01 7.807163e-01 2 42335562 42335745 184 - 1.264 1.201 -0.222
ENSG00000115944 E003 18.2067634 1.755125e-02 2.491354e-01 3.848966e-01 2 42349338 42350506 1169 - 1.328 1.208 -0.419
ENSG00000115944 E004 532.0997540 3.563737e-04 1.572906e-11 3.171202e-10 2 42350507 42350663 157 - 2.592 2.718 0.420
ENSG00000115944 E005 1501.5237139 7.754062e-05 5.538269e-03 1.738727e-02 2 42350664 42350851 188 - 3.119 3.146 0.090
ENSG00000115944 E006 1203.2577375 1.240472e-04 2.917049e-01 4.326011e-01 2 42350852 42350940 89 - 3.051 3.040 -0.039
ENSG00000115944 E007 2519.4863776 5.289323e-04 4.887420e-01 6.262645e-01 2 42350941 42351355 415 - 3.368 3.353 -0.050
ENSG00000115944 E008 511.8734064 2.256195e-04 9.415985e-01 9.672860e-01 2 42351356 42351359 4 - 2.673 2.672 -0.003
ENSG00000115944 E009 1.7379928 5.958916e-02 1.451296e-01 2.550147e-01 2 42352887 42353211 325 - 0.591 0.321 -1.407
ENSG00000115944 E010 1323.8944730 8.846899e-05 1.940480e-02 5.021008e-02 2 42353212 42353343 132 - 3.101 3.077 -0.080
ENSG00000115944 E011 4.7434584 6.115505e-03 6.664787e-12 1.428631e-10 2 42359106 42360038 933 - 1.176 0.220 -4.411
ENSG00000115944 E012 4.6144619 1.363233e-02 1.208943e-02 3.374796e-02 2 42360938 42361089 152 - 0.941 0.585 -1.439
ENSG00000115944 E013 891.5135927 8.102374e-04 9.045038e-02 1.758358e-01 2 42361090 42361848 759 - 2.934 2.896 -0.127
ENSG00000115944 E014 0.8062992 2.798929e-01 2.024593e-01 3.292875e-01 2 42365670 42365874 205 - 0.000 0.281 10.878
ENSG00000115944 E015 0.0000000       2 42368868 42369010 143 -      
ENSG00000115944 E016 0.0000000       2 42388445 42388448 4 -      
ENSG00000115944 E017 0.7749669 1.546152e-01 5.063606e-02 1.102905e-01 2 42388449 42388656 208 - 0.467 0.086 -3.134
ENSG00000115944 E018 0.1472490 4.709333e-02 2.302523e-01   2 42413699 42413760 62 - 0.171 0.000 -11.371
ENSG00000115944 E019 0.1472490 4.709333e-02 2.302523e-01   2 42415483 42415550 68 - 0.171 0.000 -11.371
ENSG00000115944 E020 0.0000000       2 42424821 42425088 268 -