ENSG00000115942

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000234296 ENSG00000115942 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC2 protein_coding protein_coding 17.88707 6.130809 25.60252 0.2774079 0.7844864 2.060348 6.488460 4.1320752 9.3332443 0.43224356 0.1385662 1.173570 0.45493750 0.6705333 0.36533333 -0.30520000 2.309160e-06 2.701182e-34 FALSE TRUE
ENST00000464147 ENSG00000115942 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC2 protein_coding retained_intron 17.88707 6.130809 25.60252 0.2774079 0.7844864 2.060348 3.711094 1.6810889 4.0398269 0.06259621 0.1604321 1.259908 0.24248750 0.2746333 0.15810000 -0.11653333 5.540768e-04 2.701182e-34 TRUE TRUE
ENST00000474877 ENSG00000115942 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC2 protein_coding processed_transcript 17.88707 6.130809 25.60252 0.2774079 0.7844864 2.060348 1.312790 0.0000000 0.6984326 0.00000000 0.4468120 6.146559 0.05042500 0.0000000 0.02633333 0.02633333 4.326218e-01 2.701182e-34 FALSE FALSE
MSTRG.19746.2 ENSG00000115942 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC2 protein_coding   17.88707 6.130809 25.60252 0.2774079 0.7844864 2.060348 1.379264 0.1336235 2.5904934 0.13362345 0.3389560 4.178422 0.05982917 0.0235000 0.10133333 0.07783333 1.408660e-01 2.701182e-34 TRUE TRUE
MSTRG.19746.4 ENSG00000115942 HEK293_OSMI2_2hA HEK293_TMG_2hB ORC2 protein_coding   17.88707 6.130809 25.60252 0.2774079 0.7844864 2.060348 4.650082 0.0000000 8.5782884 0.00000000 0.5329726 9.746227 0.17068750 0.0000000 0.33490000 0.33490000 2.701182e-34 2.701182e-34 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115942 E001 174.0133645 0.0071017427 1.701125e-18 9.106331e-17 2 200908977 200910453 1477 - 2.029 2.463 1.451
ENSG00000115942 E002 237.2731868 0.0009545743 1.279744e-12 3.084131e-11 2 200910454 200910959 506 - 2.254 2.468 0.714
ENSG00000115942 E003 254.8799317 0.0003258717 1.430739e-09 2.059957e-08 2 200910960 200911387 428 - 2.299 2.467 0.560
ENSG00000115942 E004 113.8881968 0.0002427417 3.502137e-02 8.169497e-02 2 200913295 200913398 104 - 1.974 2.072 0.332
ENSG00000115942 E005 70.8493357 0.0003346276 8.430369e-01 9.022266e-01 2 200913399 200913413 15 - 1.793 1.805 0.041
ENSG00000115942 E006 32.5871656 0.0026005162 6.648527e-01 7.726028e-01 2 200913414 200913806 393 - 1.452 1.503 0.176
ENSG00000115942 E007 14.8397407 0.0051540764 4.148421e-01 5.582432e-01 2 200913807 200913930 124 - 1.115 1.215 0.360
ENSG00000115942 E008 88.6852351 0.0003085980 6.768875e-01 7.817170e-01 2 200913931 200913992 62 - 1.883 1.922 0.132
ENSG00000115942 E009 0.2903454 0.3344877323 1.000000e+00   2 200920221 200920221 1 - 0.128 0.000 -8.605
ENSG00000115942 E010 133.6234347 0.0002823945 5.954065e-02 1.258344e-01 2 200920222 200920393 172 - 2.046 2.132 0.288
ENSG00000115942 E011 97.1984284 0.0003349253 4.658358e-01 6.054506e-01 2 200920993 200921139 147 - 1.920 1.971 0.172
ENSG00000115942 E012 0.8136755 0.0145140732 3.909616e-01 5.349076e-01 2 200921140 200921738 599 - 0.180 0.349 1.260
ENSG00000115942 E013 69.5748391 0.0004032196 3.016453e-01 4.434581e-01 2 200925836 200925932 97 - 1.796 1.766 -0.100
ENSG00000115942 E014 90.6403529 0.0003488256 6.939324e-03 2.106549e-02 2 200926768 200926900 133 - 1.925 1.826 -0.333
ENSG00000115942 E015 0.2987644 0.0272924080 8.788273e-01   2 200926901 200926904 4 - 0.128 0.000 -8.610
ENSG00000115942 E016 89.0923734 0.0003980761 2.055126e-03 7.396578e-03 2 200931339 200931448 110 - 1.920 1.801 -0.401
ENSG00000115942 E017 92.1025231 0.0003526451 1.542011e-06 1.229010e-05 2 200933876 200933974 99 - 1.949 1.747 -0.680
ENSG00000115942 E018 130.0560543 0.0084951646 1.137517e-03 4.429035e-03 2 200935699 200935892 194 - 2.092 1.922 -0.568
ENSG00000115942 E019 78.0486932 0.0010201724 7.275600e-04 2.998022e-03 2 200937906 200937966 61 - 1.869 1.718 -0.511
ENSG00000115942 E020 69.2857374 0.0003897438 2.553336e-04 1.197447e-03 2 200941248 200941279 32 - 1.822 1.651 -0.579
ENSG00000115942 E021 0.0000000       2 200942684 200942684 1 -      
ENSG00000115942 E022 79.4917086 0.0004496622 8.059177e-06 5.468043e-05 2 200942685 200942777 93 - 1.888 1.686 -0.683
ENSG00000115942 E023 1.6232010 0.0086457951 2.412385e-01 3.756428e-01 2 200943088 200943159 72 - 0.434 0.209 -1.478
ENSG00000115942 E024 69.7417037 0.0004073672 1.900631e-06 1.485984e-05 2 200949554 200949643 90 - 1.837 1.600 -0.800
ENSG00000115942 E025 57.7192797 0.0013289153 3.499828e-04 1.580115e-03 2 200957401 200957421 21 - 1.751 1.558 -0.655
ENSG00000115942 E026 100.1315002 0.0005739152 1.364202e-07 1.350517e-06 2 200957422 200957544 123 - 1.989 1.771 -0.736
ENSG00000115942 E027 88.1945906 0.0004367572 9.471801e-10 1.410363e-08 2 200958030 200958133 104 - 1.944 1.663 -0.949
ENSG00000115942 E028 54.1274131 0.0043192582 7.727780e-05 4.151591e-04 2 200959392 200959440 49 - 1.732 1.477 -0.867
ENSG00000115942 E029 1.5123819 0.0094546105 2.282600e-01 3.603447e-01 2 200963049 200963218 170 - 0.308 0.539 1.257
ENSG00000115942 E030 1.8716260 0.0184013021 4.075758e-01 5.511626e-01 2 200963219 200963489 271 - 0.375 0.540 0.844
ENSG00000115942 E031 62.0613974 0.0017629844 2.388959e-06 1.827429e-05 2 200963490 200963680 191 - 1.793 1.527 -0.904