ENSG00000115935

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000272746 ENSG00000115935 HEK293_OSMI2_2hA HEK293_TMG_2hB WIPF1 protein_coding protein_coding 6.835054 6.815815 9.245926 0.5223989 0.3153609 0.4393759 0.4132884 0.0000000 0.6717680 0.00000000 0.43023344 6.0912090 0.05438750 0.00000000 0.07233333 0.07233333 0.2438394002 0.0003286594 FALSE  
ENST00000359761 ENSG00000115935 HEK293_OSMI2_2hA HEK293_TMG_2hB WIPF1 protein_coding protein_coding 6.835054 6.815815 9.245926 0.5223989 0.3153609 0.4393759 0.8802262 0.1695428 1.3790028 0.16954280 0.41844348 2.9516498 0.11823750 0.02936667 0.15083333 0.12146667 0.1513286916 0.0003286594 FALSE  
ENST00000392547 ENSG00000115935 HEK293_OSMI2_2hA HEK293_TMG_2hB WIPF1 protein_coding protein_coding 6.835054 6.815815 9.245926 0.5223989 0.3153609 0.4393759 3.9569450 4.6124356 5.6371092 0.46567419 0.02548669 0.2888593 0.57652917 0.67446667 0.61120000 -0.06326667 0.4185019811 0.0003286594 FALSE  
ENST00000409415 ENSG00000115935 HEK293_OSMI2_2hA HEK293_TMG_2hB WIPF1 protein_coding protein_coding 6.835054 6.815815 9.245926 0.5223989 0.3153609 0.4393759 0.2919296 0.5042618 0.1724059 0.05242273 0.02293890 -1.4953506 0.04875833 0.07383333 0.01870000 -0.05513333 0.0003286594 0.0003286594 FALSE  
ENST00000487291 ENSG00000115935 HEK293_OSMI2_2hA HEK293_TMG_2hB WIPF1 protein_coding processed_transcript 6.835054 6.815815 9.245926 0.5223989 0.3153609 0.4393759 0.9951617 1.3894709 1.0590665 0.26027643 0.41428272 -0.3885299 0.15386667 0.20253333 0.11166667 -0.09086667 0.4519289620 0.0003286594    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115935 E001 0.6599951 0.0208509873 2.177844e-02 5.521466e-02 2 174559572 174559573 2 - 0.000 0.400 11.569
ENSG00000115935 E002 197.0351956 0.0110205919 1.791650e-06 1.408276e-05 2 174559574 174560769 1196 - 2.143 2.421 0.928
ENSG00000115935 E003 239.4787756 0.0019243178 8.216380e-01 8.874849e-01 2 174560770 174562125 1356 - 2.366 2.395 0.097
ENSG00000115935 E004 32.1120242 0.0111179683 1.922115e-01 3.165324e-01 2 174562126 174562203 78 - 1.548 1.477 -0.243
ENSG00000115935 E005 18.9318879 0.0016071097 1.607686e-02 4.290703e-02 2 174562204 174562210 7 - 1.368 1.209 -0.558
ENSG00000115935 E006 86.1229685 0.0014108534 1.286868e-01 2.323300e-01 2 174562211 174562550 340 - 1.949 1.921 -0.093
ENSG00000115935 E007 51.9050350 0.0097986614 9.787573e-01 9.908019e-01 2 174562551 174562602 52 - 1.705 1.738 0.109
ENSG00000115935 E008 0.0000000       2 174566161 174567069 909 -      
ENSG00000115935 E009 35.4165788 0.0086422788 8.032793e-01 8.747609e-01 2 174567070 174567076 7 - 1.531 1.580 0.169
ENSG00000115935 E010 59.6258265 0.0006328494 4.794422e-01 6.178248e-01 2 174567077 174567183 107 - 1.776 1.777 0.005
ENSG00000115935 E011 64.8514119 0.0009889410 1.197513e-01 2.196200e-01 2 174567861 174568073 213 - 1.831 1.796 -0.118
ENSG00000115935 E012 0.4396707 0.0298544043 1.267657e-01 2.296474e-01 2 174568607 174568823 217 - 0.264 0.000 -13.504
ENSG00000115935 E013 0.2214452 0.0384145811 3.920884e-01   2 174570439 174570646 208 - 0.000 0.140 11.629
ENSG00000115935 E014 5.8635341 0.0029014144 2.283764e-03 8.101245e-03 2 174571169 174571675 507 - 0.579 1.005 1.705
ENSG00000115935 E015 110.1641882 0.0015143904 6.304945e-02 1.317886e-01 2 174571676 174572323 648 - 2.059 2.027 -0.108
ENSG00000115935 E016 38.5103414 0.0005996861 2.000492e-02 5.149774e-02 2 174572324 174572446 123 - 1.638 1.541 -0.330
ENSG00000115935 E017 0.1515154 0.0431200447 6.019669e-01   2 174574730 174574941 212 - 0.107 0.000 -11.847
ENSG00000115935 E018 24.4797153 0.0008139910 1.278245e-02 3.540139e-02 2 174575204 174575262 59 - 1.465 1.324 -0.488
ENSG00000115935 E019 25.7190206 0.0083910812 9.041656e-03 2.638297e-02 2 174575263 174575371 109 - 1.498 1.318 -0.622
ENSG00000115935 E020 16.8522495 0.0265262173 3.769613e-02 8.676142e-02 2 174575372 174575380 9 - 1.336 1.131 -0.726
ENSG00000115935 E021 0.1515154 0.0431200447 6.019669e-01   2 174581140 174581309 170 - 0.107 0.000 -11.847
ENSG00000115935 E022 28.3788931 0.0010183567 4.953117e-04 2.142212e-03 2 174581310 174581439 130 - 1.552 1.354 -0.680
ENSG00000115935 E023 21.4232896 0.0008873679 3.961687e-02 9.032060e-02 2 174585523 174585611 89 - 1.403 1.283 -0.416
ENSG00000115935 E024 0.0000000       2 174597601 174597858 258 -      
ENSG00000115935 E025 0.0000000       2 174598171 174598175 5 -      
ENSG00000115935 E026 0.0000000       2 174598176 174598211 36 -      
ENSG00000115935 E027 0.2934659 0.0294273002 8.706141e-01   2 174623481 174623508 28 - 0.107 0.139 0.440
ENSG00000115935 E028 0.0000000       2 174625624 174625709 86 -      
ENSG00000115935 E029 0.0000000       2 174625710 174625820 111 -      
ENSG00000115935 E030 0.0000000       2 174625821 174625856 36 -      
ENSG00000115935 E031 0.5932745 0.0286508664 8.299886e-01 8.932621e-01 2 174625857 174625960 104 - 0.193 0.245 0.437
ENSG00000115935 E032 0.4417591 0.0921597866 4.733438e-01 6.122949e-01 2 174629666 174629868 203 - 0.107 0.243 1.428
ENSG00000115935 E033 0.1472490 0.0437974682 6.018334e-01   2 174630382 174630560 179 - 0.107 0.000 -11.841
ENSG00000115935 E034 0.0000000       2 174630561 174630625 65 -      
ENSG00000115935 E035 0.0000000       2 174630626 174630696 71 -      
ENSG00000115935 E036 0.5159433 0.2610345061 7.716709e-01 8.526096e-01 2 174634518 174634605 88 - 0.193 0.142 -0.532
ENSG00000115935 E037 1.4101577 0.1078414590 7.848386e-01 8.620408e-01 2 174673267 174673816 550 - 0.326 0.405 0.462
ENSG00000115935 E038 10.2875296 0.0590760420 4.370773e-02 9.784926e-02 2 174676337 174676666 330 - 0.853 1.211 1.315
ENSG00000115935 E039 8.3156474 0.0019998138 5.856271e-03 1.823472e-02 2 174677045 174677124 80 - 0.780 1.118 1.272
ENSG00000115935 E040 21.9932139 0.0011846425 8.989720e-01 9.395534e-01 2 174682774 174682916 143 - 1.352 1.376 0.082