ENSG00000115875

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000313117 ENSG00000115875 HEK293_OSMI2_2hA HEK293_TMG_2hB SRSF7 protein_coding protein_coding 223.8172 186.9872 326.8941 18.64824 4.731578 0.805851 29.99165 21.779281 56.40932 5.1595633 3.2948789 1.3725707 0.12037500 0.11363333 0.17240000 0.05876667 7.087966e-02 6.85909e-12 FALSE  
ENST00000409276 ENSG00000115875 HEK293_OSMI2_2hA HEK293_TMG_2hB SRSF7 protein_coding protein_coding 223.8172 186.9872 326.8941 18.64824 4.731578 0.805851 97.75178 91.622701 129.05129 10.0873116 3.8437228 0.4941219 0.44742500 0.48900000 0.39510000 -0.09390000 2.656170e-03 6.85909e-12 FALSE  
ENST00000443213 ENSG00000115875 HEK293_OSMI2_2hA HEK293_TMG_2hB SRSF7 protein_coding nonsense_mediated_decay 223.8172 186.9872 326.8941 18.64824 4.731578 0.805851 31.48543 13.818638 39.92394 1.0222384 1.5821817 1.5299563 0.14190833 0.07546667 0.12230000 0.04683333 3.178427e-02 6.85909e-12 TRUE  
ENST00000452806 ENSG00000115875 HEK293_OSMI2_2hA HEK293_TMG_2hB SRSF7 protein_coding protein_coding 223.8172 186.9872 326.8941 18.64824 4.731578 0.805851 12.17787 17.016523 14.86993 2.2343327 0.9285208 -0.1944157 0.05993750 0.09096667 0.04543333 -0.04553333 5.325272e-05 6.85909e-12 FALSE  
MSTRG.18255.13 ENSG00000115875 HEK293_OSMI2_2hA HEK293_TMG_2hB SRSF7 protein_coding   223.8172 186.9872 326.8941 18.64824 4.731578 0.805851 18.54398 8.372296 41.95727 0.7736188 3.0725086 2.3238473 0.07133333 0.04516667 0.12813333 0.08296667 6.859090e-12 6.85909e-12 FALSE  
MSTRG.18255.9 ENSG00000115875 HEK293_OSMI2_2hA HEK293_TMG_2hB SRSF7 protein_coding   223.8172 186.9872 326.8941 18.64824 4.731578 0.805851 20.99944 26.046943 23.81862 1.7513005 2.2858471 -0.1289726 0.10165417 0.14016667 0.07273333 -0.06743333 2.097143e-06 6.85909e-12 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115875 E001 4.420925 1.585206e-02 8.751531e-03 2.566329e-02 2 38743599 38743600 2 - 0.544 0.913 1.522
ENSG00000115875 E002 768.391300 1.326891e-02 1.183322e-03 4.584860e-03 2 38743601 38744452 852 - 2.968 2.770 -0.656
ENSG00000115875 E003 389.608511 7.380159e-03 2.359401e-11 4.627136e-10 2 38744453 38744716 264 - 2.718 2.387 -1.103
ENSG00000115875 E004 231.152179 6.853270e-03 7.482382e-08 7.787259e-07 2 38744717 38744892 176 - 2.477 2.201 -0.920
ENSG00000115875 E005 58.033458 3.268353e-03 5.027277e-01 6.387420e-01 2 38744893 38744894 2 - 1.769 1.787 0.058
ENSG00000115875 E006 59.507052 4.636992e-03 2.716885e-01 4.104543e-01 2 38744895 38744896 2 - 1.767 1.811 0.148
ENSG00000115875 E007 74.168456 2.949361e-03 2.624818e-02 6.445168e-02 2 38744897 38744917 21 - 1.839 1.929 0.301
ENSG00000115875 E008 947.691521 1.244790e-03 1.714749e-06 1.353502e-05 2 38744918 38745052 135 - 2.944 3.015 0.237
ENSG00000115875 E009 1727.927465 3.179299e-04 8.190986e-17 3.563163e-15 2 38745053 38745187 135 - 3.206 3.277 0.238
ENSG00000115875 E010 1291.109834 8.398923e-05 2.157752e-28 3.161483e-26 2 38746144 38746179 36 - 3.070 3.162 0.306
ENSG00000115875 E011 1530.388160 1.698964e-04 1.930528e-18 1.026669e-16 2 38746694 38746747 54 - 3.155 3.223 0.227
ENSG00000115875 E012 81.589206 2.515080e-03 2.637413e-32 5.203208e-30 2 38746748 38747044 297 - 2.112 1.454 -2.225
ENSG00000115875 E013 42.320790 6.220463e-02 1.762344e-05 1.106583e-04 2 38747062 38747130 69 - 1.825 1.202 -2.141
ENSG00000115875 E014 937.071883 3.051092e-04 9.126506e-11 1.621637e-09 2 38748047 38748055 9 - 2.943 3.010 0.221
ENSG00000115875 E015 1041.836504 4.946455e-04 5.896253e-07 5.145221e-06 2 38748056 38748079 24 - 2.997 3.046 0.164
ENSG00000115875 E016 1567.199052 1.034527e-04 7.390852e-12 1.571817e-10 2 38748080 38748157 78 - 3.178 3.221 0.143
ENSG00000115875 E017 1838.028358 9.451457e-05 6.770616e-04 2.815163e-03 2 38748579 38748653 75 - 3.264 3.272 0.025
ENSG00000115875 E018 237.231883 1.722383e-02 1.436671e-02 3.906058e-02 2 38748654 38748897 244 - 2.458 2.258 -0.667
ENSG00000115875 E019 355.587221 1.026673e-02 1.606417e-03 5.981933e-03 2 38748898 38749173 276 - 2.635 2.430 -0.684
ENSG00000115875 E020 203.552341 9.368478e-03 5.407097e-05 3.020993e-04 2 38749174 38749239 66 - 2.410 2.158 -0.843
ENSG00000115875 E021 261.059852 5.572499e-03 3.069391e-04 1.407686e-03 2 38749240 38749346 107 - 2.496 2.308 -0.628
ENSG00000115875 E022 148.469535 6.751510e-03 7.710997e-08 8.003645e-07 2 38749347 38749528 182 - 2.292 1.983 -1.034
ENSG00000115875 E023 2750.216452 1.793089e-04 3.842211e-01 5.283900e-01 2 38749529 38749705 177 - 3.450 3.433 -0.058
ENSG00000115875 E024 2807.566760 2.806921e-04 6.811642e-05 3.710521e-04 2 38750014 38750194 181 - 3.480 3.414 -0.217
ENSG00000115875 E025 7.002767 4.268786e-03 3.389908e-04 1.536456e-03 2 38750824 38751228 405 - 1.063 0.565 -1.984
ENSG00000115875 E026 1847.894409 6.042659e-04 1.169171e-19 7.156573e-18 2 38751229 38751494 266 - 3.334 3.179 -0.516