ENSG00000115827

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339506 ENSG00000115827 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF17 protein_coding protein_coding 5.431007 1.558293 9.616098 0.1212327 0.251718 2.617756 0.23228803 0.00000000 0.52033021 0.00000000 0.14119108 5.728819 0.04492500 0.00000000 0.05343333 0.05343333 0.02445042 0.02445042 FALSE  
ENST00000375255 ENSG00000115827 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF17 protein_coding protein_coding 5.431007 1.558293 9.616098 0.1212327 0.251718 2.617756 0.56935521 0.00000000 0.98521459 0.00000000 0.51902239 6.636936 0.08940000 0.00000000 0.10396667 0.10396667 0.45817986 0.02445042 FALSE  
ENST00000431110 ENSG00000115827 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF17 protein_coding protein_coding 5.431007 1.558293 9.616098 0.1212327 0.251718 2.617756 0.05158701 0.17754982 0.05590371 0.17754982 0.02941624 -1.508842 0.01833333 0.12083333 0.00590000 -0.11493333 0.86422604 0.02445042 FALSE  
ENST00000436317 ENSG00000115827 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF17 protein_coding nonsense_mediated_decay 5.431007 1.558293 9.616098 0.1212327 0.251718 2.617756 0.50128413 0.03699591 1.05249601 0.03699591 0.20263920 4.498778 0.07486667 0.02630000 0.10930000 0.08300000 0.06393958 0.02445042 TRUE  
ENST00000468592 ENSG00000115827 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF17 protein_coding processed_transcript 5.431007 1.558293 9.616098 0.1212327 0.251718 2.617756 1.99827992 0.53903297 4.14094422 0.27223658 0.16094322 2.918475 0.30721250 0.33793333 0.43036667 0.09243333 0.83258005 0.02445042 FALSE  
ENST00000493106 ENSG00000115827 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF17 protein_coding retained_intron 5.431007 1.558293 9.616098 0.1212327 0.251718 2.617756 0.42476550 0.03530100 0.71865364 0.03530100 0.09464507 4.007618 0.06688333 0.02403333 0.07523333 0.05120000 0.14332863 0.02445042    
ENST00000498486 ENSG00000115827 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF17 protein_coding retained_intron 5.431007 1.558293 9.616098 0.1212327 0.251718 2.617756 0.47583232 0.08627109 0.56210227 0.04337507 0.08281074 2.571099 0.12075417 0.05503333 0.05813333 0.00310000 0.97963523 0.02445042    
ENST00000539783 ENSG00000115827 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF17 protein_coding protein_coding 5.431007 1.558293 9.616098 0.1212327 0.251718 2.617756 0.70327932 0.34129122 1.32046207 0.15396198 0.30925191 1.921188 0.13873750 0.21313333 0.13690000 -0.07623333 0.81332025 0.02445042 FALSE  
MSTRG.19480.5 ENSG00000115827 HEK293_OSMI2_2hA HEK293_TMG_2hB DCAF17 protein_coding   5.431007 1.558293 9.616098 0.1212327 0.251718 2.617756 0.11611072 0.26192651 0.00000000 0.26192651 0.00000000 -4.765145 0.04653333 0.17826667 0.00000000 -0.17826667 0.55153142 0.02445042 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115827 E001 0.4513240 0.1587097083 0.4469637462 0.588397851 2 171434166 171434216 51 + 0.098 0.263 1.723
ENSG00000115827 E002 0.7437457 0.0156648541 0.8077504508 0.877838026 2 171434217 171434225 9 + 0.177 0.265 0.738
ENSG00000115827 E003 4.7985258 0.0033888808 0.5936626602 0.716034952 2 171434226 171434250 25 + 0.656 0.640 -0.068
ENSG00000115827 E004 6.4529478 0.0025114939 0.4319064654 0.574400715 2 171434251 171434270 20 + 0.762 0.716 -0.187
ENSG00000115827 E005 9.7703613 0.0211368732 0.6645902474 0.772402080 2 171434271 171434510 240 + 0.906 0.931 0.094
ENSG00000115827 E006 9.5319616 0.0191953694 0.7725716582 0.853200246 2 171434511 171434656 146 + 0.878 1.009 0.492
ENSG00000115827 E007 5.2317375 0.0033565140 0.4693422926 0.608589190 2 171434657 171434663 7 + 0.643 0.838 0.792
ENSG00000115827 E008 8.2825015 0.0285510129 0.6115154347 0.730622936 2 171434664 171434701 38 + 0.815 0.974 0.605
ENSG00000115827 E009 6.8045870 0.0285643876 0.4415246023 0.583168286 2 171434702 171434703 2 + 0.733 0.934 0.785
ENSG00000115827 E010 0.4482035 0.0274881822 1.0000000000 1.000000000 2 171434704 171434997 294 + 0.139 0.000 -24.206
ENSG00000115827 E011 24.6639850 0.0008066945 0.3980139578 0.541747257 2 171435083 171435186 104 + 1.273 1.290 0.059
ENSG00000115827 E012 0.1482932 0.0411597534 0.0718651371   2 171443137 171443522 386 + 0.000 0.265 27.739
ENSG00000115827 E013 28.0634375 0.0006892939 0.4927875096 0.629918797 2 171443523 171443613 91 + 1.323 1.359 0.127
ENSG00000115827 E014 3.7538255 0.0045053650 0.5872563271 0.710574567 2 171447386 171447503 118 + 0.576 0.547 -0.135
ENSG00000115827 E015 34.4741267 0.0006538676 0.8536694117 0.909463077 2 171448681 171448817 137 + 1.401 1.483 0.283
ENSG00000115827 E016 29.1537277 0.0006559352 0.7715954420 0.852591266 2 171449879 171449957 79 + 1.333 1.405 0.248
ENSG00000115827 E017 1.6294419 0.0087784722 0.3454865193 0.489581917 2 171449958 171450075 118 + 0.303 0.546 1.322
ENSG00000115827 E018 0.1482932 0.0411597534 0.0718651371   2 171453122 171453123 2 + 0.000 0.265 27.739
ENSG00000115827 E019 30.1279132 0.0007421896 0.0083590846 0.024687651 2 171453124 171453213 90 + 1.376 1.230 -0.513
ENSG00000115827 E020 30.0581011 0.0160238466 0.3154082597 0.458173449 2 171457971 171458075 105 + 1.358 1.343 -0.053
ENSG00000115827 E021 11.2433076 0.0019855991 0.0999632197 0.190436146 2 171458372 171458477 106 + 0.981 0.838 -0.541
ENSG00000115827 E022 32.7239115 0.0079452262 0.3127523605 0.455278903 2 171468888 171468976 89 + 1.390 1.390 0.000
ENSG00000115827 E023 28.5593005 0.0007220485 0.0331153429 0.078037645 2 171468977 171469030 54 + 1.350 1.251 -0.348
ENSG00000115827 E024 0.5954526 0.0183636786 0.6088833266 0.728477676 2 171472870 171472955 86 + 0.177 0.000 -24.616
ENSG00000115827 E025 24.8806804 0.0029046545 0.0225531180 0.056831121 2 171473866 171473975 110 + 1.299 1.160 -0.490
ENSG00000115827 E026 3.6319223 0.0070297363 0.0725374719 0.147573093 2 171473976 171474384 409 + 0.591 0.265 -1.784
ENSG00000115827 E027 27.1335498 0.0007518320 0.0052734972 0.016676096 2 171476860 171476950 91 + 1.338 1.160 -0.627
ENSG00000115827 E028 30.7717181 0.0024744061 0.0007642935 0.003129850 2 171477987 171478070 84 + 1.395 1.160 -0.823
ENSG00000115827 E029 5.5619531 0.0033676266 0.3818201142 0.526091794 2 171479656 171480037 382 + 0.712 0.640 -0.305
ENSG00000115827 E030 40.4617665 0.0005868474 0.0014756712 0.005558545 2 171480038 171480193 156 + 1.501 1.343 -0.548
ENSG00000115827 E031 437.4040413 0.0158569269 0.0003595324 0.001616987 2 171480974 171485052 4079 + 2.461 2.669 0.690