ENSG00000115825

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000234179 ENSG00000115825 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKD3 protein_coding protein_coding 16.498 4.129301 25.78528 0.1173197 0.6215957 2.639648 6.221711 1.3430834 9.8497287 0.78016689 1.0887431 2.865297 0.3662583 0.33410000 0.38043333 0.04633333 0.87298409 7.738993e-05 FALSE TRUE
ENST00000379066 ENSG00000115825 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKD3 protein_coding protein_coding 16.498 4.129301 25.78528 0.1173197 0.6215957 2.639648 1.425653 1.9933345 0.7915084 0.93030481 0.7915084 -1.321614 0.1922208 0.47350000 0.03206667 -0.44143333 0.06063874 7.738993e-05 FALSE TRUE
MSTRG.18232.1 ENSG00000115825 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKD3 protein_coding   16.498 4.129301 25.78528 0.1173197 0.6215957 2.639648 2.408625 0.1513387 4.5910171 0.08162951 0.3540593 4.833788 0.1146250 0.03776667 0.17830000 0.14053333 0.01054726 7.738993e-05 FALSE TRUE
MSTRG.18232.4 ENSG00000115825 HEK293_OSMI2_2hA HEK293_TMG_2hB PRKD3 protein_coding   16.498 4.129301 25.78528 0.1173197 0.6215957 2.639648 4.146969 0.1458931 5.3410682 0.14589314 0.5661584 5.101198 0.1954958 0.03616667 0.20636667 0.17020000 0.08995578 7.738993e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115825 E001 687.2854089 0.0026304907 1.141018e-09 1.673602e-08 2 37250502 37253218 2717 - 2.706 2.874 0.561
ENSG00000115825 E002 78.4066646 0.0003923965 4.535487e-03 1.464196e-02 2 37253219 37253246 28 - 1.774 1.926 0.513
ENSG00000115825 E003 94.2839582 0.0003351946 2.088502e-03 7.497686e-03 2 37253247 37253307 61 - 1.854 2.005 0.507
ENSG00000115825 E004 62.8649007 0.0004684925 4.970056e-03 1.584615e-02 2 37253308 37253324 17 - 1.678 1.843 0.558
ENSG00000115825 E005 52.9984622 0.0006162668 5.958122e-03 1.849801e-02 2 37253325 37253325 1 - 1.603 1.777 0.590
ENSG00000115825 E006 65.0237081 0.0003867882 1.988156e-02 5.123724e-02 2 37253326 37253350 25 - 1.700 1.839 0.470
ENSG00000115825 E007 83.9811018 0.0003055004 1.376927e-02 3.769793e-02 2 37254204 37254289 86 - 1.809 1.941 0.443
ENSG00000115825 E008 70.3369728 0.0028265692 1.447104e-02 3.929444e-02 2 37256662 37256697 36 - 1.725 1.878 0.515
ENSG00000115825 E009 139.5061257 0.0044854849 2.916351e-02 7.031511e-02 2 37256698 37256929 232 - 2.027 2.149 0.408
ENSG00000115825 E010 77.9028287 0.0009279463 5.820930e-02 1.235611e-01 2 37259583 37259681 99 - 1.781 1.893 0.378
ENSG00000115825 E011 104.8164257 0.0013400382 2.016949e-01 3.282920e-01 2 37260223 37260355 133 - 1.917 1.993 0.257
ENSG00000115825 E012 70.9735868 0.0004127682 7.575986e-02 1.527191e-01 2 37260356 37260384 29 - 1.743 1.852 0.366
ENSG00000115825 E013 100.7413927 0.0004673689 3.689568e-02 8.526703e-02 2 37267430 37267536 107 - 1.894 2.002 0.364
ENSG00000115825 E014 3.6151093 0.0042997147 4.368090e-01 5.788362e-01 2 37267565 37268300 736 - 0.620 0.492 -0.593
ENSG00000115825 E015 1.4976081 0.1118251021 8.775409e-01 9.253296e-01 2 37268301 37268372 72 - 0.343 0.379 0.212
ENSG00000115825 E016 5.8223745 0.0111297456 6.336493e-02 1.322962e-01 2 37268373 37269614 1242 - 0.809 0.492 -1.372
ENSG00000115825 E017 77.5928311 0.0005257458 6.158109e-02 1.292923e-01 2 37269615 37269687 73 - 1.783 1.893 0.370
ENSG00000115825 E018 58.1510900 0.0028973628 1.651681e-01 2.819050e-01 2 37272380 37272429 50 - 1.659 1.762 0.350
ENSG00000115825 E019 35.3553300 0.0046150016 2.673883e-01 4.056985e-01 2 37272430 37272432 3 - 1.446 1.549 0.355
ENSG00000115825 E020 146.2872086 0.0002779874 9.201327e-01 9.535542e-01 2 37274421 37274697 277 - 2.073 2.090 0.056
ENSG00000115825 E021 85.9582558 0.0010173497 1.606624e-01 2.759872e-01 2 37275767 37275844 78 - 1.857 1.807 -0.169
ENSG00000115825 E022 112.0662523 0.0003077297 1.100409e-03 4.304606e-03 2 37277866 37277989 124 - 1.984 1.861 -0.416
ENSG00000115825 E023 0.7728905 0.0144744566 9.410394e-01 9.669214e-01 2 37277990 37279390 1401 - 0.205 0.231 0.215
ENSG00000115825 E024 132.5037289 0.0088256608 7.796056e-04 3.186012e-03 2 37279746 37279929 184 - 2.066 1.877 -0.634
ENSG00000115825 E025 0.0000000       2 37282306 37282541 236 -      
ENSG00000115825 E026 78.0630107 0.0003716852 1.139919e-04 5.860995e-04 2 37282542 37282619 78 - 1.839 1.648 -0.645
ENSG00000115825 E027 71.1477426 0.0004173047 2.641221e-06 2.001566e-05 2 37286177 37286231 55 - 1.807 1.549 -0.877
ENSG00000115825 E028 102.7041172 0.0026089864 1.020846e-05 6.771814e-05 2 37286232 37286369 138 - 1.961 1.741 -0.739
ENSG00000115825 E029 88.0739849 0.0047251670 1.109208e-03 4.333956e-03 2 37289356 37289513 158 - 1.892 1.711 -0.610
ENSG00000115825 E030 99.7676755 0.0012718180 2.504394e-08 2.863825e-07 2 37290868 37290999 132 - 1.957 1.681 -0.930
ENSG00000115825 E031 1.4298538 0.0114047627 7.737205e-01 8.540168e-01 2 37292988 37293132 145 - 0.313 0.381 0.409
ENSG00000115825 E032 99.3538197 0.0002739867 2.409980e-09 3.328207e-08 2 37293133 37293271 139 - 1.956 1.675 -0.950
ENSG00000115825 E033 78.2820954 0.0003626048 5.293655e-05 2.964694e-04 2 37316237 37316451 215 - 1.842 1.641 -0.681
ENSG00000115825 E034 93.8060484 0.0037514034 9.693216e-05 5.076719e-04 2 37316452 37316813 362 - 1.921 1.712 -0.704
ENSG00000115825 E035 104.8236785 0.0003064433 4.097944e-12 9.086413e-11 2 37316814 37317179 366 - 1.986 1.655 -1.116
ENSG00000115825 E036 16.7801166 0.0120655249 4.422605e-03 1.432539e-02 2 37317787 37317899 113 - 1.219 0.863 -1.304
ENSG00000115825 E037 13.7468916 0.0012724481 1.820193e-01 3.037482e-01 2 37324198 37324680 483 - 1.112 0.974 -0.504
ENSG00000115825 E038 40.1534486 0.0006665338 3.586567e-07 3.265713e-06 2 37324681 37324833 153 - 1.585 1.177 -1.417