ENSG00000115816

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000234170 ENSG00000115816 HEK293_OSMI2_2hA HEK293_TMG_2hB CEBPZ protein_coding protein_coding 31.28682 11.14646 50.79295 1.240994 1.286075 2.187033 25.879338 4.716748 47.635256 0.2887268 1.7487369 3.333413 0.71472500 0.4342667 0.93803333 0.5037667 0.00216955 0.00216955 FALSE TRUE
ENST00000489306 ENSG00000115816 HEK293_OSMI2_2hA HEK293_TMG_2hB CEBPZ protein_coding retained_intron 31.28682 11.14646 50.79295 1.240994 1.286075 2.187033 3.712327 4.595590 1.871960 0.7366513 0.9396896 -1.291150 0.19694583 0.4088000 0.03640000 -0.3724000 0.08556507 0.00216955 FALSE FALSE
MSTRG.18229.4 ENSG00000115816 HEK293_OSMI2_2hA HEK293_TMG_2hB CEBPZ protein_coding   31.28682 11.14646 50.79295 1.240994 1.286075 2.187033 1.494330 1.789820 1.077312 0.5785975 0.7339458 -0.727086 0.07857917 0.1533333 0.02143333 -0.1319000 0.14852713 0.00216955 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115816 E001 52.9196120 0.0271113533 4.580652e-03 1.476613e-02 2 37201612 37201783 172 - 1.544 1.838 1.000
ENSG00000115816 E002 146.4986804 0.0002603960 2.446155e-08 2.802811e-07 2 37201784 37201903 120 - 2.000 2.204 0.683
ENSG00000115816 E003 185.5819281 0.0002137566 3.033091e-06 2.266617e-05 2 37202784 37202865 82 - 2.112 2.267 0.519
ENSG00000115816 E004 1.0371996 0.0266219494 3.225750e-01 4.658763e-01 2 37202866 37202949 84 - 0.283 0.000 -12.635
ENSG00000115816 E005 150.6817726 0.0002387555 3.293700e-06 2.444111e-05 2 37202950 37203008 59 - 2.018 2.189 0.571
ENSG00000115816 E006 5.5497325 0.0029634191 9.800238e-01 9.915435e-01 2 37203009 37204880 1872 - 0.705 0.702 -0.010
ENSG00000115816 E007 0.6600838 0.0409187002 9.118421e-02 1.769845e-01 2 37206041 37206105 65 - 0.101 0.418 2.623
ENSG00000115816 E008 215.4520276 0.0002156244 1.000312e-08 1.233603e-07 2 37210999 37211082 84 - 2.172 2.347 0.585
ENSG00000115816 E009 387.1431518 0.0001644064 2.292019e-06 1.759741e-05 2 37211843 37212039 197 - 2.438 2.549 0.369
ENSG00000115816 E010 3.7341439 0.0042479264 7.844213e-01 8.617054e-01 2 37212040 37212108 69 - 0.575 0.626 0.228
ENSG00000115816 E011 211.1746425 0.0001869611 1.861536e-01 3.089222e-01 2 37212335 37212392 58 - 2.189 2.234 0.150
ENSG00000115816 E012 231.7429962 0.0001693577 5.400648e-03 1.701711e-02 2 37213864 37213961 98 - 2.221 2.307 0.288
ENSG00000115816 E013 162.0775908 0.0006625026 7.476928e-03 2.245354e-02 2 37214886 37214952 67 - 2.063 2.166 0.343
ENSG00000115816 E014 154.6873506 0.0009881841 4.979516e-03 1.587337e-02 2 37216140 37216208 69 - 2.041 2.153 0.375
ENSG00000115816 E015 169.8235285 0.0026700193 7.001895e-02 1.434010e-01 2 37216316 37216418 103 - 2.088 2.168 0.269
ENSG00000115816 E016 132.6603200 0.0002764372 2.001032e-01 3.263758e-01 2 37216984 37217037 54 - 2.003 1.950 -0.180
ENSG00000115816 E017 175.2711763 0.0002008107 1.145496e-01 2.121856e-01 2 37220385 37220473 89 - 2.124 2.066 -0.193
ENSG00000115816 E018 263.1768909 0.0004491267 9.835282e-02 1.880148e-01 2 37222380 37222563 184 - 2.299 2.248 -0.168
ENSG00000115816 E019 296.6712114 0.0001977982 4.395080e-04 1.926281e-03 2 37223170 37223401 232 - 2.358 2.256 -0.341
ENSG00000115816 E020 689.9798352 0.0002003029 9.248193e-24 8.925330e-22 2 37227544 37228607 1064 - 2.736 2.535 -0.669
ENSG00000115816 E021 341.7353775 0.0003520057 2.689013e-15 9.620878e-14 2 37228608 37229036 429 - 2.436 2.198 -0.796
ENSG00000115816 E022 0.1817044 0.0412996025 5.901762e-02   2 37231273 37231411 139 - 0.000 0.257 12.317
ENSG00000115816 E023 187.8129146 0.0002375487 1.605766e-10 2.736171e-09 2 37231412 37231609 198 - 2.180 1.921 -0.868