ENSG00000115761

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381685 ENSG00000115761 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL10 protein_coding protein_coding 27.46989 15.53492 42.16887 0.6455292 1.431891 1.440078 5.228068 2.168765 8.690368 0.1159393 0.1338693 1.997566 0.1796917 0.1401333 0.2064000 0.06626667 0.005378242 0.003985177 FALSE  
ENST00000695475 ENSG00000115761 HEK293_OSMI2_2hA HEK293_TMG_2hB NOL10 protein_coding nonsense_mediated_decay 27.46989 15.53492 42.16887 0.6455292 1.431891 1.440078 19.541397 11.789631 29.609960 0.5210781 1.4456669 1.327828 0.7110708 0.7587667 0.7014333 -0.05733333 0.106926538 0.003985177 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115761 E001 11.2152185 0.0140079765 8.945724e-10 1.338129e-08 2 10562347 10562976 630 - 0.707 1.409 2.592
ENSG00000115761 E002 38.5241888 0.0059165515 2.623870e-01 4.001761e-01 2 10568297 10570753 2457 - 1.589 1.526 -0.216
ENSG00000115761 E003 0.9964121 0.1233966231 8.059845e-01 8.766699e-01 2 10570754 10570765 12 - 0.260 0.311 0.354
ENSG00000115761 E004 0.9964121 0.1233966231 8.059845e-01 8.766699e-01 2 10570766 10570767 2 - 0.260 0.311 0.354
ENSG00000115761 E005 4.4211798 0.0037485298 7.253004e-01 8.186140e-01 2 10570768 10570818 51 - 0.689 0.753 0.263
ENSG00000115761 E006 13.1474746 0.0015849031 8.149815e-02 1.618999e-01 2 10570819 10570884 66 - 1.066 1.245 0.639
ENSG00000115761 E007 71.0687893 0.0003753264 8.783090e-02 1.718350e-01 2 10570885 10571643 759 - 1.799 1.890 0.306
ENSG00000115761 E008 24.0079432 0.0008125036 3.636079e-02 8.427010e-02 2 10571644 10571669 26 - 1.310 1.477 0.578
ENSG00000115761 E009 28.7475648 0.0009563794 3.065793e-04 1.406161e-03 2 10571670 10571679 10 - 1.352 1.606 0.873
ENSG00000115761 E010 300.6549790 0.0124185245 1.659594e-03 6.152742e-03 2 10571680 10572036 357 - 2.377 2.575 0.661
ENSG00000115761 E011 344.3402988 0.0031975393 2.282547e-05 1.396125e-04 2 10572037 10572190 154 - 2.455 2.609 0.514
ENSG00000115761 E012 5.0971728 0.0038101679 8.202102e-01 8.865694e-01 2 10572191 10574965 2775 - 0.771 0.753 -0.075
ENSG00000115761 E013 6.3657689 0.0040332709 1.841306e-01 3.064078e-01 2 10574966 10577635 2670 - 0.786 0.967 0.695
ENSG00000115761 E014 275.7770675 0.0004850540 4.627863e-06 3.320462e-05 2 10577636 10577738 103 - 2.372 2.496 0.415
ENSG00000115761 E015 443.2102574 0.0011412082 1.920147e-04 9.296825e-04 2 10589043 10589290 248 - 2.586 2.685 0.329
ENSG00000115761 E016 3.6138459 0.0251638798 3.512982e-01 4.955206e-01 2 10589291 10589577 287 - 0.587 0.752 0.699
ENSG00000115761 E017 285.2359044 0.0001693767 2.633911e-03 9.172041e-03 2 10589578 10589751 174 - 2.401 2.483 0.274
ENSG00000115761 E018 195.0131530 0.0002287533 1.728496e-04 8.475033e-04 2 10600853 10600942 90 - 2.223 2.339 0.387
ENSG00000115761 E019 199.7873245 0.0002100017 1.048421e-01 1.978625e-01 2 10602776 10602874 99 - 2.255 2.314 0.196
ENSG00000115761 E020 184.8162155 0.0005642148 7.732036e-01 8.536444e-01 2 10603078 10603157 80 - 2.237 2.243 0.021
ENSG00000115761 E021 221.6642445 0.0027482704 4.947380e-01 6.316524e-01 2 10607185 10607311 127 - 2.322 2.312 -0.035
ENSG00000115761 E022 0.2934659 0.0288572159 5.138832e-01   2 10607312 10608171 860 - 0.081 0.181 1.338
ENSG00000115761 E023 1.7058136 0.1086524143 2.228130e-01 3.537296e-01 2 10608172 10609388 1217 - 0.306 0.558 1.352
ENSG00000115761 E024 0.0000000       2 10612946 10612996 51 -      
ENSG00000115761 E025 1.2295251 0.1568665364 6.451615e-01 7.573271e-01 2 10618609 10620384 1776 - 0.307 0.403 0.578
ENSG00000115761 E026 2.9579294 0.1277577906 8.396296e-01 8.998212e-01 2 10620385 10621159 775 - 0.587 0.602 0.067
ENSG00000115761 E027 0.4407149 0.0214895031 8.728309e-01 9.222367e-01 2 10621160 10622015 856 - 0.149 0.181 0.339
ENSG00000115761 E028 0.7353267 0.0639873156 6.700148e-01 7.766122e-01 2 10622016 10622016 1 - 0.259 0.181 -0.664
ENSG00000115761 E029 1.5865781 0.0096792058 1.714925e-01 2.901428e-01 2 10622017 10622150 134 - 0.306 0.555 1.339
ENSG00000115761 E030 4.1189130 0.0966295255 3.212929e-03 1.089360e-02 2 10633805 10634558 754 - 0.420 1.001 2.469
ENSG00000115761 E031 159.6543431 0.0042329367 5.674739e-01 6.942645e-01 2 10644320 10644372 53 - 2.180 2.167 -0.043
ENSG00000115761 E032 156.0703293 0.0043568115 9.356604e-01 9.635161e-01 2 10654481 10654547 67 - 2.164 2.173 0.029
ENSG00000115761 E033 0.4751703 0.0205969038 1.820924e-01 3.038354e-01 2 10654548 10655180 633 - 0.081 0.309 2.339
ENSG00000115761 E034 212.2205453 0.0002249543 1.618749e-01 2.775770e-01 2 10657742 10657891 150 - 2.309 2.288 -0.072
ENSG00000115761 E035 151.7812220 0.0012285090 1.794653e-02 4.702079e-02 2 10659172 10659250 79 - 2.180 2.112 -0.225
ENSG00000115761 E036 179.4168339 0.0002489922 2.924034e-04 1.348859e-03 2 10662959 10663044 86 - 2.258 2.167 -0.304
ENSG00000115761 E037 179.5379769 0.0002168679 5.504869e-08 5.878698e-07 2 10667218 10667278 61 - 2.271 2.124 -0.492
ENSG00000115761 E038 164.5875565 0.0002468511 2.312906e-08 2.663990e-07 2 10668658 10668723 66 - 2.236 2.076 -0.538
ENSG00000115761 E039 192.9836500 0.0004146868 1.107285e-08 1.353978e-07 2 10671554 10671690 137 - 2.303 2.147 -0.521
ENSG00000115761 E040 4.2980566 0.0969030930 8.278511e-01 8.917909e-01 2 10671691 10672867 1177 - 0.690 0.746 0.232
ENSG00000115761 E041 0.9233738 0.0137925799 8.215771e-01 8.874738e-01 2 10672868 10672986 119 - 0.260 0.309 0.339
ENSG00000115761 E042 0.8920389 0.0138864694 8.265430e-01 8.908629e-01 2 10672987 10673321 335 - 0.260 0.308 0.338
ENSG00000115761 E043 0.9254501 0.0132753898 8.227899e-01 8.882536e-01 2 10673322 10673519 198 - 0.260 0.309 0.339
ENSG00000115761 E044 105.4631995 0.0007677479 1.008268e-05 6.693182e-05 2 10673520 10673557 38 - 2.045 1.879 -0.558
ENSG00000115761 E045 146.4707357 0.0028056534 5.456834e-05 3.045638e-04 2 10675794 10675871 78 - 2.184 2.028 -0.523
ENSG00000115761 E046 160.7533579 0.0025551255 3.031523e-07 2.802757e-06 2 10681971 10682069 99 - 2.234 2.041 -0.646
ENSG00000115761 E047 106.8625299 0.0034175008 3.394773e-09 4.560556e-08 2 10684567 10684612 46 - 2.077 1.797 -0.942
ENSG00000115761 E048 20.9845997 0.0226178813 2.326259e-01 3.655677e-01 2 10685937 10686052 116 - 1.351 1.232 -0.419
ENSG00000115761 E049 133.7249741 0.0039023112 1.474848e-06 1.181343e-05 2 10689796 10689987 192 - 2.158 1.945 -0.712