ENSG00000115758

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000446285 ENSG00000115758 HEK293_OSMI2_2hA HEK293_TMG_2hB ODC1 protein_coding processed_transcript 321.6135 337.743 380.7931 69.90645 7.477152 0.1730765 33.71791 15.28445 67.34243 4.762099 3.738610 2.13872129 0.09874167 0.04766667 0.1766667 0.1290000 0.0005525721 0.0001741181   FALSE
MSTRG.17947.5 ENSG00000115758 HEK293_OSMI2_2hA HEK293_TMG_2hB ODC1 protein_coding   321.6135 337.743 380.7931 69.90645 7.477152 0.1730765 265.89645 302.84361 286.24603 64.950068 6.843476 -0.08131452 0.83626667 0.89490000 0.7516667 -0.1432333 0.0001741181 0.0001741181 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115758 E001 23.0434788 0.0101132354 4.760986e-01 6.147915e-01 2 10439968 10440386 419 - 1.341 1.420 0.276
ENSG00000115758 E002 68.6602054 0.0121227458 7.297851e-06 5.002192e-05 2 10440387 10440414 28 - 1.617 1.966 1.177
ENSG00000115758 E003 86.7257820 0.0134613521 1.666017e-02 4.419185e-02 2 10440415 10440416 2 - 1.825 2.020 0.656
ENSG00000115758 E004 1344.1512458 0.0022911264 1.233670e-21 9.439217e-20 2 10440417 10440600 184 - 2.962 3.220 0.855
ENSG00000115758 E005 3864.8395251 0.0011760152 2.593138e-18 1.357078e-16 2 10440601 10440868 268 - 3.490 3.644 0.511
ENSG00000115758 E006 3959.9519615 0.0015059972 7.959367e-05 4.259423e-04 2 10441509 10441723 215 - 3.547 3.627 0.266
ENSG00000115758 E007 2653.7750229 0.0007328239 2.717491e-04 1.264760e-03 2 10441817 10441929 113 - 3.387 3.449 0.208
ENSG00000115758 E008 3003.9727273 0.0002778942 3.780999e-02 8.698333e-02 2 10442012 10442174 163 - 3.460 3.495 0.116
ENSG00000115758 E009 2220.0639516 0.0002576287 6.389200e-01 7.524522e-01 2 10443230 10443313 84 - 3.344 3.354 0.035
ENSG00000115758 E010 2302.4305283 0.0001276999 3.096489e-02 7.384727e-02 2 10443490 10443571 82 - 3.368 3.366 -0.007
ENSG00000115758 E011 3120.3823840 0.0002028392 5.496324e-04 2.345449e-03 2 10443702 10443836 135 - 3.507 3.489 -0.060
ENSG00000115758 E012 3409.6241881 0.0006505932 5.811351e-02 1.233990e-01 2 10444095 10444267 173 - 3.543 3.523 -0.065
ENSG00000115758 E013 2120.5386703 0.0006255099 7.713513e-03 2.305911e-02 2 10444474 10444543 70 - 3.344 3.313 -0.102
ENSG00000115758 E014 1262.5897455 0.0002273740 3.055498e-07 2.822169e-06 2 10444544 10444547 4 - 3.131 3.084 -0.154
ENSG00000115758 E015 2266.1115129 0.0003172416 3.894127e-06 2.839806e-05 2 10444548 10444647 100 - 3.379 3.339 -0.132
ENSG00000115758 E016 2179.7701913 0.0007587013 7.106634e-11 1.285648e-09 2 10444931 10445049 119 - 3.387 3.297 -0.302
ENSG00000115758 E017 1329.4645035 0.0026214299 5.073357e-11 9.416404e-10 2 10445155 10445244 90 - 3.212 3.039 -0.575
ENSG00000115758 E018 552.9291639 0.0034502083 3.504964e-16 1.406790e-14 2 10445245 10445264 20 - 2.874 2.608 -0.885
ENSG00000115758 E019 1.2189160 0.0106428306 3.571416e-01 5.015559e-01 2 10446210 10446250 41 - 0.434 0.285 -0.889
ENSG00000115758 E020 2.7439583 0.0063308237 2.727421e-02 6.654668e-02 2 10447474 10447548 75 - 0.737 0.405 -1.531
ENSG00000115758 E021 2.5902528 0.0761574436 8.635191e-02 1.695649e-01 2 10447549 10447627 79 - 0.709 0.403 -1.430
ENSG00000115758 E022 1.9959592 0.0203987958 1.063831e-01 2.001982e-01 2 10447628 10447788 161 - 0.611 0.349 -1.324
ENSG00000115758 E023 655.9705395 0.0223109092 4.049363e-07 3.647661e-06 2 10448121 10448387 267 - 2.991 2.607 -1.279
ENSG00000115758 E024 20.3302122 0.0126717994 1.541050e-01 2.672433e-01 2 10448388 10448484 97 - 1.392 1.275 -0.407
ENSG00000115758 E025 0.6652806 0.0191843105 3.916248e-01 5.355441e-01 2 10448761 10448964 204 - 0.128 0.285 1.432