ENSG00000115652

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000283148 ENSG00000115652 HEK293_OSMI2_2hA HEK293_TMG_2hB UXS1 protein_coding protein_coding 22.57917 16.39321 28.89599 1.189176 1.249921 0.8173901 8.726087 8.051747 9.224659 0.8328322 0.4018423 0.1959661 0.4040250 0.4890667 0.3192333 -0.1698333 3.873148e-08 3.135011e-08 FALSE TRUE
ENST00000409501 ENSG00000115652 HEK293_OSMI2_2hA HEK293_TMG_2hB UXS1 protein_coding protein_coding 22.57917 16.39321 28.89599 1.189176 1.249921 0.8173901 11.042128 6.849719 16.470482 0.4385585 0.7386381 1.2645370 0.4602833 0.4184000 0.5699333 0.1515333 3.135011e-08 3.135011e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115652 E001 0.4751703 0.0206141306 3.608121e-01 5.051754e-01 2 106093308 106093310 3 - 0.102 0.255 1.587
ENSG00000115652 E002 73.8611964 0.0032708161 2.718305e-06 2.054557e-05 2 106093311 106093507 197 - 1.760 1.991 0.779
ENSG00000115652 E003 113.0721197 0.0048098674 1.986636e-07 1.904475e-06 2 106093508 106093603 96 - 1.935 2.174 0.804
ENSG00000115652 E004 180.3928048 0.0018927488 1.263607e-10 2.193590e-09 2 106093604 106093781 178 - 2.153 2.363 0.700
ENSG00000115652 E005 332.7010318 0.0003171370 1.292135e-08 1.560372e-07 2 106093782 106094157 376 - 2.470 2.585 0.382
ENSG00000115652 E006 152.0837171 0.0002684415 1.724697e-02 4.549409e-02 2 106096718 106096821 104 - 2.151 2.223 0.239
ENSG00000115652 E007 9.2592705 0.0112821029 4.403131e-02 9.844454e-02 2 106096822 106097710 889 - 0.883 1.114 0.856
ENSG00000115652 E008 113.8135185 0.0002793337 8.250128e-02 1.634555e-01 2 106098716 106098773 58 - 2.032 2.093 0.204
ENSG00000115652 E009 7.2446554 0.0023448893 7.807585e-01 8.591413e-01 2 106100773 106101046 274 - 0.898 0.934 0.136
ENSG00000115652 E010 1.8435108 0.0079284524 3.407812e-01 4.847245e-01 2 106101047 106101057 11 - 0.367 0.531 0.852
ENSG00000115652 E011 112.9853342 0.0002907493 1.119935e-01 2.084763e-01 2 106101058 106101118 61 - 2.031 2.087 0.189
ENSG00000115652 E012 1.3704314 0.0094199852 6.746285e-01 7.801014e-01 2 106101119 106102952 1834 - 0.414 0.342 -0.413
ENSG00000115652 E013 109.2489815 0.0023569943 9.694007e-01 9.848720e-01 2 106104794 106104837 44 - 2.042 2.042 0.000
ENSG00000115652 E014 0.5138669 0.0209336366 8.294947e-01 8.929368e-01 2 106112643 106112645 3 - 0.185 0.146 -0.409
ENSG00000115652 E015 162.1300436 0.0035537945 2.131087e-01 3.422149e-01 2 106112646 106112765 120 - 2.233 2.187 -0.155
ENSG00000115652 E016 76.1627907 0.0004753183 2.363012e-01 3.698829e-01 2 106122970 106122970 1 - 1.909 1.864 -0.151
ENSG00000115652 E017 146.5469943 0.0002831154 1.702052e-01 2.884517e-01 2 106122971 106123051 81 - 2.188 2.151 -0.122
ENSG00000115652 E018 118.4064357 0.0003088917 1.756438e-02 4.618603e-02 2 106123052 106123091 40 - 2.110 2.036 -0.248
ENSG00000115652 E019 124.0671912 0.0002893428 4.956737e-02 1.083940e-01 2 106125620 106125679 60 - 2.124 2.065 -0.197
ENSG00000115652 E020 143.2501427 0.0037295522 1.059839e-02 3.020526e-02 2 106129674 106129778 105 - 2.202 2.101 -0.337
ENSG00000115652 E021 0.0000000       2 106138175 106138489 315 -      
ENSG00000115652 E022 0.0000000       2 106138490 106138881 392 -      
ENSG00000115652 E023 124.9896819 0.0040861574 3.519236e-03 1.178243e-02 2 106145190 106145268 79 - 2.151 2.025 -0.422
ENSG00000115652 E024 126.6077643 0.0012835971 2.273538e-04 1.080651e-03 2 106145269 106145370 102 - 2.158 2.029 -0.430
ENSG00000115652 E025 1.6972939 0.0084943715 5.309137e-01 6.634347e-01 2 106145371 106145475 105 - 0.367 0.477 0.590
ENSG00000115652 E026 95.9538862 0.0015247446 2.054340e-03 7.394382e-03 2 106158058 106158118 61 - 2.035 1.913 -0.410
ENSG00000115652 E027 1.0404339 0.0116153762 1.392155e-01 2.469857e-01 2 106159145 106159382 238 - 0.414 0.146 -1.998
ENSG00000115652 E028 0.6256415 0.0175709750 5.360473e-01 6.678133e-01 2 106160003 106160397 395 - 0.254 0.146 -0.996
ENSG00000115652 E029 0.6172225 0.4532441069 7.648902e-01 8.478357e-01 2 106160437 106160625 189 - 0.253 0.146 -0.981
ENSG00000115652 E030 84.6597529 0.0003413414 4.013163e-02 9.127799e-02 2 106163667 106163710 44 - 1.964 1.888 -0.256
ENSG00000115652 E031 84.1152893 0.0013697927 1.956916e-04 9.454551e-04 2 106164736 106164784 49 - 1.993 1.837 -0.524
ENSG00000115652 E032 14.4464657 0.0270821402 1.661731e-01 2.832273e-01 2 106164785 106164799 15 - 1.248 1.076 -0.615
ENSG00000115652 E033 61.0221956 0.0012190729 4.704350e-05 2.668019e-04 2 106166056 106166083 28 - 1.868 1.671 -0.664
ENSG00000115652 E034 0.1515154 0.0432857670 7.175534e-01   2 106166201 106166479 279 - 0.102 0.000 -8.895
ENSG00000115652 E035 66.9628307 0.0004022079 1.437581e-05 9.208012e-05 2 106194148 106194238 91 - 1.906 1.717 -0.641
ENSG00000115652 E036 38.3768964 0.0005642959 4.160922e-03 1.359422e-02 2 106194239 106194321 83 - 1.659 1.496 -0.556