ENSG00000115568

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000411696 ENSG00000115568 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF142 protein_coding protein_coding 12.05741 14.02364 10.71946 1.4048 0.0900116 -0.3873123 5.3496125 7.5193752 5.1365140 0.3193330 0.1541484 -0.5489346 0.44246667 0.54303333 0.47910000 -0.06393333 4.931568e-01 1.418956e-18 FALSE TRUE
ENST00000433921 ENSG00000115568 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF142 protein_coding nonsense_mediated_decay 12.05741 14.02364 10.71946 1.4048 0.0900116 -0.3873123 0.3073637 1.3003110 0.0000000 0.1832205 0.0000000 -7.0337655 0.02439583 0.09226667 0.00000000 -0.09226667 1.418956e-18 1.418956e-18 FALSE TRUE
ENST00000440934 ENSG00000115568 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF142 protein_coding protein_coding 12.05741 14.02364 10.71946 1.4048 0.0900116 -0.3873123 0.8701963 0.4429067 0.9035405 0.1569875 0.1036044 1.0122547 0.07717917 0.02993333 0.08443333 0.05450000 1.873276e-02 1.418956e-18 FALSE TRUE
ENST00000449707 ENSG00000115568 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF142 protein_coding protein_coding 12.05741 14.02364 10.71946 1.4048 0.0900116 -0.3873123 3.3908750 3.2901156 2.8595368 0.5355771 0.1330937 -0.2016987 0.27825000 0.23296667 0.26700000 0.03403333 6.589759e-01 1.418956e-18 FALSE TRUE
MSTRG.19965.2 ENSG00000115568 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF142 protein_coding   12.05741 14.02364 10.71946 1.4048 0.0900116 -0.3873123 0.6351871 0.0000000 1.2487170 0.0000000 0.1864601 6.9758101 0.05790417 0.00000000 0.11640000 0.11640000 8.105613e-16 1.418956e-18 TRUE TRUE
MSTRG.19965.5 ENSG00000115568 HEK293_OSMI2_2hA HEK293_TMG_2hB ZNF142 protein_coding   12.05741 14.02364 10.71946 1.4048 0.0900116 -0.3873123 0.5483775 1.4009113 0.1777515 0.5114606 0.1777515 -2.9097313 0.04195833 0.09660000 0.01670000 -0.07990000 1.234728e-01 1.418956e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115568 E001 553.74537 0.0061516172 1.222536e-06 9.964110e-06 2 218633329 218635886 2558 - 2.583 2.801 0.727
ENSG00000115568 E002 17.64761 0.0026661411 8.828084e-02 1.724973e-01 2 218635887 218635887 1 - 1.317 1.207 -0.387
ENSG00000115568 E003 23.11716 0.0008174931 3.219179e-02 7.622249e-02 2 218635888 218635914 27 - 1.434 1.313 -0.421
ENSG00000115568 E004 101.87448 0.0003153450 5.406127e-03 1.703126e-02 2 218635915 218636487 573 - 2.033 1.968 -0.219
ENSG00000115568 E005 281.32170 0.0001569156 4.259157e-17 1.913863e-15 2 218636488 218637915 1428 - 2.517 2.374 -0.475
ENSG00000115568 E006 76.47390 0.0012004639 9.308125e-01 9.604660e-01 2 218637916 218638144 229 - 1.855 1.885 0.102
ENSG00000115568 E007 403.24467 0.0056166411 6.750216e-08 7.087559e-07 2 218638145 218638808 664 - 2.425 2.670 0.816
ENSG00000115568 E008 166.43808 0.0002557128 2.685717e-05 1.616113e-04 2 218640664 218640769 106 - 2.104 2.260 0.523
ENSG00000115568 E009 808.08161 0.0003900279 2.620693e-12 6.011411e-11 2 218642028 218643919 1892 - 2.803 2.937 0.448
ENSG00000115568 E010 363.30823 0.0001932812 6.004754e-02 1.266824e-01 2 218643920 218644804 885 - 2.544 2.543 -0.005
ENSG00000115568 E011 126.39470 0.0012588773 2.361450e-03 8.342558e-03 2 218644805 218645064 260 - 2.130 2.058 -0.242
ENSG00000115568 E012 107.23526 0.0003538699 7.287747e-05 3.940188e-04 2 218646171 218646348 178 - 2.078 1.975 -0.348
ENSG00000115568 E013 229.07168 0.0015819529 1.334728e-06 1.078997e-05 2 218648635 218649459 825 - 2.409 2.303 -0.352
ENSG00000115568 E014 85.46032 0.0027249716 3.049583e-03 1.041169e-02 2 218650359 218650526 168 - 1.978 1.880 -0.330
ENSG00000115568 E015 48.67384 0.0197041081 1.339638e-01 2.396601e-01 2 218651701 218651779 79 - 1.731 1.645 -0.293
ENSG00000115568 E016 36.37380 0.0172179222 1.136990e-01 2.109173e-01 2 218651780 218651822 43 - 1.612 1.518 -0.321
ENSG00000115568 E017 89.85134 0.0052901411 2.182067e-02 5.530249e-02 2 218651823 218652300 478 - 1.989 1.910 -0.265
ENSG00000115568 E018 98.73695 0.0079069100 6.221933e-03 1.919781e-02 2 218656150 218656349 200 - 2.048 1.936 -0.377
ENSG00000115568 E019 77.21224 0.0068695262 2.929956e-03 1.005783e-02 2 218656350 218656463 114 - 1.953 1.822 -0.439
ENSG00000115568 E020 60.03638 0.0004466913 5.604406e-06 3.944341e-05 2 218658701 218658801 101 - 1.871 1.698 -0.584
ENSG00000115568 E021 46.05026 0.0004987212 6.488016e-05 3.552976e-04 2 218658802 218658876 75 - 1.757 1.584 -0.586
ENSG00000115568 E022 49.80575 0.0014598036 4.010697e-06 2.916642e-05 2 218658980 218659035 56 - 1.806 1.600 -0.697
ENSG00000115568 E023 39.95341 0.0011178424 4.945654e-06 3.523123e-05 2 218659036 218659130 95 - 1.724 1.501 -0.759
ENSG00000115568 E024 17.93515 0.0170828295 3.018463e-01 4.436711e-01 2 218659131 218659368 238 - 1.300 1.232 -0.239
ENSG00000115568 E025 43.13375 0.0112997601 7.559618e-04 3.100758e-03 2 218659369 218659655 287 - 1.745 1.538 -0.704