ENSG00000115548

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312912 ENSG00000115548 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM3A protein_coding protein_coding 13.12283 4.046707 20.06286 0.2316783 0.5253385 2.306865 9.9096817 3.31830246 16.0268860 0.05806887 0.7535134 2.2685356 0.72099167 0.823700000 0.79960000 -0.02410000 0.9047830686 0.0005675664 FALSE  
ENST00000462197 ENSG00000115548 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM3A protein_coding processed_transcript 13.12283 4.046707 20.06286 0.2316783 0.5253385 2.306865 0.8452550 0.00000000 0.0000000 0.00000000 0.0000000 0.0000000 0.06854167 0.000000000 0.00000000 0.00000000   0.0005675664 FALSE  
ENST00000466058 ENSG00000115548 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM3A protein_coding processed_transcript 13.12283 4.046707 20.06286 0.2316783 0.5253385 2.306865 0.3247544 0.41806660 0.3258572 0.09032051 0.1083496 -0.3499874 0.04168333 0.101533333 0.01640000 -0.08513333 0.0005675664 0.0005675664    
MSTRG.18794.3 ENSG00000115548 HEK293_OSMI2_2hA HEK293_TMG_2hB KDM3A protein_coding   13.12283 4.046707 20.06286 0.2316783 0.5253385 2.306865 0.4414677 0.04288157 1.4378452 0.04288157 0.6980694 4.7749985 0.03197083 0.009566667 0.07063333 0.06106667 0.1456673031 0.0005675664 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115548 E001 0.0000000       2 86440647 86440800 154 +      
ENSG00000115548 E002 0.4783925 0.0210308397 4.710348e-01 6.101992e-01 2 86440801 86440962 162 + 0.110 0.240 1.356
ENSG00000115548 E003 0.0000000       2 86441272 86441338 67 +      
ENSG00000115548 E004 0.8731125 0.3570660728 4.828799e-01 6.209945e-01 2 86441339 86441370 32 + 0.269 0.000 -11.691
ENSG00000115548 E005 2.6600218 0.4925241529 4.686895e-01 6.080893e-01 2 86441371 86441378 8 + 0.534 0.241 -1.709
ENSG00000115548 E006 2.6600218 0.4925241529 4.686895e-01 6.080893e-01 2 86441379 86441379 1 + 0.534 0.241 -1.709
ENSG00000115548 E007 21.8588992 0.0262882615 5.921548e-01 7.147623e-01 2 86441380 86441444 65 + 1.267 1.219 -0.171
ENSG00000115548 E008 0.7300161 0.0581455548 4.003023e-01 5.439925e-01 2 86441461 86441488 28 + 0.235 0.000 -11.437
ENSG00000115548 E009 0.1472490 0.0437792797 1.000000e+00   2 86441995 86442017 23 + 0.058 0.000 -9.116
ENSG00000115548 E010 67.8713540 0.0004528355 1.850645e-01 3.075783e-01 2 86442018 86442233 216 + 1.744 1.695 -0.166
ENSG00000115548 E011 0.1451727 0.0431827210 1.000000e+00   2 86442324 86442594 271 + 0.058 0.000 -9.116
ENSG00000115548 E012 4.9934589 0.0562556752 2.498456e-07 2.350174e-06 2 86443178 86443534 357 + 0.361 1.227 3.611
ENSG00000115548 E013 28.9799947 0.0028546301 2.141344e-02 5.445909e-02 2 86449807 86449813 7 + 1.406 1.216 -0.662
ENSG00000115548 E014 78.7028285 0.0003603764 1.416866e-05 9.087314e-05 2 86449814 86449962 149 + 1.832 1.610 -0.751
ENSG00000115548 E015 65.7080290 0.0003668034 1.654027e-05 1.045407e-04 2 86451103 86451213 111 + 1.759 1.514 -0.833
ENSG00000115548 E016 49.1621193 0.0004879670 1.738780e-04 8.521929e-04 2 86455085 86455187 103 + 1.636 1.390 -0.844
ENSG00000115548 E017 0.5922303 0.0179940599 6.820932e-01 7.856084e-01 2 86456433 86456441 9 + 0.156 0.239 0.769
ENSG00000115548 E018 65.4119206 0.0003598777 3.132077e-05 1.855011e-04 2 86456442 86456566 125 + 1.758 1.524 -0.797
ENSG00000115548 E019 0.1472490 0.0437792797 1.000000e+00   2 86456567 86456655 89 + 0.058 0.000 -9.116
ENSG00000115548 E020 59.4670605 0.0004343678 4.722517e-04 2.053966e-03 2 86456805 86456877 73 + 1.713 1.514 -0.678
ENSG00000115548 E021 60.3790071 0.0004576296 9.797484e-04 3.890714e-03 2 86456983 86457071 89 + 1.717 1.533 -0.625
ENSG00000115548 E022 2.6552038 0.0058663484 1.811810e-02 4.738360e-02 2 86460779 86460831 53 + 0.555 0.000 -13.286
ENSG00000115548 E023 75.4301368 0.0170236508 5.201976e-02 1.127558e-01 2 86464053 86464216 164 + 1.805 1.672 -0.452
ENSG00000115548 E024 92.4501618 0.0004340620 1.326094e-04 6.703074e-04 2 86466372 86466631 260 + 1.897 1.726 -0.575
ENSG00000115548 E025 71.8892193 0.0011837243 1.054777e-05 6.974912e-05 2 86466632 86466777 146 + 1.798 1.551 -0.839
ENSG00000115548 E026 65.9556563 0.0003680877 2.383534e-03 8.408816e-03 2 86466778 86466883 106 + 1.750 1.594 -0.529
ENSG00000115548 E027 0.0000000       2 86467339 86467368 30 +      
ENSG00000115548 E028 104.3456751 0.0029844400 2.556949e-03 8.933267e-03 2 86470204 86470408 205 + 1.942 1.804 -0.467
ENSG00000115548 E029 100.7212384 0.0003057071 1.777382e-02 4.665193e-02 2 86474776 86474947 172 + 1.918 1.832 -0.289
ENSG00000115548 E030 47.9544635 0.0005078845 4.733666e-01 6.123002e-01 2 86474948 86474990 43 + 1.591 1.569 -0.074
ENSG00000115548 E031 27.2917786 0.0009404714 1.834516e-01 3.055435e-01 2 86477877 86477881 5 + 1.365 1.271 -0.326
ENSG00000115548 E032 81.0563389 0.0003425311 1.116018e-02 3.155005e-02 2 86477882 86478029 148 + 1.829 1.720 -0.367
ENSG00000115548 E033 0.4418608 0.0255837465 7.813174e-01 8.595267e-01 2 86478030 86478169 140 + 0.156 0.000 -10.701
ENSG00000115548 E034 80.6517958 0.0003410114 2.189340e-01 3.491221e-01 2 86478170 86478265 96 + 1.815 1.777 -0.127
ENSG00000115548 E035 85.2581533 0.0003511433 7.120306e-01 8.088748e-01 2 86478608 86478735 128 + 1.830 1.837 0.024
ENSG00000115548 E036 11.4135585 0.0014893301 1.158472e-01 2.140159e-01 2 86478736 86480166 1431 + 1.027 0.838 -0.711
ENSG00000115548 E037 82.1540209 0.0003435757 4.470838e-01 5.885123e-01 2 86480167 86480362 196 + 1.802 1.864 0.209
ENSG00000115548 E038 91.4375814 0.0003537376 3.651974e-01 5.095378e-01 2 86481930 86482102 173 + 1.847 1.914 0.224
ENSG00000115548 E039 134.2359740 0.0002459313 6.976670e-01 7.977522e-01 2 86482458 86482694 237 + 2.018 2.058 0.134
ENSG00000115548 E040 8.9050667 0.0098880935 1.449954e-01 2.548288e-01 2 86482695 86483986 1292 + 0.936 0.733 -0.790
ENSG00000115548 E041 103.5912224 0.0003017160 3.003615e-01 4.420339e-01 2 86483987 86484158 172 + 1.902 1.972 0.234
ENSG00000115548 E042 0.0000000       2 86484681 86484718 38 +      
ENSG00000115548 E043 72.1399632 0.0012504589 5.632191e-01 6.907278e-01 2 86484942 86485029 88 + 1.762 1.756 -0.022
ENSG00000115548 E044 99.4340729 0.0003079167 5.291259e-01 6.619516e-01 2 86485729 86485859 131 + 1.887 1.940 0.178
ENSG00000115548 E045 3.0991515 0.0050021740 7.970821e-01 8.705122e-01 2 86486928 86487693 766 + 0.537 0.506 -0.147
ENSG00000115548 E046 7.2304679 0.0031786598 7.287740e-01 8.211598e-01 2 86487694 86489176 1483 + 0.811 0.882 0.277
ENSG00000115548 E047 2.6207590 0.0057882681 5.398695e-01 6.710890e-01 2 86489177 86489317 141 + 0.499 0.393 -0.551
ENSG00000115548 E048 108.8518931 0.0005205610 1.252157e-01 2.274398e-01 2 86489318 86489437 120 + 1.918 2.008 0.301
ENSG00000115548 E049 5.1888750 0.0208352731 3.816434e-01 5.259497e-01 2 86489438 86489519 82 + 0.676 0.837 0.652
ENSG00000115548 E050 46.5339161 0.0012437967 1.410577e-01 2.494862e-01 2 86489520 86489522 3 + 1.551 1.669 0.402
ENSG00000115548 E051 97.5582230 0.0009127033 8.867403e-03 2.595046e-02 2 86489523 86489659 137 + 1.860 2.001 0.474
ENSG00000115548 E052 5.2433907 0.0030218716 3.518153e-01 4.960219e-01 2 86489660 86490880 1221 + 0.676 0.838 0.654
ENSG00000115548 E053 119.6191136 0.0002437082 4.832009e-11 8.999308e-10 2 86490881 86491057 177 + 1.913 2.179 0.893
ENSG00000115548 E054 105.5127109 0.0006625390 8.112840e-10 1.223299e-08 2 86491141 86491275 135 + 1.861 2.132 0.909
ENSG00000115548 E055 1.8747465 0.0077805204 4.932327e-02 1.079624e-01 2 86491276 86492038 763 + 0.303 0.670 1.869
ENSG00000115548 E056 223.3700129 0.0149879079 1.023373e-06 8.469110e-06 2 86492039 86492716 678 + 2.163 2.494 1.105