ENSG00000115526

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264249 ENSG00000115526 HEK293_OSMI2_2hA HEK293_TMG_2hB CHST10 protein_coding protein_coding 23.06523 25.69735 21.66906 0.7238124 0.5798173 -0.2458785 19.909868 23.5339394 18.184899 0.33159114 0.2188796 -0.3718217 0.85890833 0.916500000 0.8408 -0.07570000 1.475362e-01 3.992039e-07 FALSE TRUE
MSTRG.18927.2 ENSG00000115526 HEK293_OSMI2_2hA HEK293_TMG_2hB CHST10 protein_coding   23.06523 25.69735 21.66906 0.7238124 0.5798173 -0.2458785 1.055651 0.1595342 1.661034 0.04549744 0.3611898 3.3010926 0.05069167 0.006233333 0.0766 0.07036667 3.992039e-07 3.992039e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115526 E001 562.1328121 0.0070510342 1.058547e-07 1.070510e-06 2 100391860 100392606 747 - 2.590 2.823 0.776
ENSG00000115526 E002 563.1600010 0.0030592245 1.466046e-02 3.972795e-02 2 100392607 100393244 638 - 2.684 2.780 0.321
ENSG00000115526 E003 168.2377848 0.0002422596 8.936430e-01 9.359633e-01 2 100393245 100393340 96 - 2.201 2.237 0.120
ENSG00000115526 E004 98.6126283 0.0003012379 2.205265e-01 3.510357e-01 2 100393341 100393348 8 - 2.000 1.989 -0.039
ENSG00000115526 E005 113.7068050 0.0002828767 3.907651e-01 5.347165e-01 2 100393349 100393375 27 - 2.053 2.057 0.012
ENSG00000115526 E006 337.8559235 0.0001468127 1.561893e-02 4.188609e-02 2 100393376 100393782 407 - 2.531 2.517 -0.045
ENSG00000115526 E007 129.4392751 0.0020996227 6.441085e-02 1.340566e-01 2 100395509 100395614 106 - 2.130 2.092 -0.128
ENSG00000115526 E008 56.8361132 0.0010845938 4.681249e-01 6.075491e-01 2 100397908 100397910 3 - 1.756 1.752 -0.013
ENSG00000115526 E009 78.4446368 0.0008624208 7.444015e-01 8.327702e-01 2 100397911 100397935 25 - 1.881 1.899 0.060
ENSG00000115526 E010 176.0911139 0.0029489571 1.468541e-01 2.573998e-01 2 100397936 100398051 116 - 2.253 2.232 -0.069
ENSG00000115526 E011 118.0919368 0.0002796895 2.645392e-02 6.485682e-02 2 100398052 100398079 28 - 2.093 2.052 -0.135
ENSG00000115526 E012 152.1544982 0.0002749972 2.108337e-02 5.377412e-02 2 100398080 100398142 63 - 2.198 2.164 -0.115
ENSG00000115526 E013 161.9391576 0.0035934923 4.993455e-02 1.090547e-01 2 100402564 100402655 92 - 2.230 2.185 -0.150
ENSG00000115526 E014 138.3686895 0.0067353514 5.700645e-03 1.781894e-02 2 100406576 100406707 132 - 2.194 2.091 -0.344
ENSG00000115526 E015 3.1396443 0.0050257354 5.481744e-01 6.780491e-01 2 100407447 100407602 156 - 0.662 0.596 -0.285
ENSG00000115526 E016 2.0000341 0.2477171731 4.221847e-01 5.653489e-01 2 100407673 100407706 34 - 0.318 0.577 1.362
ENSG00000115526 E017 1.1405657 0.1323190523 4.943641e-01 6.313079e-01 2 100407793 100407892 100 - 0.387 0.276 -0.693
ENSG00000115526 E018 0.1515154 0.0433416438 3.821736e-01   2 100408174 100408542 369 - 0.133 0.000 -9.358
ENSG00000115526 E019 6.7189422 0.0025245583 8.196709e-01 8.861432e-01 2 100408543 100408660 118 - 0.851 0.907 0.214
ENSG00000115526 E020 53.2979421 0.0219846494 8.019635e-02 1.598535e-01 2 100415041 100415052 12 - 1.790 1.674 -0.394
ENSG00000115526 E021 81.1109482 0.0135487759 8.307572e-04 3.368891e-03 2 100415053 100415111 59 - 2.010 1.816 -0.650
ENSG00000115526 E022 0.0000000       2 100415774 100415845 72 -      
ENSG00000115526 E023 2.1777773 0.0070257362 1.192874e-01 2.189240e-01 2 100416223 100416525 303 - 0.626 0.393 -1.132
ENSG00000115526 E024 1.9177070 0.0084133793 6.426383e-01 7.553928e-01 2 100416723 100416847 125 - 0.387 0.487 0.526
ENSG00000115526 E025 3.4729356 0.0094738780 4.593037e-01 5.995033e-01 2 100416848 100416988 141 - 0.546 0.685 0.612
ENSG00000115526 E026 2.8064099 0.0060540260 8.640647e-01 9.163397e-01 2 100416989 100417070 82 - 0.546 0.597 0.231
ENSG00000115526 E027 1.7368338 0.1335566946 9.098177e-01 9.466863e-01 2 100417071 100417130 60 - 0.446 0.438 -0.043
ENSG00000115526 E028 2.7279448 0.2034202992 2.326360e-01 3.655775e-01 2 100417131 100417255 125 - 0.386 0.656 1.298
ENSG00000115526 E029 4.6767882 0.0109566086 8.532583e-01 9.091520e-01 2 100417258 100417373 116 - 0.725 0.778 0.216
ENSG00000115526 E030 76.8355762 0.0097678339 1.212584e-05 7.902316e-05 2 100417374 100417668 295 - 2.006 1.767 -0.804