ENSG00000115524

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-4 / 4
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000335508	ENSG00000115524	HEK293_OSMI2_2hA	HEK293_TMG_2hB	SF3B1	protein_coding	protein_coding	106.4757	41.30007	158.4261	4.591954	3.739834	1.939336	47.859296	12.5672231	78.409445	0.35649610	1.339937	2.640398	0.40215000	0.311233333	0.49510000	0.18386667	0.0008358293	4.858999e-07	FALSE	TRUE
ENST00000409915	ENSG00000115524	HEK293_OSMI2_2hA	HEK293_TMG_2hB	SF3B1	protein_coding	nonsense_mediated_decay	106.4757	41.30007	158.4261	4.591954	3.739834	1.939336	7.965551	0.1437065	12.851465	0.07334249	1.602834	6.386733	0.05080417	0.003866667	0.08073333	0.07686667	0.0002439106	4.858999e-07	TRUE	TRUE
ENST00000424674	ENSG00000115524	HEK293_OSMI2_2hA	HEK293_TMG_2hB	SF3B1	protein_coding	protein_coding	106.4757	41.30007	158.4261	4.591954	3.739834	1.939336	34.103356	16.6912441	48.356902	1.98780961	1.984371	1.534065	0.34567917	0.405366667	0.30543333	-0.09993333	0.1149354628	4.858999e-07	FALSE	FALSE
ENST00000479532	ENSG00000115524	HEK293_OSMI2_2hA	HEK293_TMG_2hB	SF3B1	protein_coding	retained_intron	106.4757	41.30007	158.4261	4.591954	3.739834	1.939336	8.900406	11.1890359	4.389429	2.96675902	2.206110	-1.347986	0.14491667	0.263133333	0.02800000	-0.23513333	0.2055891688	4.858999e-07	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 47
Columns:
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000115524	E001	2.0745104	0.0068314233	5.546755e-01	6.836210e-01	2	197388515	197389783	1269	-	0.379	0.516	0.706
ENSG00000115524	E002	0.3697384	0.0246905512	1.282134e-02	3.549456e-02	2	197389784	197389791	8	-	0.000	0.401	13.220
ENSG00000115524	E003	747.6182454	0.0166902839	3.186498e-08	3.568858e-07	2	197389792	197392254	2463	-	2.658	3.055	1.319
ENSG00000115524	E004	730.8398335	0.0128430086	6.619469e-09	8.440157e-08	2	197392255	197392461	207	-	2.658	3.028	1.232
ENSG00000115524	E005	561.4220893	0.0049096695	4.821374e-10	7.566226e-09	2	197392972	197393051	80	-	2.574	2.849	0.915
ENSG00000115524	E006	800.0488333	0.0033992308	1.388874e-11	2.826794e-10	2	197393052	197393186	135	-	2.735	2.984	0.828
ENSG00000115524	E007	390.1935117	0.0005438356	4.626744e-20	2.957229e-18	2	197393187	197393188	2	-	2.424	2.675	0.837
ENSG00000115524	E008	3.6095806	0.0058314968	1.080277e-01	2.026149e-01	2	197393189	197393351	163	-	0.510	0.800	1.250
ENSG00000115524	E009	1062.8697168	0.0005112487	4.320849e-23	3.870317e-21	2	197396056	197396328	273	-	2.872	3.069	0.657
ENSG00000115524	E010	0.2987644	0.0273636323	1.000000e+00		2	197397954	197397984	31	-	0.107	0.000	-8.610
ENSG00000115524	E011	706.0243995	0.0028313678	2.300079e-03	8.150824e-03	2	197397985	197398116	132	-	2.711	2.838	0.424
ENSG00000115524	E012	592.2293682	0.0001447711	1.021575e-06	8.455341e-06	2	197398461	197398581	121	-	2.636	2.762	0.420
ENSG00000115524	E013	3.9620336	0.0040050659	4.677874e-01	6.072795e-01	2	197398582	197398772	191	-	0.624	0.515	-0.496
ENSG00000115524	E014	5.5900406	0.0109760527	1.432839e-01	2.524924e-01	2	197398969	197399028	60	-	0.759	0.516	-1.058
ENSG00000115524	E015	621.4434203	0.0001595185	8.403834e-03	2.479839e-02	2	197400055	197400166	112	-	2.666	2.751	0.281
ENSG00000115524	E016	710.9098466	0.0004533375	2.845994e-01	4.248438e-01	2	197400252	197400434	183	-	2.730	2.786	0.186
ENSG00000115524	E017	748.0385068	0.0006254148	9.167003e-01	9.513606e-01	2	197400715	197400936	222	-	2.756	2.788	0.107
ENSG00000115524	E018	563.1636136	0.0025392508	3.599997e-01	5.043175e-01	2	197401400	197401525	126	-	2.638	2.641	0.012
ENSG00000115524	E019	547.7572737	0.0077287630	4.180223e-01	5.613345e-01	2	197401742	197401888	147	-	2.628	2.621	-0.022
ENSG00000115524	E020	331.7268200	0.0050017417	4.446795e-02	9.923387e-02	2	197401985	197402021	37	-	2.418	2.363	-0.185
ENSG00000115524	E021	442.8073294	0.0047411433	1.661386e-01	2.831838e-01	2	197402022	197402130	109	-	2.538	2.515	-0.079
ENSG00000115524	E022	5.6970953	0.0046668134	6.064018e-01	7.265569e-01	2	197402421	197402555	135	-	0.738	0.681	-0.235
ENSG00000115524	E023	695.8053438	0.0001112563	3.920698e-07	3.540177e-06	2	197402556	197402826	271	-	2.741	2.682	-0.194
ENSG00000115524	E024	412.3432450	0.0008119840	1.389389e-04	6.989447e-04	2	197402949	197403035	87	-	2.516	2.446	-0.232
ENSG00000115524	E025	519.4779983	0.0032382817	3.593027e-04	1.616031e-03	2	197403585	197403764	180	-	2.619	2.526	-0.311
ENSG00000115524	E026	396.4075810	0.0185866515	8.060259e-02	1.604933e-01	2	197405076	197405177	102	-	2.502	2.413	-0.297
ENSG00000115524	E027	600.4399278	0.0062750074	2.981368e-04	1.371933e-03	2	197405275	197405472	198	-	2.687	2.561	-0.418
ENSG00000115524	E028	0.9027498	0.4052290482	5.239627e-01	6.576028e-01	2	197407936	197407997	62	-	0.266	0.000	-10.206
ENSG00000115524	E029	521.8939180	0.0048435929	1.160253e-07	1.165155e-06	2	197407998	197408119	122	-	2.635	2.450	-0.616
ENSG00000115524	E030	671.6518097	0.0063211911	1.045306e-07	1.057853e-06	2	197408369	197408581	213	-	2.746	2.545	-0.667
ENSG00000115524	E031	0.7415557	0.1263502670	8.541067e-01	9.097336e-01	2	197408582	197408694	113	-	0.193	0.244	0.432
ENSG00000115524	E032	645.0909274	0.0076115214	2.999867e-07	2.776232e-06	2	197409770	197410007	238	-	2.729	2.519	-0.699
ENSG00000115524	E033	0.0000000				2	197416594	197416740	147	-
ENSG00000115524	E034	393.2771949	0.0025462838	2.883230e-09	3.926810e-08	2	197416741	197416890	150	-	2.511	2.330	-0.604
ENSG00000115524	E035	240.1679377	0.0054553033	3.666815e-07	3.332536e-06	2	197416891	197416911	21	-	2.302	2.077	-0.751
ENSG00000115524	E036	388.6808799	0.0061551996	7.397321e-07	6.322582e-06	2	197418509	197418588	80	-	2.508	2.306	-0.673
ENSG00000115524	E037	48.2496326	0.0012886278	1.538694e-05	9.794398e-05	2	197418589	197418795	207	-	1.624	1.317	-1.056
ENSG00000115524	E038	23.1251840	0.0024942959	2.110721e-04	1.011202e-03	2	197418796	197418895	100	-	1.327	0.934	-1.416
ENSG00000115524	E039	30.9408403	0.0055216424	8.714128e-05	4.616127e-04	2	197418896	197418951	56	-	1.446	1.065	-1.344
ENSG00000115524	E040	99.4762960	0.0024166097	1.301753e-18	7.068306e-17	2	197418952	197419640	689	-	1.952	1.376	-1.958
ENSG00000115524	E041	76.1347988	0.0007881987	2.741894e-19	1.615185e-17	2	197419641	197420180	540	-	1.842	1.188	-2.249
ENSG00000115524	E042	40.8251031	0.0079722847	3.296316e-07	3.023956e-06	2	197420181	197420427	247	-	1.569	1.066	-1.760
ENSG00000115524	E043	501.4965198	0.0036543143	6.936648e-11	1.257418e-09	2	197420428	197420542	115	-	2.620	2.404	-0.721
ENSG00000115524	E044	472.8822584	0.0005152209	2.030260e-18	1.076783e-16	2	197421029	197421133	105	-	2.592	2.399	-0.644
ENSG00000115524	E045	427.6571966	0.0030055226	4.506599e-11	8.426388e-10	2	197423808	197423893	86	-	2.551	2.337	-0.713
ENSG00000115524	E046	378.0657677	0.0001678745	2.565653e-21	1.906847e-19	2	197423894	197423974	81	-	2.499	2.275	-0.748
ENSG00000115524	E047	270.7457866	0.0001586120	3.272563e-16	1.320505e-14	2	197434972	197435079	108	-	2.355	2.129	-0.757

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000115524

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3