ENSG00000115504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000405289 ENSG00000115504 HEK293_OSMI2_2hA HEK293_TMG_2hB EHBP1 protein_coding protein_coding 11.16104 6.088243 16.15405 0.2841511 0.3670091 1.406323 1.0591314 0.0000000 0.7482698 0.0000000 0.7482698 6.244639 0.06885417 0.00000000 0.0443000 0.04430000 9.812596e-01 1.109925e-60 FALSE TRUE
ENST00000496857 ENSG00000115504 HEK293_OSMI2_2hA HEK293_TMG_2hB EHBP1 protein_coding processed_transcript 11.16104 6.088243 16.15405 0.2841511 0.3670091 1.406323 1.0741256 2.5521900 0.0000000 0.1612760 0.0000000 -8.001234 0.17760833 0.41863333 0.0000000 -0.41863333 1.109925e-60 1.109925e-60 FALSE TRUE
MSTRG.18483.10 ENSG00000115504 HEK293_OSMI2_2hA HEK293_TMG_2hB EHBP1 protein_coding   11.16104 6.088243 16.15405 0.2841511 0.3670091 1.406323 0.7446693 0.2106061 2.1609344 0.1207730 0.4155064 3.298771 0.06851250 0.03296667 0.1334000 0.10043333 1.175031e-01 1.109925e-60 FALSE TRUE
MSTRG.18483.15 ENSG00000115504 HEK293_OSMI2_2hA HEK293_TMG_2hB EHBP1 protein_coding   11.16104 6.088243 16.15405 0.2841511 0.3670091 1.406323 5.3242347 2.6185759 8.0223529 0.2066521 0.2169167 1.611541 0.47427083 0.43340000 0.4969333 0.06353333 5.731288e-01 1.109925e-60 FALSE TRUE
MSTRG.18483.9 ENSG00000115504 HEK293_OSMI2_2hA HEK293_TMG_2hB EHBP1 protein_coding   11.16104 6.088243 16.15405 0.2841511 0.3670091 1.406323 1.4328186 0.1461572 2.5248107 0.1073576 0.3640775 4.020807 0.09273333 0.02583333 0.1572667 0.13143333 2.924752e-02 1.109925e-60 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115504 E001 0.0000000       2 62673851 62673877 27 +      
ENSG00000115504 E002 0.1451727 0.0424626684 1.000000e+00   2 62673878 62674083 206 + 0.072 0.000 -9.913
ENSG00000115504 E003 0.0000000       2 62674084 62674093 10 +      
ENSG00000115504 E004 0.1451727 0.0424626684 1.000000e+00   2 62705652 62705661 10 + 0.072 0.000 -9.901
ENSG00000115504 E005 0.7300161 0.0380747165 2.024816e-01 3.293173e-01 2 62705662 62705704 43 + 0.279 0.000 -12.222
ENSG00000115504 E006 0.8772652 0.0611091642 1.491284e-01 2.604901e-01 2 62705705 62705711 7 + 0.319 0.000 -12.484
ENSG00000115504 E007 0.8772652 0.0611091642 1.491284e-01 2.604901e-01 2 62705712 62705712 1 + 0.319 0.000 -12.484
ENSG00000115504 E008 8.7561766 0.0019223837 2.051524e-01 3.326102e-01 2 62705713 62705736 24 + 0.977 0.836 -0.536
ENSG00000115504 E009 0.2944980 0.3576475460 8.658620e-01   2 62705737 62705817 81 + 0.134 0.000 -10.900
ENSG00000115504 E010 0.7644715 0.0183669202 8.228644e-01 8.883233e-01 2 62705818 62705865 48 + 0.236 0.200 -0.302
ENSG00000115504 E011 4.1108018 0.0686767192 4.054514e-01 5.491442e-01 2 62705866 62705882 17 + 0.628 0.792 0.680
ENSG00000115504 E012 28.8845961 0.0099043720 2.255741e-03 8.017249e-03 2 62705883 62706052 170 + 1.338 1.609 0.933
ENSG00000115504 E013 0.7675920 0.0161650487 4.521292e-01 5.930152e-01 2 62706313 62706754 442 + 0.188 0.337 1.111
ENSG00000115504 E014 100.3007569 0.0002747191 9.106366e-01 9.472003e-01 2 62706897 62707191 295 + 1.946 1.974 0.094
ENSG00000115504 E015 53.9353311 0.0009563351 2.672797e-01 4.055759e-01 2 62707192 62707295 104 + 1.697 1.659 -0.131
ENSG00000115504 E016 40.3114472 0.0010817121 4.899035e-02 1.073639e-01 2 62747395 62747452 58 + 1.589 1.482 -0.365
ENSG00000115504 E017 53.4852830 0.0171698338 9.164790e-02 1.777079e-01 2 62764266 62764361 96 + 1.711 1.593 -0.401
ENSG00000115504 E018 42.8664091 0.0005383128 2.353201e-04 1.113988e-03 2 62771339 62771392 54 + 1.638 1.418 -0.753
ENSG00000115504 E019 0.1482932 0.0414048063 1.507908e-01   2 62771393 62772134 742 + 0.000 0.200 13.016
ENSG00000115504 E020 67.9941156 0.0061350552 1.685360e-05 1.063005e-04 2 62826087 62826268 182 + 1.842 1.582 -0.882
ENSG00000115504 E021 0.0000000       2 62826269 62826581 313 +      
ENSG00000115504 E022 63.2393362 0.0161561868 7.180244e-04 2.963434e-03 2 62831019 62831158 140 + 1.812 1.556 -0.869
ENSG00000115504 E023 0.0000000       2 62858406 62858510 105 +      
ENSG00000115504 E024 51.9435630 0.0009742911 2.896426e-04 1.337752e-03 2 62859169 62859291 123 + 1.717 1.522 -0.666
ENSG00000115504 E025 68.4898791 0.0003793343 7.790305e-05 4.181115e-04 2 62864731 62864971 241 + 1.833 1.653 -0.609
ENSG00000115504 E026 0.0000000       2 62872038 62872096 59 +      
ENSG00000115504 E027 73.1536966 0.0003579688 3.017398e-07 2.791060e-06 2 62874346 62874532 187 + 1.874 1.635 -0.806
ENSG00000115504 E028 0.1482932 0.0414048063 1.507908e-01   2 62881692 62881777 86 + 0.000 0.200 13.016
ENSG00000115504 E029 73.9407397 0.0003896152 4.530098e-10 7.151779e-09 2 62942718 62942896 179 + 1.889 1.585 -1.028
ENSG00000115504 E030 33.4206166 0.0006102287 2.842861e-04 1.315964e-03 2 62943802 62943850 49 + 1.544 1.296 -0.858
ENSG00000115504 E031 32.9131995 0.0006548966 1.737491e-02 4.576659e-02 2 62948260 62948291 32 + 1.516 1.367 -0.515
ENSG00000115504 E032 31.5647327 0.0006461669 9.440516e-02 1.819962e-01 2 62948292 62948316 25 + 1.486 1.388 -0.338
ENSG00000115504 E033 143.6300998 0.0003426573 5.152139e-02 1.118575e-01 2 62948317 62948932 616 + 2.120 2.077 -0.142
ENSG00000115504 E034 72.1630550 0.0005755595 2.355261e-01 3.689928e-01 2 62948933 62949093 161 + 1.789 1.867 0.264
ENSG00000115504 E035 50.8926855 0.0004685160 5.345673e-01 6.666020e-01 2 62949094 62949162 69 + 1.649 1.706 0.193
ENSG00000115504 E036 65.2601921 0.0029484120 8.418405e-01 9.013867e-01 2 62955517 62955614 98 + 1.768 1.780 0.039
ENSG00000115504 E037 48.8767101 0.0015103471 7.343718e-01 8.253465e-01 2 62955615 62955660 46 + 1.649 1.652 0.012
ENSG00000115504 E038 1.2931122 0.0100810662 1.261304e-01 2.287655e-01 2 62955661 62956117 457 + 0.236 0.524 1.696
ENSG00000115504 E039 0.0000000       2 62964962 62965037 76 +      
ENSG00000115504 E040 29.3049043 0.0027398895 4.239704e-01 5.669829e-01 2 62979188 62979190 3 + 1.446 1.408 -0.131
ENSG00000115504 E041 66.5645787 0.0026429800 7.560381e-02 1.524752e-01 2 62979191 62979322 132 + 1.799 1.725 -0.249
ENSG00000115504 E042 38.3017371 0.0005807176 7.172176e-01 8.126770e-01 2 62979323 62979335 13 + 1.544 1.544 0.000
ENSG00000115504 E043 53.6110798 0.0005046741 3.148997e-01 4.576522e-01 2 62987931 62988038 108 + 1.696 1.664 -0.108
ENSG00000115504 E044 80.6994866 0.0009699558 7.119103e-02 1.453160e-01 2 62990716 62990840 125 + 1.877 1.816 -0.204
ENSG00000115504 E045 98.7366162 0.0011388948 8.054520e-01 8.763020e-01 2 62993530 62993668 139 + 1.937 1.972 0.116
ENSG00000115504 E046 86.3932309 0.0003479330 6.956007e-03 2.110903e-02 2 62993871 62993977 107 + 1.848 1.982 0.452
ENSG00000115504 E047 0.6674587 0.0260877280 1.000000e+00 1.000000e+00 2 62993978 62994177 200 + 0.188 0.201 0.114
ENSG00000115504 E048 82.5893152 0.0003486372 2.995571e-03 1.025075e-02 2 62996643 62996766 124 + 1.824 1.971 0.497
ENSG00000115504 E049 78.9985778 0.0003707733 2.090457e-05 1.290927e-04 2 63037535 63037634 100 + 1.784 1.987 0.684
ENSG00000115504 E050 70.2859605 0.0013901467 3.195421e-04 1.459057e-03 2 63038743 63038816 74 + 1.735 1.929 0.655
ENSG00000115504 E051 4.5793422 0.0241430141 3.818104e-01 5.260911e-01 2 63044839 63045065 227 + 0.727 0.596 -0.558
ENSG00000115504 E052 86.1623227 0.0014291393 3.647894e-02 8.449166e-02 2 63045066 63045180 115 + 1.853 1.969 0.390
ENSG00000115504 E053 284.8394162 0.0064516945 3.201485e-12 7.234158e-11 2 63045410 63046487 1078 + 2.300 2.605 1.018