ENSG00000115486

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000233838 ENSG00000115486 HEK293_OSMI2_2hA HEK293_TMG_2hB GGCX protein_coding protein_coding 44.8296 66.20056 32.56631 1.171992 2.228273 -1.023238 2.728158 2.517327 2.732384 0.1779825 0.06251614 0.1178184 0.06731250 0.03813333 0.08453333 0.0464000 1.657198e-05 1.001731e-08 FALSE TRUE
ENST00000430215 ENSG00000115486 HEK293_OSMI2_2hA HEK293_TMG_2hB GGCX protein_coding protein_coding 44.8296 66.20056 32.56631 1.171992 2.228273 -1.023238 7.337093 9.077323 7.721795 1.0575017 0.34275921 -0.2330519 0.17279167 0.13680000 0.23793333 0.1011333 9.026741e-04 1.001731e-08 FALSE TRUE
ENST00000481541 ENSG00000115486 HEK293_OSMI2_2hA HEK293_TMG_2hB GGCX protein_coding protein_coding 44.8296 66.20056 32.56631 1.171992 2.228273 -1.023238 2.848930 5.829603 1.229597 0.6799737 0.29141511 -2.2359989 0.05772083 0.08786667 0.03796667 -0.0499000 3.481040e-02 1.001731e-08   FALSE
ENST00000496962 ENSG00000115486 HEK293_OSMI2_2hA HEK293_TMG_2hB GGCX protein_coding protein_coding 44.8296 66.20056 32.56631 1.171992 2.228273 -1.023238 26.014697 42.014125 15.567321 0.7008220 1.96331262 -1.4317706 0.56507083 0.63483333 0.47416667 -0.1606667 1.774181e-03 1.001731e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115486 E001 190.3302046 0.0012835113 5.673575e-05 3.152583e-04 2 85544720 85547619 2900 - 2.334 2.222 -0.374
ENSG00000115486 E002 42.9663244 0.0005280251 1.409086e-10 2.425469e-09 2 85547620 85548004 385 - 1.811 1.480 -1.125
ENSG00000115486 E003 19.0846453 0.0009965863 1.852439e-05 1.158176e-04 2 85548005 85548091 87 - 1.469 1.147 -1.124
ENSG00000115486 E004 98.6820632 0.0117099897 9.342004e-07 7.800320e-06 2 85548092 85549081 990 - 2.150 1.851 -1.003
ENSG00000115486 E005 11.4906346 0.0183196964 4.546538e-02 1.010486e-01 2 85549082 85549083 2 - 1.205 0.984 -0.800
ENSG00000115486 E006 12.0118884 0.0217905749 6.428297e-02 1.338438e-01 2 85549084 85549088 5 - 1.216 1.007 -0.753
ENSG00000115486 E007 67.0777415 0.0009889193 1.002264e-01 1.908256e-01 2 85549089 85549346 258 - 1.858 1.792 -0.220
ENSG00000115486 E008 126.8486010 0.0036168489 3.510876e-01 4.952900e-01 2 85549347 85549682 336 - 2.107 2.078 -0.098
ENSG00000115486 E009 93.5964334 0.0002942101 1.962812e-01 3.215740e-01 2 85549683 85549829 147 - 1.982 1.943 -0.133
ENSG00000115486 E010 195.1715727 0.0002224359 5.740052e-01 6.998886e-01 2 85549830 85550126 297 - 2.257 2.281 0.079
ENSG00000115486 E011 188.0918678 0.0002373124 2.937938e-01 4.348411e-01 2 85550555 85550744 190 - 2.230 2.267 0.124
ENSG00000115486 E012 70.4995034 0.0003481588 9.386114e-01 9.654476e-01 2 85550745 85550750 6 - 1.824 1.836 0.040
ENSG00000115486 E013 5.8576785 0.0392461963 3.527050e-02 8.216887e-02 2 85550751 85550924 174 - 0.998 0.689 -1.202
ENSG00000115486 E014 177.0176899 0.0002391325 9.311690e-02 1.799945e-01 2 85550925 85551072 148 - 2.194 2.250 0.186
ENSG00000115486 E015 181.4294774 0.0002300741 4.541301e-01 5.947996e-01 2 85551480 85551610 131 - 2.223 2.252 0.098
ENSG00000115486 E016 1.7317508 0.0318694927 3.114189e-01 4.538713e-01 2 85551611 85551811 201 - 0.536 0.362 -0.904
ENSG00000115486 E017 179.5979496 0.0002553189 3.054026e-01 4.475029e-01 2 85551812 85551981 170 - 2.249 2.230 -0.065
ENSG00000115486 E018 1.6531744 0.1799714964 2.149138e-01 3.443343e-01 2 85551982 85552230 249 - 0.584 0.305 -1.476
ENSG00000115486 E019 0.7362571 0.0521337968 3.506412e-01 4.948261e-01 2 85552231 85552304 74 - 0.346 0.181 -1.230
ENSG00000115486 E020 1.6563967 0.0248725854 2.822182e-02 6.845251e-02 2 85552305 85552415 111 - 0.628 0.251 -2.056
ENSG00000115486 E021 137.6626498 0.0030361094 2.565020e-02 6.321769e-02 2 85552416 85552567 152 - 2.171 2.089 -0.274
ENSG00000115486 E022 130.7537721 0.0002622777 2.176496e-07 2.071701e-06 2 85552939 85553070 132 - 2.192 2.039 -0.514
ENSG00000115486 E023 160.3267356 0.0010808008 4.715438e-05 2.673507e-04 2 85553232 85553497 266 - 2.260 2.140 -0.403
ENSG00000115486 E024 1.7338151 0.0082761247 2.405283e-02 5.992157e-02 2 85553498 85554142 645 - 0.628 0.251 -2.052
ENSG00000115486 E025 111.3922958 0.0003495662 1.673608e-04 8.238533e-04 2 85554143 85554306 164 - 2.102 1.981 -0.404
ENSG00000115486 E026 2.7666691 0.0056423411 8.325826e-01 8.950962e-01 2 85554307 85554628 322 - 0.584 0.557 -0.124
ENSG00000115486 E027 0.7384352 0.0162373869 4.238331e-03 1.380925e-02 2 85554629 85554843 215 - 0.481 0.000 -12.203
ENSG00000115486 E028 2.3637125 0.0061753634 3.743944e-06 2.743401e-05 2 85554844 85555483 640 - 0.851 0.101 -4.545
ENSG00000115486 E029 108.1776312 0.0003521073 3.206090e-06 2.383394e-05 2 85555484 85555590 107 - 2.107 1.954 -0.513
ENSG00000115486 E030 3.6921047 0.0367210502 8.703458e-01 9.206070e-01 2 85555591 85556181 591 - 0.668 0.643 -0.106
ENSG00000115486 E031 84.3278894 0.0004057896 2.598965e-08 2.963562e-07 2 85556182 85556217 36 - 2.032 1.825 -0.699
ENSG00000115486 E032 86.3180782 0.0031165667 1.967765e-04 9.500427e-04 2 85556218 85556260 43 - 2.019 1.856 -0.548
ENSG00000115486 E033 21.6971688 0.0008223156 1.934668e-14 6.108617e-13 2 85556261 85558439 2179 - 1.615 1.058 -1.945
ENSG00000115486 E034 111.1288471 0.0024994850 2.011210e-05 1.246623e-04 2 85558440 85558538 99 - 2.129 1.963 -0.555
ENSG00000115486 E035 72.2522296 0.0068705055 4.114163e-04 1.818219e-03 2 85558539 85558565 27 - 1.961 1.766 -0.656
ENSG00000115486 E036 68.7013801 0.0093771576 1.345895e-03 5.129368e-03 2 85558566 85558583 18 - 1.939 1.745 -0.655
ENSG00000115486 E037 64.1397821 0.0191774732 5.148903e-02 1.117949e-01 2 85558584 85558605 22 - 1.885 1.736 -0.504
ENSG00000115486 E038 6.4905171 0.0025903943 9.473886e-04 3.779480e-03 2 85558606 85558662 57 - 1.063 0.668 -1.530
ENSG00000115486 E039 4.0170217 0.0040541119 8.463161e-02 1.668093e-01 2 85558663 85558724 62 - 0.825 0.588 -0.986
ENSG00000115486 E040 194.4667838 0.0020015928 3.413529e-23 3.095657e-21 2 85558725 85558916 192 - 1.998 2.367 1.233
ENSG00000115486 E041 226.6279456 0.0002285558 1.850332e-15 6.756742e-14 2 85558917 85558945 29 - 2.186 2.401 0.717
ENSG00000115486 E042 292.1227818 0.0005479167 1.946178e-17 9.167020e-16 2 85558946 85559005 60 - 2.295 2.512 0.724
ENSG00000115486 E043 311.7737344 0.0023916385 1.709258e-11 3.424790e-10 2 85559006 85559075 70 - 2.320 2.539 0.731
ENSG00000115486 E044 301.8973021 0.0055016866 3.274338e-05 1.930216e-04 2 85560815 85560985 171 - 2.336 2.512 0.588
ENSG00000115486 E045 242.0937841 0.0055915752 8.411409e-05 4.475289e-04 2 85561386 85561532 147 - 2.239 2.416 0.591