ENSG00000115484

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394440 ENSG00000115484 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT4 protein_coding protein_coding 339.7049 260.381 413.7878 36.39903 9.822923 0.6682461 30.49900 23.38721 41.93496 0.8834452 0.5532806 0.8421608 0.09088333 0.09233333 0.10140000 0.009066667 7.391731e-01 1.095105e-13 FALSE TRUE
ENST00000461370 ENSG00000115484 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT4 protein_coding processed_transcript 339.7049 260.381 413.7878 36.39903 9.822923 0.6682461 40.04171 75.76216 18.59938 0.3409512 1.8147550 -2.0256375 0.15522500 0.30243333 0.04503333 -0.257400000 1.095105e-13 1.095105e-13 FALSE FALSE
MSTRG.18473.3 ENSG00000115484 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT4 protein_coding   339.7049 260.381 413.7878 36.39903 9.822923 0.6682461 100.95768 53.65219 146.02391 12.0840996 6.2208682 1.4443255 0.28227500 0.20150000 0.35263333 0.151133333 3.084024e-03 1.095105e-13 TRUE TRUE
MSTRG.18473.5 ENSG00000115484 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT4 protein_coding   339.7049 260.381 413.7878 36.39903 9.822923 0.6682461 96.90727 91.30781 81.71251 27.1092868 7.8719838 -0.1601627 0.28812500 0.33670000 0.19760000 -0.139100000 9.330771e-02 1.095105e-13 FALSE TRUE
MSTRG.18473.8 ENSG00000115484 HEK293_OSMI2_2hA HEK293_TMG_2hB CCT4 protein_coding   339.7049 260.381 413.7878 36.39903 9.822923 0.6682461 68.06825 11.08769 120.84956 3.8323103 3.6815771 3.4450004 0.17434167 0.04813333 0.29220000 0.244066667 3.069810e-03 1.095105e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115484 E001 1.283447 0.3582698116 2.830646e-01 4.231396e-01 2 61868085 61868124 40 - 0.235 0.501 1.597
ENSG00000115484 E002 78.093133 0.0029393489 1.614505e-03 6.006804e-03 2 61868125 61868419 295 - 1.807 1.995 0.633
ENSG00000115484 E003 44.633065 0.0005107532 1.074411e-04 5.563858e-04 2 61868420 61868429 10 - 1.541 1.790 0.846
ENSG00000115484 E004 2139.412908 0.0023097137 1.293374e-17 6.263679e-16 2 61868430 61868706 277 - 3.209 3.454 0.812
ENSG00000115484 E005 2392.450872 0.0039593672 1.069151e-05 7.058634e-05 2 61869440 61869553 114 - 3.292 3.468 0.585
ENSG00000115484 E006 3553.596462 0.0027200869 6.680695e-04 2.781744e-03 2 61872082 61872316 235 - 3.490 3.612 0.407
ENSG00000115484 E007 2627.556822 0.0012725278 4.747166e-04 2.063266e-03 2 61872458 61872581 124 - 3.370 3.471 0.334
ENSG00000115484 E008 1399.805575 0.0007060653 8.723058e-02 1.709425e-01 2 61872582 61872588 7 - 3.113 3.182 0.230
ENSG00000115484 E009 2494.626375 0.0005935107 3.454576e-02 8.079742e-02 2 61873002 61873112 111 - 3.363 3.431 0.226
ENSG00000115484 E010 1768.690182 0.0003431742 2.099237e-01 3.384488e-01 2 61873197 61873291 95 - 3.221 3.276 0.185
ENSG00000115484 E011 755.249609 0.0015554587 3.838585e-01 5.280646e-01 2 61873292 61873293 2 - 2.850 2.905 0.184
ENSG00000115484 E012 2221.601915 0.0011346543 3.940209e-04 1.751639e-03 2 61876095 61876234 140 - 3.351 3.320 -0.103
ENSG00000115484 E013 2139.003244 0.0010962502 7.658847e-17 3.343193e-15 2 61876920 61877052 133 - 3.365 3.250 -0.382
ENSG00000115484 E014 1694.094053 0.0019496210 5.688820e-13 1.450902e-11 2 61877393 61877514 122 - 3.271 3.133 -0.458
ENSG00000115484 E015 2151.166855 0.0004064194 1.376372e-31 2.563909e-29 2 61878869 61879011 143 - 3.366 3.261 -0.350
ENSG00000115484 E016 1615.168449 0.0005745762 5.489918e-17 2.434571e-15 2 61880286 61880394 109 - 3.234 3.151 -0.276
ENSG00000115484 E017 1390.151192 0.0005134177 1.338421e-32 2.726450e-30 2 61883459 61883548 90 - 3.187 3.051 -0.452
ENSG00000115484 E018 1310.189725 0.0036033705 3.054636e-12 6.924634e-11 2 61885020 61885072 53 - 3.175 2.983 -0.638
ENSG00000115484 E019 1.970037 0.0271082677 2.818389e-01 4.217733e-01 2 61886923 61887085 163 - 0.531 0.366 -0.854
ENSG00000115484 E020 403.369395 0.0261767386 8.939214e-27 1.131179e-24 2 61887948 61888257 310 - 2.006 2.927 3.072
ENSG00000115484 E021 2411.214692 0.0102834014 6.267456e-01 7.426466e-01 2 61888381 61888676 296 - 3.376 3.367 -0.029