ENSG00000115459

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393852 ENSG00000115459 HEK293_OSMI2_2hA HEK293_TMG_2hB ELMOD3 protein_coding protein_coding 13.88336 15.38531 10.24909 0.3930855 0.7148228 -0.5855879 1.0988258 2.0079001 0.9881644 0.20763039 0.20189864 -1.01550545 0.07942083 0.13000000 0.09470000 -0.035300000 0.440436435 0.001887994 FALSE  
ENST00000409013 ENSG00000115459 HEK293_OSMI2_2hA HEK293_TMG_2hB ELMOD3 protein_coding protein_coding 13.88336 15.38531 10.24909 0.3930855 0.7148228 -0.5855879 1.0194931 1.7401833 0.5517013 0.38952835 0.27772209 -1.63963109 0.07222917 0.11450000 0.05710000 -0.057400000 0.635623976 0.001887994 FALSE  
ENST00000414593 ENSG00000115459 HEK293_OSMI2_2hA HEK293_TMG_2hB ELMOD3 protein_coding nonsense_mediated_decay 13.88336 15.38531 10.24909 0.3930855 0.7148228 -0.5855879 1.5528598 2.4021412 0.9021739 0.31185178 0.26797965 -1.40293358 0.11191250 0.15563333 0.08906667 -0.066566667 0.274004358 0.001887994 FALSE  
ENST00000446464 ENSG00000115459 HEK293_OSMI2_2hA HEK293_TMG_2hB ELMOD3 protein_coding nonsense_mediated_decay 13.88336 15.38531 10.24909 0.3930855 0.7148228 -0.5855879 0.8542167 0.3809139 0.7664065 0.09239814 0.01735374 0.98996132 0.06282083 0.02500000 0.07553333 0.050533333 0.001887994 0.001887994 TRUE  
ENST00000466467 ENSG00000115459 HEK293_OSMI2_2hA HEK293_TMG_2hB ELMOD3 protein_coding retained_intron 13.88336 15.38531 10.24909 0.3930855 0.7148228 -0.5855879 1.0177805 0.5919919 0.5671188 0.12598572 0.10233182 -0.06087582 0.07646250 0.03830000 0.05460000 0.016300000 0.561538493 0.001887994    
ENST00000476734 ENSG00000115459 HEK293_OSMI2_2hA HEK293_TMG_2hB ELMOD3 protein_coding processed_transcript 13.88336 15.38531 10.24909 0.3930855 0.7148228 -0.5855879 0.9050172 0.4104771 0.6251523 0.21346534 0.44345877 0.59507522 0.06364167 0.02620000 0.05590000 0.029700000 0.936343161 0.001887994    
ENST00000486908 ENSG00000115459 HEK293_OSMI2_2hA HEK293_TMG_2hB ELMOD3 protein_coding retained_intron 13.88336 15.38531 10.24909 0.3930855 0.7148228 -0.5855879 0.9106118 0.9594564 0.7576597 0.17725128 0.31741489 -0.33670909 0.06285000 0.06193333 0.07116667 0.009233333 0.978066961 0.001887994 FALSE  
MSTRG.18762.12 ENSG00000115459 HEK293_OSMI2_2hA HEK293_TMG_2hB ELMOD3 protein_coding   13.88336 15.38531 10.24909 0.3930855 0.7148228 -0.5855879 3.1252913 2.4556065 2.7733844 0.63720227 0.50964695 0.17489756 0.23671250 0.16186667 0.27083333 0.108966667 0.408657051 0.001887994 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115459 E001 0.0000000       2 85354394 85354719 326 +      
ENSG00000115459 E002 0.0000000       2 85354720 85354725 6 +      
ENSG00000115459 E003 1.0987104 0.0719573008 1.587772e-02 4.246288e-02 2 85354726 85354745 20 + 0.542 0.099 -3.273
ENSG00000115459 E004 2.1650642 0.0409380425 2.896760e-01 4.303872e-01 2 85354746 85354750 5 + 0.591 0.405 -0.912
ENSG00000115459 E005 2.1650642 0.0409380425 2.896760e-01 4.303872e-01 2 85354751 85354752 2 + 0.591 0.405 -0.912
ENSG00000115459 E006 3.1667868 0.0049876756 1.969976e-01 3.224632e-01 2 85354753 85354756 4 + 0.711 0.519 -0.849
ENSG00000115459 E007 4.4610304 0.0114442068 2.327781e-01 3.657342e-01 2 85354757 85354768 12 + 0.805 0.637 -0.692
ENSG00000115459 E008 5.5628863 0.0031150447 2.202128e-01 3.506792e-01 2 85354769 85354778 10 + 0.883 0.728 -0.609
ENSG00000115459 E009 28.1390480 0.0007105690 1.160096e-02 3.258515e-02 2 85354779 85354802 24 + 1.539 1.380 -0.546
ENSG00000115459 E010 30.2665640 0.0006729615 1.091806e-03 4.276254e-03 2 85354803 85354805 3 + 1.592 1.394 -0.682
ENSG00000115459 E011 39.1892765 0.0005905057 5.863514e-03 1.825424e-02 2 85354806 85354829 24 + 1.672 1.524 -0.503
ENSG00000115459 E012 1.2209898 0.0108647759 1.734108e-01 2.926253e-01 2 85355075 85355075 1 + 0.151 0.404 1.887
ENSG00000115459 E013 29.1081796 0.0007142223 5.526388e-01 6.819074e-01 2 85355076 85355170 95 + 1.477 1.445 -0.113
ENSG00000115459 E014 6.7685729 0.0027836096 1.521222e-07 1.491671e-06 2 85355171 85355554 384 + 1.179 0.551 -2.464
ENSG00000115459 E015 41.1272183 0.0005126331 1.744830e-02 4.592989e-02 2 85355555 85355598 44 + 1.680 1.556 -0.420
ENSG00000115459 E016 42.7243931 0.0005302488 4.825577e-08 5.221861e-07 2 85355599 85355716 118 + 1.780 1.497 -0.962
ENSG00000115459 E017 31.0199099 0.0150859318 2.686339e-03 9.333164e-03 2 85355717 85355784 68 + 1.624 1.376 -0.851
ENSG00000115459 E018 36.4470000 0.0006152566 6.413770e-04 2.685236e-03 2 85355785 85355896 112 + 1.668 1.479 -0.646
ENSG00000115459 E019 9.0720655 0.0019353914 7.368382e-01 8.271909e-01 2 85355897 85355916 20 + 1.005 0.974 -0.113
ENSG00000115459 E020 37.1909005 0.0012918334 1.094846e-02 3.103765e-02 2 85355917 85356533 617 + 1.644 1.501 -0.490
ENSG00000115459 E021 5.8071413 0.0386455659 1.150927e-04 5.913423e-04 2 85356534 85356601 68 + 1.100 0.520 -2.325
ENSG00000115459 E022 6.3292489 0.0049835025 5.818244e-03 1.813357e-02 2 85356602 85356667 66 + 1.039 0.706 -1.283
ENSG00000115459 E023 7.9588031 0.0024361988 1.804010e-03 6.611934e-03 2 85356668 85356966 299 + 1.128 0.786 -1.283
ENSG00000115459 E024 74.9621853 0.0013901187 3.479678e-02 8.125610e-02 2 85356967 85357079 113 + 1.911 1.824 -0.291
ENSG00000115459 E025 77.0787634 0.0030330861 1.321485e-01 2.370913e-01 2 85357080 85357190 111 + 1.913 1.848 -0.220
ENSG00000115459 E026 27.4196732 0.0040960499 5.049904e-01 6.408329e-01 2 85357191 85357197 7 + 1.459 1.416 -0.149
ENSG00000115459 E027 44.4326529 0.0020104292 2.912993e-01 4.321518e-01 2 85357198 85357252 55 + 1.668 1.614 -0.184
ENSG00000115459 E028 7.7292746 0.1010473165 2.156684e-01 3.452073e-01 2 85357253 85357578 326 + 1.039 0.848 -0.719
ENSG00000115459 E029 52.7464776 0.0004940815 3.336875e-01 4.774270e-01 2 85362186 85362232 47 + 1.668 1.723 0.187
ENSG00000115459 E030 53.1619096 0.0039269960 4.183155e-01 5.615968e-01 2 85362233 85362260 28 + 1.672 1.724 0.176
ENSG00000115459 E031 62.9543485 0.0155785194 7.822740e-01 8.602145e-01 2 85363097 85363166 70 + 1.797 1.774 -0.078
ENSG00000115459 E032 67.7122916 0.0009318862 1.827996e-01 3.047175e-01 2 85368686 85368754 69 + 1.768 1.835 0.228
ENSG00000115459 E033 71.1046217 0.0009621819 3.212574e-03 1.089279e-02 2 85369739 85369830 92 + 1.733 1.875 0.479
ENSG00000115459 E034 82.5892839 0.0004014248 8.186026e-03 2.425541e-02 2 85371086 85371209 124 + 1.817 1.932 0.388
ENSG00000115459 E035 2.1894161 0.1427085539 7.153314e-01 8.112724e-01 2 85371210 85371439 230 + 0.544 0.447 -0.471
ENSG00000115459 E036 62.8205025 0.0006852007 1.088305e-04 5.627267e-04 2 85371440 85371562 123 + 1.649 1.843 0.658
ENSG00000115459 E037 0.4418608 0.0248919507 3.196998e-02 7.580246e-02 2 85371563 85372909 1347 + 0.351 0.000 -10.895
ENSG00000115459 E038 0.4438354 0.0947356825 9.126795e-01 9.486585e-01 2 85376882 85376916 35 + 0.151 0.178 0.287
ENSG00000115459 E039 85.3928655 0.0005873004 2.323248e-01 3.652005e-01 2 85377344 85377474 131 + 1.879 1.933 0.185
ENSG00000115459 E040 1.2586699 0.0143530879 1.652302e-01 2.819818e-01 2 85377945 85378023 79 + 0.488 0.247 -1.436
ENSG00000115459 E041 10.7953401 0.0679139515 7.268799e-01 8.197873e-01 2 85387098 85387225 128 + 1.005 1.060 0.201
ENSG00000115459 E042 9.6115163 0.0268055859 9.385536e-01 9.654091e-01 2 85389548 85389750 203 + 1.005 0.998 -0.027
ENSG00000115459 E043 76.2388670 0.0074303443 4.338689e-01 5.762581e-01 2 85389751 85389827 77 + 1.828 1.882 0.179
ENSG00000115459 E044 99.1297933 0.0010979091 9.509034e-02 1.830132e-01 2 85390138 85390265 128 + 1.928 2.000 0.243
ENSG00000115459 E045 28.9246308 0.0138824534 5.720082e-01 6.981802e-01 2 85390266 85390759 494 + 1.413 1.466 0.185
ENSG00000115459 E046 284.1055530 0.0017985652 5.231162e-12 1.139899e-10 2 85390760 85391752 993 + 2.292 2.490 0.662