ENSG00000115419

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320717 ENSG00000115419 HEK293_OSMI2_2hA HEK293_TMG_2hB GLS protein_coding protein_coding 21.75326 6.766251 32.36887 1.880504 1.2002 2.256494 3.6749902 1.545857 3.583711 0.0964412 0.04079949 1.207765 0.21944583 0.2551 0.11113333 -0.14396667 2.809338e-02 4.529464e-14 FALSE TRUE
ENST00000338435 ENSG00000115419 HEK293_OSMI2_2hA HEK293_TMG_2hB GLS protein_coding protein_coding 21.75326 6.766251 32.36887 1.880504 1.2002 2.256494 11.1807726 1.790321 21.143516 0.2598152 0.92348405 3.554571 0.42577500 0.2830 0.65573333 0.37273333 1.008006e-05 4.529464e-14 FALSE TRUE
ENST00000409215 ENSG00000115419 HEK293_OSMI2_2hA HEK293_TMG_2hB GLS protein_coding protein_coding 21.75326 6.766251 32.36887 1.880504 1.2002 2.256494 0.5778224 2.664648 0.000000 1.5330816 0.00000000 -8.063205 0.08888333 0.3356 0.00000000 -0.33560000 4.529464e-14 4.529464e-14 FALSE FALSE
ENST00000469774 ENSG00000115419 HEK293_OSMI2_2hA HEK293_TMG_2hB GLS protein_coding retained_intron 21.75326 6.766251 32.36887 1.880504 1.2002 2.256494 2.9915436 0.000000 3.266902 0.0000000 1.73215042 8.356189 0.07586250 0.0000 0.09793333 0.09793333 3.491718e-01 4.529464e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115419 E001 9.6251140 0.0026115199 5.071289e-02 1.104337e-01 2 190880821 190880833 13 + 0.919 0.723 -0.770
ENSG00000115419 E002 30.4774243 0.0088295263 5.926718e-02 1.253837e-01 2 190880834 190880871 38 + 1.369 1.296 -0.253
ENSG00000115419 E003 71.9468393 0.0110396760 1.612604e-03 6.000846e-03 2 190880872 190881154 283 + 1.739 1.594 -0.490
ENSG00000115419 E004 78.6143169 0.0080634797 8.695294e-05 4.607696e-04 2 190881155 190881470 316 + 1.780 1.587 -0.652
ENSG00000115419 E005 76.1005904 0.0083408240 1.165621e-01 2.150431e-01 2 190895152 190895248 97 + 1.743 1.739 -0.016
ENSG00000115419 E006 0.1472490 0.0469199660 1.000000e+00   2 190895249 190895603 355 + 0.051 0.000 -7.917
ENSG00000115419 E007 75.9906437 0.0037649791 7.795983e-02 1.562008e-01 2 190895604 190895651 48 + 1.742 1.746 0.013
ENSG00000115419 E008 95.8443840 0.0003083719 4.729092e-02 1.043506e-01 2 190895652 190895725 74 + 1.838 1.863 0.085
ENSG00000115419 E009 17.7702470 0.0010507212 9.838313e-01 9.939573e-01 2 190895726 190896568 843 + 1.122 1.237 0.409
ENSG00000115419 E010 136.1236488 0.0002760751 2.923199e-03 1.003972e-02 2 190900564 190900663 100 + 1.992 1.990 -0.006
ENSG00000115419 E011 110.8623678 0.0002983840 3.291726e-02 7.763846e-02 2 190900664 190900693 30 + 1.899 1.924 0.084
ENSG00000115419 E012 154.9452874 0.0062843196 1.518442e-02 4.090556e-02 2 190901947 190902026 80 + 2.050 2.023 -0.090
ENSG00000115419 E013 211.5277685 0.0002317664 3.642035e-08 4.033265e-07 2 190905004 190905167 164 + 2.191 2.123 -0.227
ENSG00000115419 E014 0.1817044 0.0749550785 7.206426e-02   2 190905168 190905276 109 + 0.000 0.269 13.225
ENSG00000115419 E015 134.0569581 0.0002227460 1.666790e-04 8.209237e-04 2 190910263 190910321 59 + 1.992 1.954 -0.126
ENSG00000115419 E016 4.1511249 0.0041245108 7.423971e-01 8.312936e-01 2 190913193 190913364 172 + 0.571 0.723 0.653
ENSG00000115419 E017 1.0309706 0.0139244738 2.705576e-01 4.092191e-01 2 190920045 190920214 170 + 0.271 0.000 -10.724
ENSG00000115419 E018 0.4375944 0.0286072665 1.000000e+00 1.000000e+00 2 190920215 190920248 34 + 0.137 0.000 -9.501
ENSG00000115419 E019 90.3430369 0.0003376334 1.175470e-04 6.026052e-04 2 190921024 190921026 3 + 1.829 1.746 -0.279
ENSG00000115419 E020 102.0225217 0.0002878421 1.447788e-03 5.466162e-03 2 190921027 190921056 30 + 1.874 1.842 -0.109
ENSG00000115419 E021 114.2127054 0.0002836230 1.313434e-02 3.621927e-02 2 190921145 190921203 59 + 1.917 1.929 0.039
ENSG00000115419 E022 121.9280619 0.0015327354 2.743923e-03 9.503950e-03 2 190923917 190923983 67 + 1.948 1.924 -0.082
ENSG00000115419 E023 109.2471835 0.0002746067 1.590182e-02 4.251474e-02 2 190924543 190924593 51 + 1.895 1.906 0.037
ENSG00000115419 E024 1.8498430 0.0075885325 4.397354e-01 5.814817e-01 2 190924594 190924780 187 + 0.325 0.552 1.205
ENSG00000115419 E025 1.4737619 0.0093037924 5.936794e-01 7.160369e-01 2 190927004 190927015 12 + 0.325 0.268 -0.380
ENSG00000115419 E026 2.4294896 0.0069154776 6.853564e-01 7.881289e-01 2 190927016 190927305 290 + 0.436 0.433 -0.016
ENSG00000115419 E027 214.2482780 0.0002387045 4.195934e-05 2.406549e-04 2 190927306 190927482 177 + 2.189 2.176 -0.045
ENSG00000115419 E028 0.8126314 0.0144751820 8.251814e-01 8.898763e-01 2 190927483 190927611 129 + 0.175 0.269 0.792
ENSG00000115419 E029 0.2214452 0.0608746882 7.145474e-02   2 190927672 190927692 21 + 0.000 0.269 13.230
ENSG00000115419 E030 0.0000000       2 190927693 190927730 38 +      
ENSG00000115419 E031 99.7595647 0.0002913454 1.161013e-04 5.960557e-04 2 190930437 190930448 12 + 1.868 1.797 -0.242
ENSG00000115419 E032 182.0388634 0.0002662415 1.168177e-06 9.563853e-06 2 190930449 190930568 120 + 2.126 2.069 -0.190
ENSG00000115419 E033 84.3034142 0.0037626259 9.364208e-04 3.741398e-03 2 190931545 190931562 18 + 1.799 1.717 -0.279
ENSG00000115419 E034 139.4331451 0.0032744570 7.696626e-05 4.137283e-04 2 190931563 190931637 75 + 2.014 1.935 -0.266
ENSG00000115419 E035 7.0780246 0.0024131859 2.825149e-01 4.225191e-01 2 190932657 190932715 59 + 0.792 0.723 -0.280
ENSG00000115419 E036 771.5381532 0.0314190933 1.081583e-02 3.072326e-02 2 190932716 190935289 2574 + 2.675 2.998 1.072
ENSG00000115419 E037 10.1338917 0.0059508728 4.638132e-02 1.027288e-01 2 190953565 190953626 62 + 0.841 1.192 1.293
ENSG00000115419 E038 12.4150961 0.0098717703 2.329057e-03 8.240403e-03 2 190954584 190954660 77 + 0.885 1.334 1.623
ENSG00000115419 E039 10.7481034 0.0553159965 1.272536e-02 3.526647e-02 2 190954755 190954818 64 + 0.826 1.284 1.677
ENSG00000115419 E040 170.1646254 0.0162598977 8.482948e-20 5.260455e-18 2 190962830 190965552 2723 + 1.891 2.576 2.293