ENSG00000115415

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361099 ENSG00000115415 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT1 protein_coding protein_coding 12.74729 8.257969 17.28834 0.9059277 0.5179266 1.065029 8.8585942 3.5320985 13.67829778 0.1192313 1.11578809 1.9502668 0.64032917 0.43436667 0.793833333 0.35946667 0.0057723220 0.0006009509 FALSE TRUE
ENST00000392322 ENSG00000115415 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT1 protein_coding protein_coding 12.74729 8.257969 17.28834 0.9059277 0.5179266 1.065029 0.6509534 0.6212576 0.41775923 0.3181252 0.21055405 -0.5614298 0.06185000 0.07323333 0.024433333 -0.04880000 0.8186506065 0.0006009509 FALSE TRUE
ENST00000673734 ENSG00000115415 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT1 protein_coding nonsense_mediated_decay 12.74729 8.257969 17.28834 0.9059277 0.5179266 1.065029 0.4835962 0.0000000 1.35752309 0.0000000 1.35752309 7.0954214 0.02565000 0.00000000 0.076500000 0.07650000 0.9519864814 0.0006009509 FALSE TRUE
ENST00000673762 ENSG00000115415 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT1 protein_coding processed_transcript 12.74729 8.257969 17.28834 0.9059277 0.5179266 1.065029 1.1129058 3.0056149 0.07701083 1.2480477 0.07701083 -5.1151135 0.14040417 0.34216667 0.004333333 -0.33783333 0.0006009509 0.0006009509 FALSE TRUE
ENST00000673863 ENSG00000115415 HEK293_OSMI2_2hA HEK293_TMG_2hB STAT1 protein_coding nonsense_mediated_decay 12.74729 8.257969 17.28834 0.9059277 0.5179266 1.065029 0.2162216 0.4317682 0.00000000 0.4317682 0.00000000 -5.4652178 0.02499583 0.06036667 0.000000000 -0.06036667 0.7220626585 0.0006009509 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115415 E001 0.0000000       2 190908460 190909000 541 -      
ENSG00000115415 E002 0.6611159 0.0303697563 8.754951e-01 9.240363e-01 2 190944703 190945657 955 - 0.207 0.182 -0.227
ENSG00000115415 E003 0.5483223 0.0226677801 1.829433e-01 3.048765e-01 2 190964352 190964694 343 - 0.080 0.310 2.357
ENSG00000115415 E004 2.0250142 0.0296779141 2.519526e-02 6.227252e-02 2 190969149 190969149 1 - 0.305 0.710 2.022
ENSG00000115415 E005 2.0250142 0.0296779141 2.519526e-02 6.227252e-02 2 190969150 190969150 1 - 0.305 0.710 2.022
ENSG00000115415 E006 21.6169421 0.0172203801 1.179773e-04 6.045729e-04 2 190969151 190969266 116 - 1.165 1.565 1.390
ENSG00000115415 E007 16.2811883 0.0153862376 6.521167e-04 2.723399e-03 2 190969267 190969267 1 - 1.064 1.435 1.308
ENSG00000115415 E008 24.4902659 0.0008739521 1.739088e-14 5.539090e-13 2 190969268 190969311 44 - 1.121 1.679 1.938
ENSG00000115415 E009 18.7969635 0.0109005812 1.769781e-13 4.864061e-12 2 190969312 190969317 6 - 0.910 1.620 2.515
ENSG00000115415 E010 373.2149047 0.0046648240 1.146979e-11 2.363922e-10 2 190969318 190970290 973 - 2.446 2.702 0.853
ENSG00000115415 E011 128.9751702 0.0002408408 7.880375e-01 8.642434e-01 2 190970291 190970497 207 - 2.076 2.109 0.110
ENSG00000115415 E012 73.9786822 0.0003213411 8.611470e-01 9.144305e-01 2 190970498 190970576 79 - 1.843 1.859 0.055
ENSG00000115415 E013 101.5555817 0.0003437416 4.885130e-01 6.260600e-01 2 190970577 190970717 141 - 1.985 1.983 -0.007
ENSG00000115415 E014 2.1746317 0.0065958403 1.927708e-01 3.172502e-01 2 190974049 190974829 781 - 0.537 0.310 -1.230
ENSG00000115415 E015 82.1171865 0.0003637268 3.634880e-01 5.078918e-01 2 190974830 190974932 103 - 1.872 1.933 0.206
ENSG00000115415 E016 1.1698006 0.1764715545 8.106920e-02 1.612168e-01 2 190975310 190975388 79 - 0.419 0.000 -13.302
ENSG00000115415 E017 0.7342825 0.0159807465 1.317402e-01 2.365453e-01 2 190975389 190975434 46 - 0.305 0.000 -12.629
ENSG00000115415 E018 0.5117019 0.0325020955 1.358236e-02 3.726538e-02 2 190975536 190975536 1 - 0.000 0.408 14.324
ENSG00000115415 E019 0.5117019 0.0325020955 1.358236e-02 3.726538e-02 2 190975537 190975537 1 - 0.000 0.408 14.324
ENSG00000115415 E020 1.0223597 0.3240124730 4.539142e-02 1.009114e-01 2 190975538 190975568 31 - 0.080 0.555 3.672
ENSG00000115415 E021 2.6046714 0.0087965386 7.091700e-03 2.146683e-02 2 190975569 190975641 73 - 0.347 0.792 2.090
ENSG00000115415 E022 9.8548212 0.0360977914 3.090884e-05 1.833366e-04 2 190975642 190975811 170 - 0.738 1.322 2.158
ENSG00000115415 E023 92.9079275 0.0019886849 1.675684e-02 4.440030e-02 2 190975812 190975887 76 - 1.901 2.027 0.423
ENSG00000115415 E024 122.5665284 0.0002951530 2.248737e-02 5.669787e-02 2 190976840 190977025 186 - 2.030 2.131 0.337
ENSG00000115415 E025 0.2965864 0.0807724472 5.919765e-02   2 190977026 190977041 16 - 0.000 0.308 13.728
ENSG00000115415 E026 0.0000000       2 190978491 190978527 37 -      
ENSG00000115415 E027 0.1515154 0.0434801628 1.000000e+00   2 190978528 190978606 79 - 0.080 0.000 -10.308
ENSG00000115415 E028 0.0000000       2 190978607 190978855 249 -      
ENSG00000115415 E029 76.1805202 0.0018444704 3.071282e-01 4.493013e-01 2 190978856 190979001 146 - 1.836 1.908 0.243
ENSG00000115415 E030 0.4804688 0.0214958654 8.761513e-01 9.244766e-01 2 190979002 190979106 105 - 0.148 0.182 0.354
ENSG00000115415 E031 45.7840428 0.0005160348 3.245218e-01 4.678855e-01 2 190979772 190979866 95 - 1.620 1.698 0.264
ENSG00000115415 E032 0.2966881 0.0269422831 5.814443e-01   2 190980155 190980285 131 - 0.148 0.000 -11.308
ENSG00000115415 E033 58.8530659 0.0006858094 1.364640e-01 2.431323e-01 2 190980620 190980669 50 - 1.713 1.809 0.325
ENSG00000115415 E034 0.2966881 0.0269422831 5.814443e-01   2 190982188 190982382 195 - 0.148 0.000 -11.308
ENSG00000115415 E035 81.0220628 0.0066646825 5.232209e-01 6.569460e-01 2 190982383 190982518 136 - 1.865 1.919 0.180
ENSG00000115415 E036 85.5717919 0.0030380498 3.359102e-01 4.797314e-01 2 190983642 190983740 99 - 1.915 1.890 -0.086
ENSG00000115415 E037 0.3268771 0.0307865373 5.146658e-01   2 190983741 190983758 18 - 0.080 0.182 1.355
ENSG00000115415 E038 75.0319993 0.0003417706 8.131675e-02 1.616124e-01 2 190984310 190984393 84 - 1.870 1.816 -0.180
ENSG00000115415 E039 56.8766860 0.0003959604 3.035995e-02 7.267320e-02 2 190985619 190985660 42 - 1.762 1.675 -0.295
ENSG00000115415 E040 74.5247121 0.0003263145 1.786242e-04 8.720254e-04 2 190986854 190986941 88 - 1.893 1.745 -0.498
ENSG00000115415 E041 35.9107618 0.0007459611 1.074048e-02 3.054587e-02 2 190986942 190986947 6 - 1.583 1.440 -0.490
ENSG00000115415 E042 48.1967977 0.0111158216 1.302070e-02 3.596029e-02 2 190987039 190987068 30 - 1.710 1.542 -0.570
ENSG00000115415 E043 0.1451727 0.0431386969 1.000000e+00   2 190988560 190989614 1055 - 0.080 0.000 -10.307
ENSG00000115415 E044 57.6974438 0.0004539085 5.755480e-06 4.040909e-05 2 190989615 190989674 60 - 1.798 1.579 -0.744
ENSG00000115415 E045 60.0630377 0.0005827888 1.614692e-04 7.983154e-04 2 190991228 190991320 93 - 1.807 1.635 -0.583
ENSG00000115415 E046 67.3130184 0.0003698536 1.089584e-02 3.091437e-02 2 190995061 190995208 148 - 1.837 1.741 -0.326
ENSG00000115415 E047 27.9457694 0.0058033599 8.133758e-01 8.816743e-01 2 190995209 190995219 11 - 1.439 1.446 0.025
ENSG00000115415 E048 81.0770931 0.0003389271 3.153740e-01 4.581413e-01 2 190997856 190998007 152 - 1.893 1.874 -0.063
ENSG00000115415 E049 79.0580884 0.0035655932 1.466034e-02 3.972795e-02 2 190998217 190998308 92 - 1.903 1.796 -0.360
ENSG00000115415 E050 74.4707682 0.0016477775 1.552492e-05 9.873271e-05 2 190999626 190999704 79 - 1.901 1.707 -0.654
ENSG00000115415 E051 46.7854713 0.0004938303 1.046656e-03 4.120395e-03 2 191001074 191001085 12 - 1.696 1.529 -0.570
ENSG00000115415 E052 89.7031318 0.0050445741 1.091615e-02 3.096041e-02 2 191001086 191001163 78 - 1.960 1.844 -0.389
ENSG00000115415 E053 87.7816710 0.0052320801 8.333835e-03 2.462750e-02 2 191007563 191007661 99 - 1.953 1.828 -0.420
ENSG00000115415 E054 68.0124420 0.0141150789 1.630813e-01 2.791606e-01 2 191008963 191009026 64 - 1.834 1.745 -0.301
ENSG00000115415 E055 70.7501769 0.0077331343 1.050392e-02 2.998789e-02 2 191009027 191009107 81 - 1.866 1.722 -0.484
ENSG00000115415 E056 80.2063581 0.0013877305 3.993395e-04 1.771790e-03 2 191009876 191010004 129 - 1.921 1.777 -0.487
ENSG00000115415 E057 1.8101022 0.0076867179 7.418976e-01 8.309308e-01 2 191010367 191010449 83 - 0.452 0.408 -0.232
ENSG00000115415 E058 0.1451727 0.0431386969 1.000000e+00   2 191013521 191013524 4 - 0.080 0.000 -10.307
ENSG00000115415 E059 64.3274585 0.0007765801 1.966742e-04 9.496878e-04 2 191013525 191013678 154 - 1.835 1.670 -0.558
ENSG00000115415 E060 0.1472490 0.0442457042 1.000000e+00   2 191013679 191013955 277 - 0.080 0.000 -10.308
ENSG00000115415 E061 32.7649660 0.0006765702 2.532866e-03 8.862039e-03 2 191014018 191014078 61 - 1.554 1.369 -0.638
ENSG00000115415 E062 26.6856478 0.0246626149 5.702249e-02 1.214979e-01 2 191014079 191014231 153 - 1.466 1.283 -0.638
ENSG00000115415 E063 0.0000000       2 191020200 191020320 121 -      
ENSG00000115415 E064 0.0000000       2 191020758 191020960 203 -