ENSG00000115365

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000431941 ENSG00000115365 HEK293_OSMI2_2hA HEK293_TMG_2hB LANCL1 protein_coding protein_coding 18.34856 6.323369 31.61618 1.809326 0.2324788 2.320074 3.2642580 0.2261215 7.098556 0.1045737 0.9204112 4.911955 0.1189667 0.0326000 0.2249667 0.19236667 2.493360e-07 7.481063e-45 FALSE TRUE
ENST00000441020 ENSG00000115365 HEK293_OSMI2_2hA HEK293_TMG_2hB LANCL1 protein_coding protein_coding 18.34856 6.323369 31.61618 1.809326 0.2324788 2.320074 0.6141395 2.5500150 0.000000 0.8600849 0.0000000 -8.000008 0.0956750 0.3933000 0.0000000 -0.39330000 7.481063e-45 7.481063e-45 FALSE TRUE
ENST00000450366 ENSG00000115365 HEK293_OSMI2_2hA HEK293_TMG_2hB LANCL1 protein_coding protein_coding 18.34856 6.323369 31.61618 1.809326 0.2324788 2.320074 11.4976243 2.6227261 19.786961 0.6704904 0.6010655 2.910650 0.6379708 0.4222000 0.6257000 0.20350000 3.436645e-05 7.481063e-45 FALSE TRUE
MSTRG.19893.1 ENSG00000115365 HEK293_OSMI2_2hA HEK293_TMG_2hB LANCL1 protein_coding   18.34856 6.323369 31.61618 1.809326 0.2324788 2.320074 2.2512700 0.8439313 3.795366 0.2442492 0.7126725 2.155843 0.1072125 0.1363667 0.1198000 -0.01656667 8.960592e-01 7.481063e-45 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115365 E001 0.5870335 0.1347052713 5.045620e-01 6.404797e-01 2 210431249 210431250 2 - 0.209 0.000 -9.947
ENSG00000115365 E002 1156.5148862 0.0015477357 2.002417e-23 1.858169e-21 2 210431251 210434114 2864 - 2.935 3.120 0.615
ENSG00000115365 E003 85.2876825 0.0230606783 5.617749e-01 6.895135e-01 2 210434115 210434238 124 - 1.859 1.839 -0.066
ENSG00000115365 E004 155.0854901 0.0002500975 6.113763e-02 1.285498e-01 2 210434239 210434486 248 - 2.116 2.105 -0.036
ENSG00000115365 E005 96.7946377 0.0002674507 3.937257e-02 8.986089e-02 2 210434487 210434520 34 - 1.919 1.882 -0.124
ENSG00000115365 E006 93.7894934 0.0002770596 2.081124e-02 5.319463e-02 2 210434521 210434563 43 - 1.908 1.858 -0.169
ENSG00000115365 E007 106.8844651 0.0002955347 1.975179e-02 5.096391e-02 2 210435387 210435459 73 - 1.963 1.919 -0.149
ENSG00000115365 E008 157.0868132 0.0002295135 3.686921e-03 1.225848e-02 2 210436216 210436392 177 - 2.128 2.081 -0.157
ENSG00000115365 E009 165.6927631 0.0030504047 2.937553e-02 7.072729e-02 2 210437690 210437872 183 - 2.150 2.101 -0.164
ENSG00000115365 E010 114.0537319 0.0049215635 2.371636e-02 5.922822e-02 2 210440598 210440698 101 - 1.994 1.914 -0.268
ENSG00000115365 E011 76.1499790 0.0003791438 2.306867e-03 8.173503e-03 2 210440699 210440744 46 - 1.827 1.724 -0.348
ENSG00000115365 E012 0.2987644 0.0277341479 1.000000e+00   2 210440745 210440745 1 - 0.117 0.000 -11.301
ENSG00000115365 E013 119.5549040 0.0002828495 2.569885e-05 1.553369e-04 2 210441308 210441443 136 - 2.025 1.905 -0.403
ENSG00000115365 E014 112.4858734 0.0003075666 3.105657e-04 1.422562e-03 2 210455107 210455258 152 - 1.995 1.897 -0.329
ENSG00000115365 E015 57.8638779 0.0003853500 4.370272e-01 5.790605e-01 2 210455259 210455314 56 - 1.690 1.701 0.035
ENSG00000115365 E016 0.2903454 0.3892742360 1.000000e+00   2 210468148 210468241 94 - 0.117 0.000 -10.121
ENSG00000115365 E017 0.0000000       2 210471507 210471645 139 -      
ENSG00000115365 E018 108.4850228 0.0027800642 1.109482e-02 3.139348e-02 2 210471959 210472076 118 - 1.975 1.902 -0.244
ENSG00000115365 E019 86.6048962 0.0053405580 2.256058e-03 8.018027e-03 2 210476316 210476412 97 - 1.888 1.753 -0.457
ENSG00000115365 E020 5.0835606 0.0033255899 6.850739e-02 1.409039e-01 2 210476413 210476619 207 - 0.763 0.484 -1.227
ENSG00000115365 E021 31.1473606 0.0014143476 1.307400e-02 3.608224e-02 2 210476620 210476646 27 - 1.456 1.304 -0.526
ENSG00000115365 E022 25.0786516 0.0054953852 1.020179e-02 2.926291e-02 2 210476647 210476708 62 - 1.373 1.166 -0.726
ENSG00000115365 E023 4.7359458 0.0035070836 2.888903e-04 1.334701e-03 2 210476709 210476721 13 - 0.775 0.000 -15.682
ENSG00000115365 E024 11.2118459 0.0183236371 1.972532e-02 5.090733e-02 2 210476722 210476775 54 - 1.062 0.761 -1.143
ENSG00000115365 E025 9.3056583 0.0020737652 8.853251e-01 9.306610e-01 2 210477450 210477652 203 - 0.934 0.964 0.112