ENSG00000115325

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340004 ENSG00000115325 HEK293_OSMI2_2hA HEK293_TMG_2hB DOK1 protein_coding protein_coding 10.51191 19.22444 6.090981 1.027321 0.3310881 -1.656579 0.881124 1.443979 1.0875043 0.1480746 0.17862840 -0.4057803 0.0856000 0.07516667 0.17773333 0.10256667 0.002038938 0.002038938 FALSE TRUE
ENST00000409429 ENSG00000115325 HEK293_OSMI2_2hA HEK293_TMG_2hB DOK1 protein_coding protein_coding 10.51191 19.22444 6.090981 1.027321 0.3310881 -1.656579 3.361952 4.599342 2.4302667 1.4350891 0.28903848 -0.9175220 0.3430417 0.23303333 0.40196667 0.16893333 0.316181514 0.002038938 FALSE TRUE
ENST00000464613 ENSG00000115325 HEK293_OSMI2_2hA HEK293_TMG_2hB DOK1 protein_coding retained_intron 10.51191 19.22444 6.090981 1.027321 0.3310881 -1.656579 2.382227 6.908051 0.5005468 1.4416202 0.50054684 -3.7602504 0.2079417 0.36736667 0.07863333 -0.28873333 0.105863467 0.002038938 FALSE TRUE
ENST00000488613 ENSG00000115325 HEK293_OSMI2_2hA HEK293_TMG_2hB DOK1 protein_coding processed_transcript 10.51191 19.22444 6.090981 1.027321 0.3310881 -1.656579 1.307643 2.298087 0.5972278 0.3055326 0.08305802 -1.9263881 0.1207500 0.11853333 0.09746667 -0.02106667 0.639970157 0.002038938   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115325 E001 4.478343 0.0039440114 0.39047966 0.53444883 2 74549017 74549025 9 + 0.745 0.638 -0.448
ENSG00000115325 E002 7.561594 0.0144327025 0.20449542 0.33178917 2 74549026 74549046 21 + 0.953 0.808 -0.557
ENSG00000115325 E003 12.047525 0.0254262918 0.24525332 0.38033828 2 74549047 74549070 24 + 1.113 0.995 -0.428
ENSG00000115325 E004 26.868465 0.0044018638 0.10555362 0.19893766 2 74549071 74549172 102 + 1.426 1.326 -0.347
ENSG00000115325 E005 9.651531 0.0018312461 0.26152905 0.39917736 2 74549413 74549571 159 + 1.029 0.926 -0.385
ENSG00000115325 E006 20.390321 0.0009431294 0.36554793 0.50985414 2 74554160 74554547 388 + 1.150 1.262 0.397
ENSG00000115325 E007 3.728660 0.0106187411 0.57117045 0.69751712 2 74554720 74554721 2 + 0.516 0.637 0.548
ENSG00000115325 E008 5.416488 0.0030920864 0.59683046 0.71871165 2 74554722 74554730 9 + 0.646 0.752 0.440
ENSG00000115325 E009 5.155302 0.0033221078 0.66483877 0.77260086 2 74554731 74554733 3 + 0.646 0.737 0.381
ENSG00000115325 E010 5.558452 0.0029797072 0.53417649 0.66628266 2 74554734 74554737 4 + 0.646 0.766 0.497
ENSG00000115325 E011 5.888450 0.0029081045 0.42341291 0.56646138 2 74554738 74554741 4 + 0.646 0.792 0.603
ENSG00000115325 E012 6.922424 0.0024606188 0.61672467 0.73472458 2 74554742 74554749 8 + 0.745 0.841 0.381
ENSG00000115325 E013 9.114482 0.0019125752 0.83707284 0.89810945 2 74554750 74554793 44 + 0.925 0.926 0.003
ENSG00000115325 E014 10.946352 0.0047120688 0.25582119 0.39275312 2 74554794 74554814 21 + 1.073 0.971 -0.373
ENSG00000115325 E015 3.426776 0.0113662210 0.85917157 0.91314152 2 74554815 74554859 45 + 0.586 0.578 -0.034
ENSG00000115325 E016 2.133641 0.0548594559 0.26766901 0.40600078 2 74555132 74555153 22 + 0.585 0.395 -0.945
ENSG00000115325 E017 20.097720 0.0209908501 0.04814436 0.10588473 2 74555154 74555155 2 + 1.366 1.191 -0.615
ENSG00000115325 E018 38.369627 0.0235251937 0.23975189 0.37383048 2 74555156 74555205 50 + 1.554 1.487 -0.228
ENSG00000115325 E019 50.397723 0.0126273671 0.13051466 0.23487580 2 74555206 74555282 77 + 1.674 1.600 -0.252
ENSG00000115325 E020 88.271134 0.0080132305 0.46322554 0.60305258 2 74555283 74555453 171 + 1.862 1.857 -0.019
ENSG00000115325 E021 2.273528 0.0157072014 0.30906475 0.45135308 2 74555454 74555574 121 + 0.586 0.426 -0.773
ENSG00000115325 E022 42.889370 0.0006935373 0.99007139 0.99787224 2 74555575 74555578 4 + 1.525 1.553 0.097
ENSG00000115325 E023 70.190584 0.0004243753 0.40463219 0.54833657 2 74555579 74555668 90 + 1.768 1.757 -0.037
ENSG00000115325 E024 89.622276 0.0003362741 0.85763055 0.91207857 2 74555894 74556078 185 + 1.849 1.870 0.073
ENSG00000115325 E025 431.791385 0.0128909139 0.04176456 0.09429915 2 74556308 74557551 1244 + 2.462 2.570 0.360