ENSG00000115317

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000258080 ENSG00000115317 HEK293_OSMI2_2hA HEK293_TMG_2hB HTRA2 protein_coding protein_coding 47.31108 72.64443 31.47297 2.89189 0.4920345 -1.206479 28.807753 48.78541 17.732893 2.505527 0.8777172 -1.459504 0.5695167 0.6710333 0.5629667 -0.108066667 0.01245254 2.819329e-05 FALSE TRUE
ENST00000696727 ENSG00000115317 HEK293_OSMI2_2hA HEK293_TMG_2hB HTRA2 protein_coding protein_coding 47.31108 72.64443 31.47297 2.89189 0.4920345 -1.206479 8.972938 14.67610 6.281467 1.328023 0.1203759 -1.222983 0.1937542 0.2014333 0.1997000 -0.001733333 1.00000000 2.819329e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115317 E001 6.704174 0.0026117845 2.292745e-01 3.615771e-01 2 74529596 74529724 129 + 0.677 0.853 0.709
ENSG00000115317 E002 6.850366 0.0104185156 6.086343e-01 7.283025e-01 2 74529725 74529778 54 + 0.765 0.842 0.302
ENSG00000115317 E003 10.864161 0.0017888781 8.565188e-01 9.112679e-01 2 74529779 74529821 43 + 0.981 1.004 0.086
ENSG00000115317 E004 25.430750 0.0176098316 6.234162e-01 7.400076e-01 2 74529822 74529912 91 + 1.381 1.338 -0.151
ENSG00000115317 E005 14.177162 0.0511283701 9.945922e-01 1.000000e+00 2 74529933 74529971 39 + 1.107 1.106 -0.004
ENSG00000115317 E006 15.730318 0.0061544965 1.597378e-01 2.747729e-01 2 74529972 74529989 18 + 1.246 1.111 -0.480
ENSG00000115317 E007 16.899083 0.0046136579 2.095283e-01 3.379809e-01 2 74529990 74530002 13 + 1.259 1.143 -0.410
ENSG00000115317 E008 16.344418 0.0044823871 2.157640e-01 3.453182e-01 2 74530003 74530006 4 + 1.246 1.130 -0.410
ENSG00000115317 E009 337.624207 0.0043647373 1.366577e-01 2.434220e-01 2 74530007 74530168 162 + 2.405 2.469 0.213
ENSG00000115317 E010 509.744505 0.0034180551 7.444517e-01 8.327845e-01 2 74530169 74530401 233 + 2.620 2.638 0.060
ENSG00000115317 E011 128.486755 0.0012290882 2.890217e-01 4.296951e-01 2 74530402 74530419 18 + 2.065 2.028 -0.125
ENSG00000115317 E012 128.476245 0.0010206505 3.436495e-01 4.877131e-01 2 74530420 74530425 6 + 2.061 2.029 -0.109
ENSG00000115317 E013 143.916810 0.0017877345 2.265882e-01 3.583357e-01 2 74530426 74530440 15 + 2.118 2.075 -0.143
ENSG00000115317 E014 139.623073 0.0014366414 3.154566e-01 4.582296e-01 2 74530441 74530444 4 + 2.098 2.063 -0.116
ENSG00000115317 E015 158.648273 0.0016296118 4.299578e-01 5.725950e-01 2 74530445 74530460 16 + 2.147 2.122 -0.084
ENSG00000115317 E016 208.680793 0.0002353813 6.832458e-01 7.865038e-01 2 74530461 74530512 52 + 2.234 2.249 0.049
ENSG00000115317 E017 3.103095 0.0054632085 9.273054e-01 9.582355e-01 2 74530597 74530610 14 + 0.566 0.553 -0.060
ENSG00000115317 E018 4.355219 0.0100756788 6.795925e-01 7.837366e-01 2 74530611 74530616 6 + 0.625 0.694 0.295
ENSG00000115317 E019 194.914722 0.0001905125 6.590462e-01 7.679704e-01 2 74530617 74530649 33 + 2.204 2.220 0.053
ENSG00000115317 E020 493.718880 0.0007748578 4.392882e-01 5.810363e-01 2 74530650 74530821 172 + 2.604 2.625 0.071
ENSG00000115317 E021 694.760392 0.0010584598 6.322244e-01 7.471105e-01 2 74530911 74531105 195 + 2.757 2.773 0.050
ENSG00000115317 E022 35.502978 0.0007252948 6.586308e-21 4.694343e-19 2 74531106 74531338 233 + 1.839 1.292 -1.873
ENSG00000115317 E023 372.450806 0.0002151373 7.489010e-01 8.360019e-01 2 74531339 74531371 33 + 2.501 2.498 -0.012
ENSG00000115317 E024 29.467467 0.0007090300 2.016473e-08 2.349848e-07 2 74531372 74531411 40 + 1.658 1.292 -1.259
ENSG00000115317 E025 28.034924 0.0058016949 1.858435e-12 4.358441e-11 2 74531412 74531505 94 + 1.724 1.210 -1.774
ENSG00000115317 E026 25.333996 0.0008092757 6.352119e-18 3.189478e-16 2 74531506 74531566 61 + 1.715 1.129 -2.031
ENSG00000115317 E027 17.200637 0.0010310314 1.855414e-12 4.351896e-11 2 74531567 74531596 30 + 1.548 0.978 -2.012
ENSG00000115317 E028 586.941666 0.0005758825 9.544071e-02 1.835462e-01 2 74531597 74531702 106 + 2.668 2.704 0.122
ENSG00000115317 E029 10.898436 0.0015245360 7.681674e-15 2.571603e-13 2 74531703 74531855 153 + 1.444 0.677 -2.834
ENSG00000115317 E030 519.652022 0.0003673774 7.950712e-03 2.365362e-02 2 74531856 74531925 70 + 2.600 2.655 0.185
ENSG00000115317 E031 23.739066 0.0011389595 1.092022e-08 1.336782e-07 2 74531926 74532566 641 + 1.597 1.188 -1.419
ENSG00000115317 E032 422.351103 0.0001419656 1.128679e-04 5.810617e-04 2 74532619 74532714 96 + 2.488 2.570 0.273
ENSG00000115317 E033 704.595480 0.0007845566 1.510884e-02 4.073324e-02 2 74532820 74533350 531 + 2.735 2.787 0.172