ENSG00000115310

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000317610 ENSG00000115310 HEK293_OSMI2_2hA HEK293_TMG_2hB RTN4 protein_coding protein_coding 72.05857 53.75397 87.17064 2.518444 1.212434 0.6973681 46.112004 34.963591 54.509523 0.996264 0.4651930 0.640507 0.6508500 0.6549333 0.62560000 -0.02933333 8.346311e-01 5.211331e-07 FALSE TRUE
ENST00000394609 ENSG00000115310 HEK293_OSMI2_2hA HEK293_TMG_2hB RTN4 protein_coding protein_coding 72.05857 53.75397 87.17064 2.518444 1.212434 0.6973681 5.280104 10.522105 1.611923 3.774156 0.2003511 -2.699016 0.0830500 0.1907000 0.01846667 -0.17223333 5.211331e-07 5.211331e-07 FALSE TRUE
MSTRG.18417.9 ENSG00000115310 HEK293_OSMI2_2hA HEK293_TMG_2hB RTN4 protein_coding   72.05857 53.75397 87.17064 2.518444 1.212434 0.6973681 16.249124 6.684866 24.678058 1.082586 1.4278738 1.882686 0.2068583 0.1250667 0.28276667 0.15770000 3.040003e-04 5.211331e-07   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000115310 E001 0.3697384 0.0274424043 1.388748e-01 2.465551e-01 2 54972187 54972188 2 - 0.000 0.241 11.696
ENSG00000115310 E002 777.9966674 0.0018195906 3.808356e-12 8.493830e-11 2 54972189 54972584 396 - 2.811 2.967 0.519
ENSG00000115310 E003 600.1184775 0.0001946614 1.345674e-39 4.528134e-37 2 54972585 54972795 211 - 2.673 2.874 0.668
ENSG00000115310 E004 136.4798989 0.0004804407 3.953543e-11 7.462259e-10 2 54972796 54972796 1 - 2.029 2.239 0.703
ENSG00000115310 E005 1129.5321975 0.0002579084 1.028805e-01 1.948674e-01 2 54972797 54973198 402 - 3.045 3.065 0.068
ENSG00000115310 E006 0.7415557 0.1149714850 3.086923e-01 4.509591e-01 2 54973513 54973562 50 - 0.331 0.136 -1.631
ENSG00000115310 E007 532.3771414 0.0001423249 1.930167e-03 7.009360e-03 2 54973563 54973621 59 - 2.749 2.702 -0.157
ENSG00000115310 E008 7.3293535 0.0026869151 1.994795e-02 5.137771e-02 2 54973622 54973820 199 - 1.041 0.765 -1.051
ENSG00000115310 E009 502.9976270 0.0002355007 4.201528e-02 9.475086e-02 2 54973821 54973867 47 - 2.717 2.685 -0.109
ENSG00000115310 E010 8.3559440 0.0040763327 2.704741e-03 9.387974e-03 2 54973868 54974191 324 - 1.113 0.765 -1.315
ENSG00000115310 E011 588.8688271 0.0001713309 1.154213e-03 4.485377e-03 2 54974695 54974764 70 - 2.794 2.746 -0.159
ENSG00000115310 E012 702.3952046 0.0001085146 6.274666e-07 5.443303e-06 2 54982515 54982653 139 - 2.879 2.814 -0.217
ENSG00000115310 E013 545.5219601 0.0006054051 7.451275e-08 7.757016e-07 2 54987491 54987698 208 - 2.783 2.687 -0.322
ENSG00000115310 E014 2.8066160 0.0055029607 1.653361e-02 4.391384e-02 2 55010087 55010449 363 - 0.723 0.325 -1.942
ENSG00000115310 E015 43.0947105 0.0058659144 3.992361e-13 1.042653e-11 2 55025086 55027206 2121 - 1.820 1.308 -1.751
ENSG00000115310 E016 6.1929011 0.0133100337 3.355470e-02 7.888070e-02 2 55027207 55027485 279 - 0.967 0.674 -1.152
ENSG00000115310 E017 7.4571205 0.0250355373 1.024705e-01 1.942719e-01 2 55028164 55028220 57 - 1.018 0.792 -0.858
ENSG00000115310 E018 0.0000000       2 55046816 55046886 71 -      
ENSG00000115310 E019 0.4407149 0.0214749159 7.280813e-01 8.206086e-01 2 55049079 55049198 120 - 0.196 0.137 -0.622
ENSG00000115310 E020 0.3289534 0.0301606989 8.489484e-01   2 55049297 55049354 58 - 0.109 0.137 0.380
ENSG00000115310 E021 1.4800029 0.0113526518 3.805783e-01 5.248509e-01 2 55049558 55049744 187 - 0.477 0.325 -0.846
ENSG00000115310 E022 691.2007740 0.0041269029 1.114163e-03 4.351342e-03 2 55049745 55050427 683 - 2.888 2.782 -0.353
ENSG00000115310 E023 172.2238949 0.0020824178 1.122259e-02 3.169999e-02 2 55050428 55050598 171 - 2.278 2.189 -0.298
ENSG00000115310 E024 0.0000000       2 55050717 55050828 112 -      
ENSG00000115310 E025 0.4502799 0.0297207107 1.347775e-01 2.407792e-01 2 55056483 55056557 75 - 0.269 0.000 -11.806
ENSG00000115310 E026 0.0000000       2 55060606 55060753 148 -      
ENSG00000115310 E027 0.2903454 0.3480859011 3.806347e-01   2 55080489 55080639 151 - 0.196 0.000 -11.216
ENSG00000115310 E028 0.0000000       2 55112520 55112621 102 -